Simulation scenario 6, CR phase

Setting description

TC5 more effective in the PI3K+ biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.087, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 11.2, median = 8.1
all	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.28, hr = 0.77
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.095, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.3, median = 7.4
AR- & TP53-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.17, hr = 0.85
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.097, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.1, median = 7.3
HRD+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.15, hr = 0.86
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.073, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.5, median = 9.7
TP53+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.53, hr = 0.64
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.074, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.3, median = 9.5
TEfus+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.51, hr = 0.65
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
PI3K+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
—-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
—+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
—++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
–+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
–++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
–+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
-+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
-+–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
-+-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
-++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
-++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
-+++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
-++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
+—+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
+–++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
+-+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
+-+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
++—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
++–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
++-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
+++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
+++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33
++++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
++++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 25, median = 18
+++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 2.85, hr = 0.33

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 6 4 5 2 62 AR- & TP53- 18 27 10 14 60 HRD+ 7 10 5 13 17 TP53+ 1 1 3 1 61 TEfus+ 3 0 3 1 34 PI3K+ 0 1 1 2 312

TC1 TC2 TC3 TC4 TC5 all 0.012 0.008 0.010 0.004 0.124 AR- & TP53- 0.036 0.054 0.020 0.028 0.120 HRD+ 0.014 0.020 0.010 0.026 0.034 TP53+ 0.002 0.002 0.006 0.002 0.122 TEfus+ 0.006 0.000 0.006 0.002 0.068 PI3K+ 0.000 0.002 0.002 0.004 0.624

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 10 4 2 0 0 AR- & TP53- 104 79 68 78 2 HRD+ 13 16 38 34 2 TP53+ 55 52 44 41 0 TEfus+ 29 26 18 22 0 PI3K+ 59 56 42 50 0

TC1 TC2 TC3 TC4 TC5 all 0.020 0.008 0.004 0.000 0.000 AR- & TP53- 0.208 0.158 0.136 0.156 0.004 HRD+ 0.026 0.032 0.076 0.068 0.004 TP53+ 0.110 0.104 0.088 0.082 0.000 TEfus+ 0.058 0.052 0.036 0.044 0.000 PI3K+ 0.118 0.112 0.084 0.100 0.000

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 64 41 43 49 36 HRD+ 0 0 0 0 0 TP53+ 0 0 0 0 0 TEfus+ 0 0 0 0 0 PI3K+ 0 0 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.000 0.000 AR- & TP53- 0.128 0.082 0.086 0.098 0.072 HRD+ 0.000 0.000 0.000 0.000 0.000 TP53+ 0.000 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.000 0.000 PI3K+ 0.000 0.000 0.000 0.000 0.000

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.368	0.066	0.086	0.05	0.064	0.156
err_type	0.562	0.066	0.086	0.05	0.064	0.396
pow_sign	0.624	0.000	0.000	0.00	0.000	0.624
pow_type	0.780	0.000	0.000	0.00	0.000	0.780

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	6	4	5	2	62
all	futility	0	10	4	2	0	0
all	max_n	0	0	0	0	0	0
all	n	377 (337, 414)	168 (98, 227)	161 (109, 228)	164 (106, 222)	160 (103, 222)	149 (42, 222)
all	n_unique	345 (310, 378)	156 (89, 211)	148 (98, 212)	150 (96, 206)	146 (95, 204)	135 (39, 205)
all	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (9, 36)
all	time_stop	NA (NA, NA)	5 (4, 14)	6 (5, 15)	7 (6, 21)	8 (6, 9)	7 (6, 10)
all	post_p	NA (NA, NA)	0.46 (0.07, 0.89)	0.47 (0.08, 0.9)	0.41 (0.08, 0.89)	0.44 (0.08, 0.85)	1 (1, 1)
all	rate	0.112 (0.104, 0.121)	0.113 (0.101, 0.129)	0.112 (0.101, 0.127)	0.114 (0.102, 0.128)	0.113 (0.101, 0.128)	0.068 (0.054, 0.081)
AR- & TP53-	graduation	0	18	27	10	14	60
AR- & TP53-	futility	0	104	79	68	78	2
AR- & TP53-	max_n	0	64	41	43	49	36
AR- & TP53-	n	222 (188, 258)	97 (30, 151)	82 (32, 145)	93 (39, 146)	82 (36, 148)	78 (23, 140)
AR- & TP53-	n_unique	205 (173, 237)	90 (29, 142)	75 (29, 135)	86 (36, 136)	75 (33, 137)	70 (21, 130)
AR- & TP53-	time_trial	36 (36, 36)	36 (10, 36)	36 (16, 36)	36 (23, 36)	36 (16, 36)	36 (21, 36)
AR- & TP53-	time_stop	NA (NA, NA)	12 (5, 25)	16 (9, 32)	18 (10, 31)	16 (10, 28)	12 (9, 26)
AR- & TP53-	post_p	NA (NA, NA)	0.46 (0.08, 0.88)	0.45 (0.08, 0.88)	0.42 (0.09, 0.85)	0.44 (0.07, 0.87)	0.99 (0.85, 1)
AR- & TP53-	rate	0.112 (0.102, 0.124)	0.113 (0.098, 0.141)	0.115 (0.097, 0.139)	0.115 (0.098, 0.137)	0.114 (0.096, 0.143)	0.076 (0.053, 0.096)
HRD+	graduation	0	7	10	5	13	17
HRD+	futility	0	13	16	38	34	2
HRD+	max_n	0	0	0	0	0	0
HRD+	n	59 (48, 72)	26 (11, 42)	27 (14, 40)	33 (20, 48)	31 (19, 49)	22 (4, 37)
HRD+	n_unique	53 (42, 65)	24 (10, 38)	24 (12, 37)	30 (18, 44)	29 (17, 45)	20 (4, 34)
HRD+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
HRD+	time_stop	NA (NA, NA)	29 (26, 35)	30 (23, 34)	30 (21, 35)	27 (19, 33)	25 (22, 34)
HRD+	post_p	NA (NA, NA)	0.48 (0.13, 0.85)	0.46 (0.13, 0.84)	0.44 (0.11, 0.84)	0.49 (0.1, 0.87)	0.73 (0.31, 0.97)
HRD+	rate	0.112 (0.092, 0.135)	0.112 (0.085, 0.159)	0.115 (0.089, 0.158)	0.115 (0.091, 0.153)	0.114 (0.087, 0.155)	0.092 (0.061, 0.133)
TP53+	graduation	0	1	1	3	1	61
TP53+	futility	0	55	52	44	41	0
TP53+	max_n	0	0	0	0	0	0
TP53+	n	127 (109, 144)	56 (32, 80)	62 (36, 86)	56 (36, 80)	57 (37, 79)	48 (18, 90)
TP53+	n_unique	115 (99, 132)	51 (30, 73)	56 (33, 79)	51 (32, 72)	52 (33, 72)	44 (17, 82)
TP53+	time_trial	36 (36, 36)	36 (31, 36)	36 (34, 36)	36 (36, 36)	36 (36, 36)	36 (22, 36)
TP53+	time_stop	NA (NA, NA)	22 (15, 31)	20 (13, 32)	23 (17, 33)	26 (17, 33)	16 (12, 25)
TP53+	post_p	NA (NA, NA)	0.41 (0.07, 0.84)	0.49 (0.09, 0.86)	0.42 (0.1, 0.84)	0.44 (0.1, 0.83)	1 (0.98, 1)
TP53+	rate	0.112 (0.098, 0.127)	0.115 (0.096, 0.143)	0.111 (0.094, 0.137)	0.114 (0.095, 0.14)	0.114 (0.095, 0.137)	0.057 (0.042, 0.072)
TEfus+	graduation	0	3	0	3	1	34
TEfus+	futility	0	29	26	18	22	0
TEfus+	max_n	0	0	0	0	0	0
TEfus+	n	118 (103, 135)	54 (32, 76)	61 (40, 82)	57 (37, 76)	57 (37, 77)	47 (18, 81)
TEfus+	n_unique	107 (93, 123)	49 (29, 68)	55 (36, 74)	51 (33, 70)	51 (33, 70)	43 (17, 76)
TEfus+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
TEfus+	time_stop	NA (NA, NA)	21 (15, 29)	24 (14, 30)	28 (18, 35)	25 (17, 34)	16 (12, 27)
TEfus+	post_p	NA (NA, NA)	0.47 (0.1, 0.85)	0.46 (0.11, 0.84)	0.44 (0.09, 0.84)	0.47 (0.1, 0.84)	1 (0.97, 1)
TEfus+	rate	0.113 (0.099, 0.128)	0.113 (0.095, 0.14)	0.112 (0.095, 0.141)	0.114 (0.096, 0.142)	0.113 (0.095, 0.138)	0.059 (0.044, 0.076)
PI3K+	graduation	0	0	1	1	2	312
PI3K+	futility	0	59	56	42	50	0
PI3K+	max_n	0	0	0	0	0	0
PI3K+	n	127 (109, 145)	51 (27, 76)	53 (29, 80)	55 (33, 81)	54 (30, 78)	49 (25, 110)
PI3K+	n_unique	116 (100, 133)	46 (25, 70)	48 (27, 73)	49 (29, 73)	49 (28, 72)	44 (22, 100)
PI3K+	time_trial	36 (36, 36)	36 (31, 36)	36 (33, 36)	36 (36, 36)	36 (35, 36)	25 (11, 36)
PI3K+	time_stop	NA (NA, NA)	22 (15, 32)	23 (15, 33)	25 (18, 33)	23 (16, 33)	17 (11, 28)
PI3K+	post_p	NA (NA, NA)	0.4 (0.07, 0.84)	0.43 (0.09, 0.84)	0.4 (0.08, 0.83)	0.41 (0.07, 0.84)	1 (1, 1)
PI3K+	rate	0.112 (0.098, 0.127)	0.114 (0.093, 0.146)	0.113 (0.093, 0.143)	0.114 (0.095, 0.138)	0.114 (0.092, 0.142)	0.039 (0.03, 0.048)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	23	31	15	16	118
—–	futility	0	111	82	69	78	2
—–	max_n	0	64	41	43	49	36
—–	n	126 (102, 152)	50 (18, 102)	39 (12, 94)	47 (11, 93)	37 (10, 93)	28 (6, 86)
—–	n_unique	117 (94, 142)	48 (18, 98)	36 (11, 89)	44 (10, 88)	36 (9, 89)	26 (6, 82)
—–	post_p	NA (NA, NA)	0.46 (0.1, 0.9)	0.41 (0.09, 0.88)	0.42 (0.08, 0.87)	0.4 (0.08, 0.85)	0.5 (0.09, 0.88)
—–	rate	0.113 (0.1, 0.128)	0.116 (0.097, 0.153)	0.119 (0.095, 0.178)	0.117 (0.094, 0.186)	0.121 (0.096, 0.186)	0.115 (0.088, 0.201)
—-+	graduation	0	23	30	16	16	363
—-+	futility	0	139	121	97	110	2
—-+	max_n	0	63	40	42	48	34
—-+	n	32 (23, 41)	9 (3, 23)	9 (3, 23)	10 (3, 26)	9 (3, 22)	12 (5, 31)
—-+	n_unique	30 (21, 38)	8 (3, 21)	8 (2, 21)	9 (3, 23)	8 (2, 20)	11 (4, 28)
—-+	post_p	NA (NA, NA)	0.41 (0.14, 0.8)	0.41 (0.16, 0.76)	0.39 (0.14, 0.75)	0.39 (0.16, 0.78)	0.99 (0.83, 1)
—-+	rate	0.114 (0.087, 0.151)	0.121 (0.081, 0.279)	0.123 (0.078, 0.301)	0.122 (0.084, 0.258)	0.123 (0.081, 0.274)	0.04 (0.024, 0.065)
—+-	graduation	0	24	31	17	15	141
—+-	futility	0	122	93	78	89	2
—+-	max_n	0	64	41	42	49	36
—+-	n	5 (2, 8)	3 (1, 6)	3 (1, 6)	2 (0, 6)	2 (0, 6)	2 (0, 5)
—+-	n_unique	4 (1, 8)	2 (1, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)
—+-	post_p	NA (NA, NA)	0.48 (0.28, 0.76)	0.47 (0.27, 0.72)	0.48 (0.31, 0.76)	0.45 (0.27, 0.72)	0.48 (0.28, 0.74)
—+-	rate	0.114 (0.059, 0.232)	0.128 (0.052, 0.381)	0.135 (0.054, 0.466)	0.122 (0.05, 0.404)	0.138 (0.055, 0.53)	0.123 (0.038, 0.428)
—++	graduation	0	24	30	18	16	363
—++	futility	0	143	129	104	118	2
—++	max_n	0	63	40	41	48	34
—++	n	14 (9, 20)	5 (1, 12)	5 (1, 12)	5 (2, 12)	5 (2, 12)	5 (2, 14)
—++	n_unique	13 (8, 19)	4 (1, 11)	4 (1, 10)	5 (1, 11)	5 (1, 11)	5 (2, 13)
—++	post_p	NA (NA, NA)	0.41 (0.19, 0.75)	0.41 (0.2, 0.74)	0.42 (0.2, 0.75)	0.42 (0.2, 0.75)	0.9 (0.56, 0.99)
—++	rate	0.115 (0.075, 0.173)	0.128 (0.068, 0.311)	0.129 (0.071, 0.317)	0.122 (0.064, 0.325)	0.128 (0.067, 0.357)	0.043 (0.02, 0.093)
–+–	graduation	0	7	5	8	3	119
–+–	futility	0	64	55	46	41	0
–+–	max_n	0	0	0	0	0	0
–+–	n	26 (19, 34)	11 (4, 24)	11 (4, 24)	10 (4, 22)	11 (4, 23)	8 (2, 19)
–+–	n_unique	24 (16, 32)	10 (3, 22)	10 (4, 23)	9 (3, 21)	10 (3, 21)	7 (2, 18)
–+–	post_p	NA (NA, NA)	0.43 (0.16, 0.84)	0.48 (0.18, 0.86)	0.4 (0.16, 0.85)	0.45 (0.17, 0.82)	0.47 (0.19, 0.83)
–+–	rate	0.111 (0.084, 0.151)	0.124 (0.085, 0.29)	0.116 (0.081, 0.24)	0.129 (0.082, 0.259)	0.123 (0.083, 0.257)	0.125 (0.077, 0.282)
–+-+	graduation	0	7	6	9	4	373
–+-+	futility	0	102	98	74	75	0
–+-+	max_n	0	0	0	0	0	0
–+-+	n	26 (20, 35)	7 (3, 21)	8 (3, 21)	9 (3, 22)	9 (3, 22)	10 (4, 27)
–+-+	n_unique	24 (18, 33)	7 (3, 19)	7 (3, 19)	8 (3, 20)	8 (3, 19)	9 (3, 25)
–+-+	post_p	NA (NA, NA)	0.37 (0.15, 0.72)	0.39 (0.14, 0.77)	0.4 (0.14, 0.78)	0.37 (0.16, 0.77)	0.98 (0.8, 1)
–+-+	rate	0.112 (0.086, 0.153)	0.131 (0.081, 0.261)	0.123 (0.077, 0.269)	0.122 (0.081, 0.286)	0.123 (0.077, 0.25)	0.038 (0.021, 0.069)
–++-	graduation	0	10	5	10	4	135
–++-	futility	0	79	71	55	55	0
–++-	max_n	0	0	0	0	0	0
–++-	n	7 (3, 11)	3 (1, 7)	4 (1, 9)	3 (1, 7)	3 (1, 7)	2 (0, 6)
–++-	n_unique	7 (3, 10)	3 (1, 7)	4 (1, 8)	3 (1, 6)	3 (1, 7)	2 (0, 6)
–++-	post_p	NA (NA, NA)	0.45 (0.25, 0.8)	0.48 (0.25, 0.81)	0.49 (0.27, 0.76)	0.47 (0.25, 0.78)	0.47 (0.28, 0.75)
–++-	rate	0.119 (0.068, 0.221)	0.136 (0.057, 0.514)	0.133 (0.062, 0.353)	0.13 (0.054, 0.359)	0.132 (0.059, 0.446)	0.134 (0.06, 0.467)
–+++	graduation	0	10	6	11	5	373
–+++	futility	0	110	108	82	88	0
–+++	max_n	0	0	0	0	0	0
–+++	n	20 (14, 27)	7 (3, 17)	8 (3, 18)	7 (3, 16)	7 (2, 16)	8 (3, 20)
–+++	n_unique	18 (13, 25)	6 (2, 15)	7 (2, 17)	7 (2, 15)	6 (2, 15)	7 (2, 18)
–+++	post_p	NA (NA, NA)	0.37 (0.15, 0.75)	0.41 (0.17, 0.74)	0.43 (0.18, 0.77)	0.4 (0.17, 0.8)	0.96 (0.64, 1)
–+++	rate	0.114 (0.081, 0.159)	0.128 (0.077, 0.317)	0.125 (0.077, 0.264)	0.124 (0.07, 0.278)	0.125 (0.069, 0.334)	0.04 (0.019, 0.082)
-+—	graduation	0	29	38	20	28	132
-+—	futility	0	121	95	95	106	4
-+—	max_n	0	64	39	41	49	36
-+—	n	26 (18, 35)	9 (1, 23)	9 (2, 20)	12 (4, 25)	10 (4, 25)	7 (1, 20)
-+—	n_unique	24 (16, 31)	8 (1, 21)	8 (2, 18)	11 (4, 23)	10 (4, 23)	6 (1, 18)
-+—	post_p	NA (NA, NA)	0.45 (0.17, 0.85)	0.44 (0.19, 0.8)	0.46 (0.15, 0.84)	0.46 (0.15, 0.84)	0.45 (0.16, 0.84)
-+—	rate	0.112 (0.083, 0.146)	0.12 (0.075, 0.268)	0.125 (0.081, 0.272)	0.118 (0.081, 0.257)	0.119 (0.081, 0.246)	0.123 (0.076, 0.309)
-+–+	graduation	0	29	37	21	28	363
-+–+	futility	0	149	132	121	135	4
-+–+	max_n	0	63	38	40	48	34
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	0.51 (0.47, 0.55)	0.55 (0.53, 0.58)	0.5 (0.5, 0.5)	0.59 (0.59, 0.59)	0.48 (0.48, 0.48)
-+–+	rate	0.121 (0, 0.636)	0.16 (0, 0.573)	0.104 (0, 3.802)	0.149 (0.082, 0.598)	0.084 (0, 0.292)	0.041 (0, 0.453)
-+-+-	graduation	0	30	38	22	26	155
-+-+-	futility	0	132	105	103	115	4
-+-+-	max_n	0	64	39	40	49	36
-+-+-	n	12 (7, 18)	4 (0, 10)	5 (1, 11)	6 (2, 13)	6 (2, 12)	4 (0, 10)
-+-+-	n_unique	11 (6, 17)	4 (0, 9)	4 (1, 10)	5 (2, 12)	5 (2, 11)	4 (0, 10)
-+-+-	post_p	NA (NA, NA)	0.45 (0.22, 0.79)	0.46 (0.21, 0.79)	0.45 (0.21, 0.8)	0.48 (0.22, 0.83)	0.49 (0.24, 0.8)
-+-+-	rate	0.114 (0.073, 0.176)	0.129 (0.068, 0.382)	0.131 (0.07, 0.377)	0.13 (0.073, 0.289)	0.12 (0.07, 0.275)	0.123 (0.06, 0.286)
-+-++	graduation	0	30	37	23	27	363
-+-++	futility	0	153	139	127	141	4
-+-++	max_n	0	63	38	39	48	34
-+-++	n	5 (2, 9)	2 (0, 5)	2 (0, 5)	3 (1, 6)	3 (1, 6)	1 (0, 4)
-+-++	n_unique	4 (2, 8)	2 (0, 5)	2 (0, 5)	3 (0, 5)	3 (1, 6)	1 (0, 4)
-+-++	post_p	NA (NA, NA)	0.46 (0.28, 0.72)	0.47 (0.29, 0.72)	0.42 (0.24, 0.68)	0.44 (0.26, 0.71)	0.7 (0.43, 0.91)
-+-++	rate	0.115 (0.059, 0.244)	0.135 (0.042, 0.431)	0.121 (0.042, 0.41)	0.147 (0.059, 0.484)	0.135 (0.059, 0.453)	0.04 (0, 0.16)
-++–	graduation	0	14	14	12	16	133
-++–	futility	0	76	70	77	72	2
-++–	max_n	0	0	0	0	0	0
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.54 (0.54, 0.54)	0.54 (0.54, 0.54)	0.53 (0.48, 0.57)	0.49 (0.48, 0.5)	NA (NA, NA)
-++–	rate	0.161 (0.006, 1.028)	0.146 (0, 1.258)	0.104 (0, 0.68)	0.091 (0, 0.996)	0.193 (0, 0.596)	0.128 (0, 2.062)
-++-+	graduation	0	14	15	13	17	374
-++-+	futility	0	113	111	103	101	2
-++-+	max_n	0	0	0	0	0	0
-++-+	n	2 (0, 5)	1 (0, 4)	1 (0, 3)	2 (0, 4)	2 (0, 4)	1 (0, 2)
-++-+	n_unique	2 (0, 5)	1 (0, 3)	1 (0, 3)	2 (0, 4)	1 (0, 4)	1 (0, 2)
-++-+	post_p	NA (NA, NA)	0.47 (0.33, 0.68)	0.48 (0.32, 0.68)	0.46 (0.32, 0.67)	0.45 (0.31, 0.65)	0.6 (0.41, 0.79)
-++-+	rate	0.118 (0.038, 0.359)	0.132 (0, 0.658)	0.133 (0, 0.589)	0.136 (0.047, 0.415)	0.146 (0.043, 0.604)	0.05 (0, 0.232)
-+++-	graduation	0	17	14	14	16	149
-+++-	futility	0	91	84	85	83	2
-+++-	max_n	0	0	0	0	0	0
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.46 (0.45, 0.52)	0.59 (0.59, 0.59)	0.48 (0.46, 0.5)	0.5 (0.47, 0.53)	0.5 (0.48, 0.52)
-+++-	rate	0.114 (0, 0.536)	0.179 (0, 1.396)	0.133 (0, 1.547)	0.373 (0.119, 2.476)	0.152 (0.057, 1.567)	0.488 (0.117, 1.902)
-++++	graduation	0	17	15	15	17	374
-++++	futility	0	121	120	110	111	2
-++++	max_n	0	0	0	0	0	0
-++++	n	3 (1, 6)	1 (0, 4)	1 (0, 4)	2 (0, 4)	2 (0, 4)	1 (0, 3)
-++++	n_unique	3 (0, 5)	1 (0, 3)	1 (0, 3)	2 (0, 4)	2 (0, 4)	0 (0, 3)
-++++	post_p	NA (NA, NA)	0.46 (0.3, 0.67)	0.47 (0.33, 0.68)	0.45 (0.31, 0.66)	0.46 (0.31, 0.66)	0.63 (0.39, 0.83)
-++++	rate	0.124 (0.047, 0.361)	0.138 (0.037, 0.48)	0.134 (0.027, 0.718)	0.136 (0.045, 0.454)	0.131 (0.038, 0.463)	0.043 (0, 0.225)
+—-	graduation	0	6	4	5	2	62
+—-	futility	0	10	4	2	0	0
+—-	max_n	0	0	0	0	0	0
+—-	n	5 (2, 8)	2 (1, 5)	3 (1, 6)	2 (1, 5)	2 (1, 5)	2 (0, 5)
+—-	n_unique	4 (1, 7)	2 (0, 5)	3 (1, 6)	2 (1, 5)	2 (0, 5)	2 (0, 4)
+—-	post_p	NA (NA, NA)	0.48 (0.28, 0.74)	0.46 (0.26, 0.74)	0.48 (0.31, 0.74)	0.48 (0.28, 0.74)	0.48 (0.29, 0.76)
+—-	rate	0.124 (0.058, 0.292)	0.131 (0.048, 0.467)	0.138 (0.06, 0.371)	0.138 (0.05, 0.463)	0.138 (0.04, 0.501)	0.135 (0.049, 0.397)
+—+	graduation	0	6	5	6	4	362
+—+	futility	0	67	60	43	50	0
+—+	max_n	0	0	0	0	0	0
+—+	n	2 (0, 4)	1 (0, 3)	1 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 2)
+—+	n_unique	2 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 2)
+—+	post_p	NA (NA, NA)	0.47 (0.35, 0.64)	0.47 (0.36, 0.67)	0.48 (0.35, 0.64)	0.48 (0.35, 0.64)	0.58 (0.43, 0.75)
+—+	rate	0.121 (0.021, 0.41)	0.147 (0, 0.737)	0.137 (0.029, 0.569)	0.124 (0, 0.492)	0.128 (0, 0.697)	0.051 (0, 0.189)
+–+-	graduation	0	9	4	8	3	92
+–+-	futility	0	37	28	19	22	0
+–+-	max_n	0	0	0	0	0	0
+–+-	n	8 (4, 11)	4 (1, 8)	4 (2, 9)	3 (1, 7)	3 (1, 7)	3 (0, 7)
+–+-	n_unique	7 (4, 11)	3 (1, 7)	4 (1, 8)	3 (1, 7)	3 (1, 6)	3 (0, 6)
+–+-	post_p	NA (NA, NA)	0.47 (0.24, 0.79)	0.47 (0.22, 0.79)	0.47 (0.25, 0.78)	0.44 (0.25, 0.76)	0.45 (0.26, 0.78)
+–+-	rate	0.113 (0.068, 0.212)	0.135 (0.057, 0.378)	0.129 (0.065, 0.365)	0.133 (0.05, 0.432)	0.14 (0.057, 0.437)	0.135 (0.057, 0.424)
+–++	graduation	0	9	5	9	5	362
+–++	futility	0	78	76	55	67	0
+–++	max_n	0	0	0	0	0	0
+–++	n	3 (1, 7)	2 (0, 4)	2 (1, 5)	2 (0, 4)	2 (0, 5)	1 (0, 4)
+–++	n_unique	3 (1, 6)	2 (0, 4)	2 (0, 5)	2 (0, 4)	2 (0, 4)	1 (0, 4)
+–++	post_p	NA (NA, NA)	0.46 (0.29, 0.67)	0.45 (0.29, 0.67)	0.46 (0.28, 0.68)	0.46 (0.32, 0.71)	0.66 (0.45, 0.87)
+–++	rate	0.125 (0.044, 0.34)	0.14 (0.038, 0.469)	0.126 (0.049, 0.457)	0.13 (0.029, 0.551)	0.126 (0.036, 0.437)	0.04 (0, 0.153)
+-+–	graduation	0	7	5	8	3	119
+-+–	futility	0	64	55	46	41	0
+-+–	max_n	0	0	0	0	0	0
+-+–	n	1 (0, 3)	1 (0, 2)	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	n_unique	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	0 (0, 2)
+-+–	post_p	NA (NA, NA)	0.47 (0.36, 0.63)	0.49 (0.36, 0.64)	0.48 (0.38, 0.66)	0.48 (0.37, 0.63)	0.48 (0.38, 0.66)
+-+–	rate	0.123 (0, 0.485)	0.139 (0, 0.634)	0.132 (0, 0.61)	0.129 (0, 0.701)	0.142 (0, 0.916)	0.135 (0, 0.608)
+-+-+	graduation	0	7	6	9	4	373
+-+-+	futility	0	102	98	74	75	0
+-+-+	max_n	0	0	0	0	0	0
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	NA (NA, NA)	0.47 (0.44, 0.51)	0.51 (0.46, 0.56)	NA (NA, NA)	NA (NA, NA)
+-+-+	rate	0.087 (0, 0.932)	0.225 (0.139, 1.565)	0.145 (0.008, 1.631)	0.162 (0, 0.586)	0.027 (0, 0.405)	0.057 (0, 0.336)
+-++-	graduation	0	10	5	10	4	135
+-++-	futility	0	79	71	55	55	0
+-++-	max_n	0	0	0	0	0	0
+-++-	n	21 (15, 28)	8 (3, 18)	11 (4, 22)	8 (3, 17)	9 (3, 19)	5 (1, 16)
+-++-	n_unique	19 (13, 26)	8 (3, 16)	10 (4, 20)	7 (2, 16)	8 (3, 18)	5 (1, 15)
+-++-	post_p	NA (NA, NA)	0.48 (0.2, 0.83)	0.47 (0.17, 0.87)	0.44 (0.18, 0.82)	0.45 (0.18, 0.82)	0.49 (0.2, 0.84)
+-++-	rate	0.115 (0.082, 0.158)	0.122 (0.077, 0.274)	0.118 (0.079, 0.227)	0.126 (0.077, 0.307)	0.123 (0.079, 0.306)	0.121 (0.069, 0.3)
+-+++	graduation	0	10	6	11	5	373
+-+++	futility	0	110	108	82	88	0
+-+++	max_n	0	0	0	0	0	0
+-+++	n	17 (11, 23)	6 (2, 15)	7 (3, 15)	7 (3, 14)	6 (2, 15)	6 (2, 16)
+-+++	n_unique	15 (10, 21)	5 (2, 13)	6 (2, 13)	6 (2, 13)	5 (2, 13)	5 (2, 14)
+-+++	post_p	NA (NA, NA)	0.43 (0.19, 0.76)	0.4 (0.19, 0.76)	0.4 (0.18, 0.77)	0.39 (0.18, 0.75)	0.94 (0.61, 1)
+-+++	rate	0.113 (0.078, 0.168)	0.12 (0.073, 0.334)	0.122 (0.074, 0.27)	0.126 (0.074, 0.29)	0.125 (0.077, 0.313)	0.04 (0.019, 0.085)
++—	graduation	0	13	14	10	15	79
++—	futility	0	23	20	40	34	2
++—	max_n	0	0	0	0	0	0
++—	n	8 (4, 13)	4 (1, 8)	4 (1, 8)	4 (2, 9)	4 (2, 8)	3 (0, 7)
++—	n_unique	7 (3, 12)	3 (1, 7)	4 (1, 7)	4 (2, 8)	4 (2, 8)	3 (0, 7)
++—	post_p	NA (NA, NA)	0.49 (0.27, 0.78)	0.47 (0.24, 0.78)	0.47 (0.23, 0.74)	0.48 (0.25, 0.8)	0.5 (0.29, 0.78)
++—	rate	0.118 (0.065, 0.221)	0.124 (0.054, 0.328)	0.128 (0.058, 0.374)	0.123 (0.066, 0.332)	0.124 (0.063, 0.332)	0.122 (0.056, 0.31)
++–+	graduation	0	13	15	11	17	364
++–+	futility	0	79	73	78	79	2
++–+	max_n	0	0	0	0	0	0
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	0.53 (0.53, 0.53)	0.45 (0.45, 0.45)	NA (NA, NA)	0.51 (0.48, 0.56)	NA (NA, NA)
++–+	rate	0.179 (0.042, 0.598)	0.187 (0, 0.691)	0.205 (0, 1.124)	0.091 (0, 0.613)	0.056 (0, 0.333)	0.104 (0.072, 0.148)
++-+-	graduation	0	16	14	13	15	109
++-+-	futility	0	50	42	54	52	2
++-+-	max_n	0	0	0	0	0	0
++-+-	n	1 (0, 2)	0 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	0 (0, 2)
++-+-	n_unique	1 (0, 2)	0 (0, 2)	0 (0, 2)	1 (0, 2)	0 (0, 2)	0 (0, 2)
++-+-	post_p	NA (NA, NA)	0.48 (0.36, 0.61)	0.51 (0.41, 0.65)	0.49 (0.39, 0.61)	0.48 (0.37, 0.61)	0.5 (0.4, 0.6)
++-+-	rate	0.128 (0, 0.567)	0.129 (0, 0.535)	0.119 (0, 0.62)	0.145 (0, 0.65)	0.154 (0, 0.732)	0.131 (0, 0.683)
++-++	graduation	0	16	15	14	17	364
++-++	futility	0	90	88	87	92	2
++-++	max_n	0	0	0	0	0	0
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	0.53 (0.48, 0.59)	0.47 (0.46, 0.5)	NA (NA, NA)	0.44 (0.44, 0.44)	0.47 (0.47, 0.47)
++-++	rate	0.11 (0, 0.834)	0.295 (0.134, 0.924)	0.22 (0.017, 1.26)	0.156 (0, 2.448)	0.129 (0, 0.745)	0.079 (0, 0.318)
+++–	graduation	0	14	14	12	16	133
+++–	futility	0	76	70	77	72	2
+++–	max_n	0	0	0	0	0	0
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.47 (0.42, 0.6)	0.52 (0.45, 0.61)	0.49 (0.42, 0.53)	0.5 (0.44, 0.58)	0.53 (0.45, 0.62)
+++–	rate	0.139 (0, 0.875)	0.123 (0, 0.633)	0.154 (0, 0.702)	0.115 (0, 1.088)	0.152 (0, 0.99)	0.156 (0, 0.669)
+++-+	graduation	0	14	15	13	17	374
+++-+	futility	0	113	111	103	101	2
+++-+	max_n	0	0	0	0	0	0
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	NA (NA, NA)	0.56 (0.54, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+++-+	rate	0.246 (0, 1.846)	0.37 (0, 1.335)	0.126 (0, 0.547)	0.106 (0, 0.514)	0.228 (0, 1.559)	0.075 (0, 0.172)
++++-	graduation	0	17	14	14	16	149
++++-	futility	0	91	84	85	83	2
++++-	max_n	0	0	0	0	0	0
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)	0.52 (0.49, 0.52)	0.49 (0.44, 0.54)	0.49 (0.49, 0.49)
++++-	rate	0.133 (0, 0.562)	0.126 (0.044, 1.145)	0.129 (0, 1.16)	0.131 (0, 0.332)	0.154 (0, 0.73)	0.061 (0, 0.772)
+++++	graduation	0	17	15	15	17	374
+++++	futility	0	121	120	110	111	2
+++++	max_n	0	0	0	0	0	0
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	0.52 (0.51, 0.54)	0.51 (0.51, 0.51)	0.5 (0.44, 0.52)	0.62 (0.56, 0.64)	NA (NA, NA)
+++++	rate	0.147 (0.067, 1.59)	0.133 (0, 0.354)	0.159 (0, 1.542)	0.096 (0.036, 0.405)	0.165 (0, 0.456)	0.039 (0, 0.082)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	6	4	5	2	62
all	time_stop	6 (4, 6)	6 (5, 7)	7 (6, 7)	8 (6, 9)	7 (6, 10)
all	n_trt	34 (28, 46)	32 (28, 40)	26 (25, 29)	38 (31, 46)	31 (26, 44)
all	n_control	60 (50, 68)	59 (54, 62)	62 (52, 80)	69 (64, 74)	64 (49, 98)
all	post_p	0.94 (0.89, 0.96)	0.94 (0.9, 0.96)	0.91 (0.86, 0.95)	0.91 (0.89, 0.93)	0.98 (0.95, 1)
all	order	1 (1, 1)	1 (1, 1)	1 (1, 2)	1.5 (1.1, 1.9)	1 (1, 1)
AR- & TP53-	count	18	27	10	14	60
AR- & TP53-	time_stop	7 (5, 12)	10 (8, 13)	10 (9, 13)	11 (9, 15)	12 (9, 25)
AR- & TP53-	n_trt	35 (27, 47)	28 (25, 45)	28 (25, 49)	30 (25, 42)	30 (26, 65)
AR- & TP53-	n_control	43 (33, 61)	51 (38, 70)	51 (45, 82)	58 (49, 80)	64 (46, 139)
AR- & TP53-	post_p	0.9 (0.87, 0.97)	0.93 (0.86, 0.97)	0.92 (0.9, 0.98)	0.95 (0.89, 0.99)	0.99 (0.93, 1)
AR- & TP53-	order	1 (1, 2)	1 (1, 2)	1 (1, 1.1)	1 (1, 1.7)	1 (1, 2.1)
HRD+	count	7	10	5	13	17
HRD+	time_stop	29 (25, 29)	28 (22, 33)	22 (19, 29)	23 (17, 29)	25 (22, 32)
HRD+	n_trt	27 (26, 43)	26 (25, 34)	29 (26, 43)	28 (25, 38)	26 (25, 30)
HRD+	n_control	41 (33, 49)	48 (33, 57)	25 (22, 38)	30 (20, 46)	41 (28, 63)
HRD+	post_p	0.91 (0.89, 0.96)	0.91 (0.86, 0.96)	0.9 (0.85, 0.96)	0.94 (0.87, 0.99)	0.94 (0.91, 0.99)
HRD+	order	3 (2, 3)	3 (1, 4)	1 (1, 2)	2 (1.2, 2)	2 (1, 3)
TP53+	count	1	1	3	1	61
TP53+	time_stop	19 (19, 19)	9 (9, 9)	18 (16, 20)	10 (10, 10)	16 (12, 25)
TP53+	n_trt	42 (42, 42)	31 (31, 31)	26 (25, 27)	25 (25, 25)	31 (25, 45)
TP53+	n_control	65 (65, 65)	23 (23, 23)	55 (53, 56)	27 (27, 27)	48 (33, 82)
TP53+	post_p	0.97 (0.97, 0.97)	0.97 (0.97, 0.97)	0.94 (0.88, 0.95)	0.94 (0.94, 0.94)	1 (0.97, 1)
TP53+	order	2 (2, 2)	1 (1, 1)	3 (2.2, 3)	1 (1, 1)	1 (1, 2)
TEfus+	count	3		3	1	34
TEfus+	time_stop	15 (12, 17)		19 (17, 21)	15 (15, 15)	16 (12, 27)
TEfus+	n_trt	26 (25, 27)		26 (25, 28)	25 (25, 25)	27 (25, 39)
TEfus+	n_control	39 (29, 48)		42 (40, 60)	33 (33, 33)	46 (32, 87)
TEfus+	post_p	0.9 (0.89, 0.92)		0.98 (0.94, 0.99)	0.93 (0.93, 0.93)	0.99 (0.97, 1)
TEfus+	order	2 (2, 2)		1 (1, 1.8)	1 (1, 1)	2 (1, 3)
PI3K+	count		1	1	2	312
PI3K+	time_stop		17 (17, 17)	16 (16, 16)	17 (14, 20)	17 (11, 28)
PI3K+	n_trt		26 (26, 26)	31 (31, 31)	30 (27, 33)	40 (26, 77)
PI3K+	n_control		53 (53, 53)	50 (50, 50)	52 (46, 58)	51 (27, 90)
PI3K+	post_p		0.89 (0.89, 0.89)	0.97 (0.97, 0.97)	0.93 (0.9, 0.96)	1 (0.99, 1)
PI3K+	order		2 (2, 2)	2 (2, 2)	2.5 (2.1, 2.9)	1 (1, 2)

Futility:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	10	4	2
all	time_stop	4 (4, 22)	12 (7, 17)	23 (13, 33)
all	n_trt	32 (25, 81)	46 (34, 75)	57 (35, 79)
all	n_control	48 (38, 203)	110 (67, 153)	230 (125, 334)
all	post_p	0.13 (0.01, 0.23)	0.04 (0.02, 0.21)	0.03 (0.01, 0.06)
all	order	1 (1, 4)	1 (1, 2.4)	3 (2.2, 3.8)
AR- & TP53-	count	104	79	68	78	2
AR- & TP53-	time_stop	13 (5, 25)	20 (12, 33)	22 (12, 31)	16 (11, 29)	26 (18, 33)
AR- & TP53-	n_trt	38 (25, 79)	39 (25, 97)	40 (25, 88)	38 (26, 76)	44 (30, 58)
AR- & TP53-	n_control	72 (30, 154)	122 (64, 202)	117 (54, 203)	85 (55, 168)	135 (97, 173)
AR- & TP53-	post_p	0.12 (0.02, 0.27)	0.11 (0.02, 0.22)	0.08 (0.02, 0.21)	0.1 (0.03, 0.2)	0.16 (0.14, 0.18)
AR- & TP53-	order	1 (1, 2)	2 (1, 4)	1 (1, 3)	1 (1, 3)	3 (3, 3)
HRD+	count	13	16	38	34	2
HRD+	time_stop	29 (27, 36)	32 (26, 34)	30 (22, 35)	28 (21, 34)	32 (28, 35)
HRD+	n_trt	28 (25, 31)	27 (25, 36)	28 (25, 37)	28 (25, 34)	26 (25, 26)
HRD+	n_control	49 (41, 71)	52 (33, 66)	44 (30, 59)	44 (30, 59)	42 (32, 52)
HRD+	post_p	0.1 (0.01, 0.23)	0.16 (0.07, 0.26)	0.13 (0.07, 0.23)	0.09 (0.01, 0.24)	0.12 (0.08, 0.15)
HRD+	order	2 (1, 2.8)	2.5 (1, 5)	2 (1, 4)	2 (1, 4)	3 (2.2, 3.8)
TP53+	count	55	52	44	41
TP53+	time_stop	22 (15, 31)	20 (13, 32)	24 (17, 34)	27 (18, 33)
TP53+	n_trt	32 (26, 48)	32 (25, 51)	35 (25, 48)	35 (26, 51)
TP53+	n_control	68 (41, 104)	64 (37, 105)	76 (50, 110)	97 (53, 115)
TP53+	post_p	0.07 (0.02, 0.22)	0.08 (0.02, 0.19)	0.07 (0.02, 0.2)	0.11 (0.02, 0.2)
TP53+	order	2 (1, 4)	1 (1, 4)	2 (1, 4.7)	2 (1, 4)
TEfus+	count	29	26	18	22
TEfus+	time_stop	22 (16, 29)	24 (14, 30)	30 (18, 35)	26 (18, 34)
TEfus+	n_trt	31 (25, 42)	33 (26, 46)	34 (26, 49)	34 (27, 48)
TEfus+	n_control	66 (42, 98)	68 (31, 96)	94 (42, 130)	75 (43, 113)
TEfus+	post_p	0.04 (0.01, 0.1)	0.06 (0.02, 0.21)	0.05 (0.01, 0.22)	0.1 (0.01, 0.18)
TEfus+	order	3 (2, 4.2)	2 (1, 3)	3 (1, 5.3)	2 (1, 3)
PI3K+	count	59	56	42	50
PI3K+	time_stop	22 (15, 32)	23 (15, 33)	25 (18, 33)	24 (16, 33)
PI3K+	n_trt	28 (25, 50)	32 (26, 49)	32 (26, 53)	30 (25, 47)
PI3K+	n_control	68 (41, 109)	72 (42, 118)	79 (51, 112)	72 (48, 119)
PI3K+	post_p	0.07 (0.01, 0.24)	0.1 (0.03, 0.2)	0.06 (0.01, 0.22)	0.11 (0.01, 0.25)
PI3K+	order	2 (1, 4.2)	2 (1, 4)	2 (1, 4)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
all	TC1	time	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)	6 (4, 6)
all	TC1	n	16 (14, 28)	4 (2, 6)	0 (0, 1)	1 (0, 3)	2 (0, 4)	2 (0, 4)	0 (0, 2)	1 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 3)	1 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.62 (0.55, 0.86)	0.51 (0.5, 0.65)	0.51 (0.51, 0.51)	0.54 (0.51, 0.56)	0.56 (0.55, 0.58)	0.52 (0.51, 0.75)	0.55 (0.52, 0.58)	0.54 (0.52, 0.57)	0.55 (0.52, 0.58)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.53, 0.57)	0.52 (0.51, 0.53)	NA (NA, NA)	0.57 (0.51, 0.62)	0.57 (0.57, 0.57)	NA (NA, NA)	NA (NA, NA)	0.56 (0.51, 0.64)	0.56 (0.51, 0.58)	0.55 (0.55, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.074 (0.028, 0.09)	0.033 (0, 0.104)	0 (0, 0)	0 (0, 0.104)	0 (0, 0.04)	0 (0, 0)	0 (0, 0)	0 (0, 0.073)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0.098)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0.107)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC2	time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
all	TC2	n	12 (9, 16)	0 (0, 2)	0 (0, 1)	0 (0, 1)	2 (2, 4)	1 (1, 2)	1 (1, 2)	3 (1, 4)	0 (0, 3)	0 (0, 0)	1 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	2 (0, 2)	0 (0, 1)	1 (0, 3)	0 (0, 1)	0 (0, 1)	0 (0, 0)	4 (2, 5)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.76 (0.6, 0.85)	0.53 (0.52, 0.53)	0.55 (0.53, 0.57)	0.51 (0.51, 0.51)	0.56 (0.52, 0.58)	0.55 (0.54, 0.56)	0.53 (0.51, 0.59)	0.54 (0.53, 0.57)	0.51 (0.51, 0.52)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.52 (0.51, 0.53)	NA (NA, NA)	0.62 (0.62, 0.63)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.51, 0.53)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.072 (0.04, 0.079)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.067 (0.013, 0.121)	0.048 (0.01, 0.087)	NA (NA, NA)	0 (0, 1.416)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0.075)	0 (0, 0)	0.067 (0.013, 0.121)	0.142 (0.028, 0.255)	0 (0, 0)	NA (NA, NA)	0 (0, 0.036)	0.205 (0.205, 0.205)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC3	time	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)	7 (6, 7)
all	TC3	n	6 (2, 14)	1 (0, 2)	0 (0, 1)	1 (0, 2)	2 (1, 4)	1 (1, 2)	0 (0, 0)	1 (0, 1)	2 (2, 6)	0 (0, 0)	2 (0, 3)	0 (0, 1)	0 (0, 0)	1 (0, 1)	0 (0, 0)	0 (0, 2)	1 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	2 (0, 4)	1 (0, 3)	1 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.57 (0.52, 0.78)	0.53 (0.53, 0.53)	NA (NA, NA)	0.53 (0.51, 0.54)	0.54 (0.52, 0.58)	0.52 (0.52, 0.6)	NA (NA, NA)	0.53 (0.52, 0.54)	0.58 (0.53, 0.65)	NA (NA, NA)	0.54 (0.51, 0.56)	0.53 (0.53, 0.53)	NA (NA, NA)	0.54 (0.51, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.52, 0.65)	0.53 (0.52, 0.68)	0.53 (0.53, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0 (0, 0.102)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.083)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0.103)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.295 (0.059, 0.532)	0.394 (0.079, 0.829)	0 (0, 0)	NA (NA, NA)	1.097 (1.097, 1.097)	0 (0, 0)	NA (NA, NA)	0 (0, 0.055)	0 (0, 0)	0 (0, 0.046)	NA (NA, NA)	NA (NA, NA)	0.24 (0.24, 0.24)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC4	time	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)	8 (6, 9)
all	TC4	n	12 (6, 19)	2 (1, 3)	0 (0, 0)	0 (0, 0)	4 (3, 5)	2 (2, 2)	0 (0, 1)	0 (0, 0)	6 (5, 7)	0 (0, 0)	3 (2, 4)	1 (0, 2)	0 (0, 0)	2 (0, 3)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 3)	1 (1, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.68 (0.59, 0.76)	0.58 (0.54, 0.63)	NA (NA, NA)	NA (NA, NA)	0.53 (0.52, 0.54)	0.55 (0.55, 0.55)	0.56 (0.56, 0.56)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)	0.58 (0.58, 0.58)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.58 (0.57, 0.58)	0.55 (0.54, 0.55)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.119 (0.075, 0.163)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.062 (0.012, 0.112)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0.078 (0.016, 0.14)	NA (NA, NA)	0.045 (0.009, 0.08)	0.387 (0.387, 0.387)	NA (NA, NA)	0.131 (0.131, 0.131)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62	62
all	TC5	time	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)	7 (6, 10)
all	TC5	n	6 (2, 13)	6 (3, 8)	0 (0, 1)	3 (1, 6)	1 (0, 5)	4 (1, 7)	0 (0, 1)	3 (1, 6)	1 (0, 3)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 2)	0 (0, 1)	1 (0, 2)	0 (0, 1)	0 (0, 0)	1 (0, 2)	3 (1, 5)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.6 (0.53, 0.76)	0.62 (0.53, 0.73)	0.54 (0.54, 0.63)	0.57 (0.51, 0.72)	0.55 (0.52, 0.68)	0.6 (0.53, 0.78)	0.55 (0.52, 0.58)	0.56 (0.51, 0.69)	0.55 (0.52, 0.65)	NA (NA, NA)	0.54 (0.51, 0.63)	0.52 (0.51, 0.62)	NA (NA, NA)	0.52 (0.51, 0.58)	NA (NA, NA)	0.55 (0.51, 0.63)	0.57 (0.53, 0.76)	0.53 (0.51, 0.55)	0.57 (0.52, 0.65)	0.54 (0.51, 0.59)	0.54 (0.52, 0.56)	NA (NA, NA)	0.55 (0.52, 0.61)	0.56 (0.52, 0.69)	0.56 (0.51, 0.6)	NA (NA, NA)	0.55 (0.51, 0.58)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.055 (0, 0.102)	0 (0, 0.079)	0 (0, 1.059)	0 (0, 0.096)	0 (0, 0.096)	0 (0, 0.089)	0 (0, 0.096)	0 (0, 0.075)	0 (0, 0.083)	NA (NA, NA)	0 (0, 0.099)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0.052)	0 (0, 0.019)	0 (0, 0.206)	0 (0, 0)	0 (0, 0.811)	0 (0, 0)	0 (0, 0)	0 (0, 0.074)	0 (0, 0.12)	NA (NA, NA)	0 (0, 0.213)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	18	18	18	18					18	18	18	18
AR- & TP53-	TC1	time	7 (5, 12)	7 (5, 12)	7 (5, 12)	7 (5, 12)					7 (5, 12)	7 (5, 12)	7 (5, 12)	7 (5, 12)
AR- & TP53-	TC1	n	26 (21, 31)	4 (1, 6)	1 (0, 3)	1 (0, 3)					0 (0, 3)	0 (0, 0)	1 (0, 2)	0 (0, 2)
AR- & TP53-	TC1	post_p	0.86 (0.74, 0.94)	0.57 (0.52, 0.73)	0.55 (0.53, 0.57)	0.53 (0.5, 0.61)					0.56 (0.53, 0.63)	NA (NA, NA)	0.56 (0.52, 0.71)	0.58 (0.53, 0.65)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.075 (0.032, 0.089)	0.011 (0, 0.091)	0 (0, 0.178)	0 (0, 0.194)					0 (0, 0.104)	NA (NA, NA)	0 (0, 0.171)	0.055 (0, 0.291)
AR- & TP53-	TC2	count	27	27	27	27					27	27	27	27
AR- & TP53-	TC2	time	10 (8, 13)	10 (8, 13)	10 (8, 13)	10 (8, 13)					10 (8, 13)	10 (8, 13)	10 (8, 13)	10 (8, 13)
AR- & TP53-	TC2	n	21 (17, 33)	3 (1, 6)	1 (0, 2)	1 (0, 3)					3 (1, 5)	0 (0, 0)	0 (0, 2)	1 (0, 2)
AR- & TP53-	TC2	post_p	0.84 (0.73, 0.94)	0.58 (0.52, 0.75)	0.53 (0.51, 0.57)	0.55 (0.51, 0.63)					0.58 (0.53, 0.71)	0.55 (0.55, 0.55)	0.58 (0.53, 0.67)	0.57 (0.53, 0.65)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.066 (0.046, 0.099)	0 (0, 0.068)	0.056 (0, 0.232)	0 (0, 0.06)					0 (0, 0.088)	0 (0, 0)	0 (0, 0.067)	0 (0, 0.061)
AR- & TP53-	TC3	count	10	10	10	10					10	10	10	10
AR- & TP53-	TC3	time	10 (9, 13)	10 (9, 13)	10 (9, 13)	10 (9, 13)					10 (9, 13)	10 (9, 13)	10 (9, 13)	10 (9, 13)
AR- & TP53-	TC3	n	14 (11, 31)	4 (2, 5)	0 (0, 1)	1 (0, 3)					5 (4, 9)	0 (0, 0)	2 (1, 4)	1 (0, 3)
AR- & TP53-	TC3	post_p	0.81 (0.79, 0.87)	0.56 (0.51, 0.62)	0.55 (0.55, 0.55)	0.55 (0.52, 0.6)					0.76 (0.52, 0.91)	NA (NA, NA)	0.56 (0.52, 0.67)	NA (NA, NA)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.036 (0.019, 0.074)	0.026 (0, 0.128)	0 (0, 0.243)	0 (0, 0)					0.046 (0, 0.078)	NA (NA, NA)	0.029 (0, 0.1)	0.149 (0.016, 0.431)
AR- & TP53-	TC4	count	14	14	14	14					14	14	14	14
AR- & TP53-	TC4	time	11 (9, 15)	11 (9, 15)	11 (9, 15)	11 (9, 15)					11 (9, 15)	11 (9, 15)	11 (9, 15)	11 (9, 15)
AR- & TP53-	TC4	n	18 (13, 25)	3 (0, 6)	0 (0, 1)	1 (0, 3)					5 (3, 8)	0 (0, 0)	4 (0, 6)	1 (0, 3)
AR- & TP53-	TC4	post_p	0.84 (0.75, 0.94)	0.56 (0.52, 0.81)	0.56 (0.55, 0.59)	0.55 (0.52, 0.78)					0.62 (0.52, 0.81)	NA (NA, NA)	0.64 (0.52, 0.83)	0.61 (0.55, 0.74)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.055 (0.03, 0.098)	0 (0, 0.126)	0 (0, 0)	0 (0, 0.016)					0.043 (0, 0.096)	0.664 (0.664, 0.664)	0.044 (0, 0.18)	0.017 (0, 0.191)
AR- & TP53-	TC5	count	60	60	60	60					60	60	60	60
AR- & TP53-	TC5	time	12 (9, 25)	12 (9, 25)	12 (9, 25)	12 (9, 25)					12 (9, 25)	12 (9, 25)	12 (9, 25)	12 (9, 25)
AR- & TP53-	TC5	n	16 (9, 38)	8 (4, 12)	0 (0, 2)	4 (2, 8)					3 (1, 8)	0 (0, 0)	2 (0, 4)	0 (0, 2)
AR- & TP53-	TC5	post_p	0.78 (0.71, 0.88)	0.79 (0.64, 0.95)	0.59 (0.53, 0.68)	0.65 (0.52, 0.92)					0.59 (0.52, 0.76)	NA (NA, NA)	0.59 (0.52, 0.76)	0.55 (0.52, 0.73)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.073 (0.021, 0.101)	0.028 (0, 0.057)	0 (0, 0.175)	0.035 (0, 0.064)					0.062 (0, 0.103)	NA (NA, NA)	0 (0, 0.148)	0 (0, 0.082)
HRD+	TC1	count									7	7	7	7	7	7	7	7									7	7	7	7	7	7	7	7
HRD+	TC1	time									29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)									29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)	29 (25, 29)
HRD+	TC1	n									15 (5, 18)	0 (0, 0)	7 (5, 12)	2 (1, 4)	0 (0, 0)	2 (1, 3)	0 (0, 1)	2 (1, 4)									5 (3, 8)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.76 (0.64, 0.79)	NA (NA, NA)	0.74 (0.68, 0.84)	0.58 (0.53, 0.72)	NA (NA, NA)	0.61 (0.57, 0.66)	NA (NA, NA)	0.58 (0.54, 0.71)									0.71 (0.59, 0.82)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.075 (0.064, 0.097)	NA (NA, NA)	0.066 (0.048, 0.08)	0.07 (0.017, 0.12)	NA (NA, NA)	0.065 (0.026, 0.244)	0 (0, 0)	0.054 (0, 0.076)									0.078 (0.043, 0.099)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.66 (0.66, 0.66)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									10	10	10	10	10	10	10	10									10	10	10	10	10	10	10	10
HRD+	TC2	time									28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)									28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)	28 (22, 33)
HRD+	TC2	n									14 (9, 20)	0 (0, 0)	5 (2, 10)	1 (0, 4)	0 (0, 0)	1 (0, 2)	0 (0, 0)	2 (0, 3)									4 (2, 5)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.82 (0.75, 0.88)	NA (NA, NA)	0.82 (0.53, 0.87)	0.61 (0.55, 0.65)	NA (NA, NA)	0.58 (0.54, 0.73)	NA (NA, NA)	0.58 (0.53, 0.66)									0.62 (0.5, 0.82)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.079 (0.063, 0.098)	NA (NA, NA)	0.069 (0.044, 0.116)	0.036 (0, 0.103)	NA (NA, NA)	0.035 (0, 0.087)	NA (NA, NA)	0.109 (0, 0.149)									0.081 (0.036, 0.117)	NA (NA, NA)	0.075 (0.015, 0.135)	NA (NA, NA)	0.225 (0.225, 0.225)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									5	5	5	5	5	5	5	5									5	5	5	5	5	5	5	5
HRD+	TC3	time									22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)									22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)	22 (19, 29)
HRD+	TC3	n									19 (13, 20)	0 (0, 0)	4 (2, 6)	3 (0, 5)	0 (0, 0)	0 (0, 4)	0 (0, 0)	1 (1, 2)									4 (3, 9)	0 (0, 0)	1 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
HRD+	TC3	post_p									0.86 (0.82, 0.88)	NA (NA, NA)	0.64 (0.53, 0.8)	0.62 (0.53, 0.71)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	0.56 (0.52, 0.57)									0.56 (0.51, 0.75)	NA (NA, NA)	0.54 (0.51, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.062 (0.058, 0.098)	NA (NA, NA)	0.08 (0.064, 0.101)	0.164 (0.091, 0.428)	NA (NA, NA)	0.122 (0.076, 0.168)	NA (NA, NA)	0 (0, 0.233)									0.077 (0.059, 0.109)	NA (NA, NA)	0 (0, 0.418)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.234 (0.234, 0.234)
HRD+	TC4	count									13	13	13	13	13	13	13	13									13	13	13	13	13	13	13	13
HRD+	TC4	time									23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)									23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)	23 (17, 29)
HRD+	TC4	n									13 (8, 19)	0 (0, 0)	5 (3, 12)	3 (2, 4)	0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (1, 3)									3 (1, 5)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.84 (0.72, 0.92)	NA (NA, NA)	0.74 (0.63, 0.86)	0.57 (0.51, 0.77)	NA (NA, NA)	0.56 (0.52, 0.68)	NA (NA, NA)	0.53 (0.51, 0.69)									0.63 (0.55, 0.79)	NA (NA, NA)	0.57 (0.54, 0.6)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.077 (0.057, 0.098)	NA (NA, NA)	0.073 (0.023, 0.121)	0.073 (0, 0.122)	NA (NA, NA)	0.023 (0, 0.128)	NA (NA, NA)	0.09 (0, 0.578)									0.083 (0.023, 0.153)	NA (NA, NA)	0.112 (0, 0.422)	NA (NA, NA)	0.745 (0.745, 0.745)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	count									17	17	17	17	17	17	17	17									17	17	17	17	17	17	17	17
HRD+	TC5	time									25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)									25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)	25 (22, 32)
HRD+	TC5	n									14 (11, 18)	0 (0, 0)	6 (3, 10)	1 (0, 3)	0 (0, 0)	0 (0, 1)	0 (0, 0)	1 (0, 2)									3 (2, 5)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.8 (0.74, 0.92)	NA (NA, NA)	0.73 (0.6, 0.86)	0.66 (0.54, 0.77)	NA (NA, NA)	0.58 (0.53, 0.68)	NA (NA, NA)	0.61 (0.54, 0.74)									0.55 (0.51, 0.74)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.083 (0.057, 0.102)	NA (NA, NA)	0.074 (0.017, 0.112)	0 (0, 0.147)	NA (NA, NA)	0.02 (0, 0.093)	3.623 (3.623, 3.623)	0 (0, 0)									0.099 (0, 0.164)	NA (NA, NA)	0.173 (0.088, 0.209)	NA (NA, NA)	0.054 (0.015, 0.086)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					1	1	1	1					1	1	1	1					1	1	1	1					1	1	1	1
TP53+	TC1	time					19 (19, 19)	19 (19, 19)	19 (19, 19)	19 (19, 19)					19 (19, 19)	19 (19, 19)	19 (19, 19)	19 (19, 19)					19 (19, 19)	19 (19, 19)	19 (19, 19)	19 (19, 19)					19 (19, 19)	19 (19, 19)	19 (19, 19)	19 (19, 19)
TP53+	TC1	n					11 (11, 11)	14 (14, 14)	5 (5, 5)	5 (5, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	7 (7, 7)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.7 (0.7, 0.7)	0.76 (0.76, 0.76)	0.69 (0.69, 0.69)	0.8 (0.8, 0.8)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.72 (0.72, 0.72)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.086 (0.086, 0.086)	0.089 (0.089, 0.089)	0.114 (0.114, 0.114)	0 (0, 0)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.088 (0.088, 0.088)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					1	1	1	1					1	1	1	1					1	1	1	1					1	1	1	1
TP53+	TC2	time					9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)					9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)					9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)					9 (9, 9)	9 (9, 9)	9 (9, 9)	9 (9, 9)
TP53+	TC2	n					2 (2, 2)	4 (4, 4)	2 (2, 2)	1 (1, 1)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					1 (1, 1)	1 (1, 1)	17 (17, 17)	3 (3, 3)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.52 (0.52, 0.52)	0.63 (0.63, 0.63)	0.66 (0.66, 0.66)	0.56 (0.56, 0.56)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.93 (0.93, 0.93)	0.66 (0.66, 0.66)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.132 (0.132, 0.132)	0 (0, 0)	0 (0, 0)	0 (0, 0)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					0 (0, 0)	0.116 (0.116, 0.116)	0.021 (0.021, 0.021)	0 (0, 0)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					3	3	3	3					3	3	3	3					3	3	3	3					3	3	3	3
TP53+	TC3	time					18 (16, 20)	18 (16, 20)	18 (16, 20)	18 (16, 20)					18 (16, 20)	18 (16, 20)	18 (16, 20)	18 (16, 20)					18 (16, 20)	18 (16, 20)	18 (16, 20)	18 (16, 20)					18 (16, 20)	18 (16, 20)	18 (16, 20)	18 (16, 20)
TP53+	TC3	n					5 (4, 6)	5 (4, 7)	1 (1, 4)	6 (4, 8)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)					0 (0, 1)	0 (0, 0)	1 (0, 4)	3 (2, 5)					0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)
TP53+	TC3	post_p					0.68 (0.55, 0.88)	0.59 (0.54, 0.74)	0.56 (0.54, 0.73)	0.76 (0.63, 0.77)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.62 (0.62, 0.62)					NA (NA, NA)	NA (NA, NA)	0.57 (0.53, 0.61)	0.61 (0.56, 0.65)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.104 (0.06, 0.108)	0.053 (0.045, 0.071)	0 (0, 0.035)	0.07 (0.04, 0.114)					NA (NA, NA)	0.79 (0.208, 1.373)	NA (NA, NA)	0 (0, 0)					0 (0, 0)	NA (NA, NA)	0.071 (0.014, 0.127)	0.074 (0.015, 0.075)					NA (NA, NA)	NA (NA, NA)	0.185 (0.185, 0.185)	NA (NA, NA)
TP53+	TC4	count					1	1	1	1					1	1	1	1					1	1	1	1					1	1	1	1
TP53+	TC4	time					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)
TP53+	TC4	n					4 (4, 4)	6 (6, 6)	2 (2, 2)	5 (5, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)					0 (0, 0)	0 (0, 0)	3 (3, 3)	4 (4, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.58 (0.58, 0.58)	0.71 (0.71, 0.71)	0.54 (0.54, 0.54)	0.58 (0.58, 0.58)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)					NA (NA, NA)	NA (NA, NA)	0.75 (0.75, 0.75)	0.54 (0.54, 0.54)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.056 (0.056, 0.056)	0 (0, 0)	0.239 (0.239, 0.239)	0.089 (0.089, 0.089)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.251 (0.251, 0.251)					NA (NA, NA)	NA (NA, NA)	0.058 (0.058, 0.058)	0.043 (0.043, 0.043)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	count					61	61	61	61					61	61	61	61					61	61	61	61					61	61	61	61
TP53+	TC5	time					16 (12, 25)	16 (12, 25)	16 (12, 25)	16 (12, 25)					16 (12, 25)	16 (12, 25)	16 (12, 25)	16 (12, 25)					16 (12, 25)	16 (12, 25)	16 (12, 25)	16 (12, 25)					16 (12, 25)	16 (12, 25)	16 (12, 25)	16 (12, 25)
TP53+	TC5	n					5 (2, 13)	8 (4, 13)	1 (0, 3)	6 (3, 9)					0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	4 (1, 8)	5 (2, 10)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.7 (0.52, 0.85)	0.82 (0.65, 0.96)	0.56 (0.51, 0.69)	0.76 (0.55, 0.95)					NA (NA, NA)	0.55 (0.52, 0.62)	NA (NA, NA)	0.57 (0.51, 0.65)					0.56 (0.54, 0.59)	NA (NA, NA)	0.66 (0.52, 0.82)	0.72 (0.56, 0.93)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.073 (0.022, 0.111)	0.038 (0, 0.067)	0.063 (0, 0.169)	0.033 (0, 0.072)					0 (0, 0)	0 (0, 0.167)	NA (NA, NA)	0 (0, 0.18)					0 (0, 0.251)	0.233 (0.047, 0.42)	0.065 (0, 0.125)	0.03 (0, 0.07)					0.055 (0.011, 0.529)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			3	3			3	3			3	3			3	3			3	3			3	3			3	3			3	3
TEfus+	TC1	time			15 (12, 17)	15 (12, 17)			15 (12, 17)	15 (12, 17)			15 (12, 17)	15 (12, 17)			15 (12, 17)	15 (12, 17)			15 (12, 17)	15 (12, 17)			15 (12, 17)	15 (12, 17)			15 (12, 17)	15 (12, 17)			15 (12, 17)	15 (12, 17)
TEfus+	TC1	n			1 (0, 3)	4 (3, 5)			1 (0, 2)	4 (1, 4)			3 (2, 3)	0 (0, 0)			0 (0, 0)	0 (0, 0)			2 (1, 4)	2 (2, 2)			5 (4, 7)	3 (3, 4)			0 (0, 0)	1 (0, 1)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.56 (0.56, 0.56)	0.81 (0.73, 0.83)			0.52 (0.52, 0.52)	0.67 (0.57, 0.77)			0.61 (0.54, 0.78)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.58 (0.56, 0.72)	0.53 (0.51, 0.55)			0.53 (0.51, 0.7)	0.53 (0.53, 0.57)			NA (NA, NA)	0.54 (0.54, 0.54)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.037 (0.007, 0.067)	0.091 (0.018, 0.095)			0 (0, 0)	0.058 (0.04, 0.075)			0 (0, 0.067)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.113 (0.023, 0.151)	0.07 (0.063, 0.09)			0.074 (0.054, 0.122)	0.085 (0.076, 0.097)			NA (NA, NA)	0.542 (0.215, 0.869)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			3	3			3	3			3	3			3	3			3	3			3	3			3	3			3	3
TEfus+	TC3	time			19 (17, 21)	19 (17, 21)			19 (17, 21)	19 (17, 21)			19 (17, 21)	19 (17, 21)			19 (17, 21)	19 (17, 21)			19 (17, 21)	19 (17, 21)			19 (17, 21)	19 (17, 21)			19 (17, 21)	19 (17, 21)			19 (17, 21)	19 (17, 21)
TEfus+	TC3	n			0 (0, 0)	1 (0, 2)			1 (1, 2)	5 (3, 8)			4 (2, 7)	1 (0, 1)			0 (0, 0)	1 (0, 1)			2 (2, 3)	0 (0, 2)			3 (1, 9)	5 (3, 5)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 1)
TEfus+	TC3	post_p			NA (NA, NA)	0.52 (0.52, 0.54)			0.56 (0.53, 0.6)	0.56 (0.52, 0.67)			0.77 (0.62, 0.79)	0.59 (0.58, 0.61)			NA (NA, NA)	0.52 (0.52, 0.52)			0.67 (0.66, 0.87)	0.57 (0.57, 0.57)			0.72 (0.58, 0.73)	0.65 (0.59, 0.67)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			NA (NA, NA)	0.028 (0.006, 0.05)			0.078 (0.016, 0.127)	0.039 (0.039, 0.082)			0.061 (0.049, 0.074)	0 (0, 0)			NA (NA, NA)	0.134 (0.112, 0.156)			0 (0, 0.038)	0 (0, 0)			0.051 (0.01, 0.066)	0.079 (0.041, 0.087)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)
TEfus+	TC4	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC4	time			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)
TEfus+	TC4	n			0 (0, 0)	3 (3, 3)			2 (2, 2)	1 (1, 1)			5 (5, 5)	2 (2, 2)			0 (0, 0)	2 (2, 2)			1 (1, 1)	1 (1, 1)			4 (4, 4)	3 (3, 3)			1 (1, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			NA (NA, NA)	0.57 (0.57, 0.57)			0.57 (0.57, 0.57)	0.51 (0.51, 0.51)			0.8 (0.8, 0.8)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	0.54 (0.54, 0.54)			0.84 (0.84, 0.84)	0.61 (0.61, 0.61)			0.55 (0.55, 0.55)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			NA (NA, NA)	0 (0, 0)			0 (0, 0)	0.117 (0.117, 0.117)			0.037 (0.037, 0.037)	0.057 (0.057, 0.057)			NA (NA, NA)	0.666 (0.666, 0.666)			0.951 (0.951, 0.951)	0 (0, 0)			0 (0, 0)	0.07 (0.07, 0.07)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	count			34	34			34	34			34	34			34	34			34	34			34	34			34	34			34	34
TEfus+	TC5	time			16 (12, 27)	16 (12, 27)			16 (12, 27)	16 (12, 27)			16 (12, 27)	16 (12, 27)			16 (12, 27)	16 (12, 27)			16 (12, 27)	16 (12, 27)			16 (12, 27)	16 (12, 27)			16 (12, 27)	16 (12, 27)			16 (12, 27)	16 (12, 27)
TEfus+	TC5	n			1 (0, 4)	4 (2, 8)			1 (0, 4)	6 (3, 9)			2 (0, 4)	1 (0, 3)			0 (0, 0)	0 (0, 1)			1 (0, 3)	1 (0, 3)			4 (1, 8)	5 (3, 8)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.57 (0.52, 0.64)	0.72 (0.54, 0.86)			0.55 (0.51, 0.62)	0.77 (0.6, 0.95)			0.57 (0.52, 0.78)	0.58 (0.53, 0.7)			NA (NA, NA)	0.61 (0.51, 0.73)			0.56 (0.5, 0.67)	0.59 (0.55, 0.63)			0.66 (0.54, 0.82)	0.72 (0.55, 0.9)			0.59 (0.59, 0.59)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.057 (0, 0.184)	0.034 (0, 0.062)			0.055 (0, 0.132)	0.036 (0, 0.086)			0.061 (0, 0.109)	0 (0, 0.043)			NA (NA, NA)	0 (0, 0.206)			0.062 (0, 0.162)	0 (0, 0.058)			0.061 (0, 0.12)	0.036 (0, 0.062)			0 (0, 3.963)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC2	count		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1
PI3K+	TC2	time		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)		17 (17, 17)
PI3K+	TC2	n		5 (5, 5)		3 (3, 3)		4 (4, 4)		4 (4, 4)		0 (0, 0)		1 (1, 1)		1 (1, 1)		3 (3, 3)		1 (1, 1)		2 (2, 2)		0 (0, 0)		2 (2, 2)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.52 (0.52, 0.52)		0.72 (0.72, 0.72)		0.52 (0.52, 0.52)		0.53 (0.53, 0.53)		NA (NA, NA)		NA (NA, NA)		0.55 (0.55, 0.55)		0.67 (0.67, 0.67)		NA (NA, NA)		0.56 (0.56, 0.56)		NA (NA, NA)		0.54 (0.54, 0.54)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.108 (0.108, 0.108)		0 (0, 0)		0.056 (0.056, 0.056)		0.071 (0.071, 0.071)		NA (NA, NA)		0.202 (0.202, 0.202)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.214 (0.214, 0.214)		NA (NA, NA)		0.093 (0.093, 0.093)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	count		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1
PI3K+	TC3	time		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)		16 (16, 16)
PI3K+	TC3	n		8 (8, 8)		2 (2, 2)		8 (8, 8)		5 (5, 5)		0 (0, 0)		0 (0, 0)		0 (0, 0)		2 (2, 2)		0 (0, 0)		0 (0, 0)		0 (0, 0)		6 (6, 6)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.83 (0.83, 0.83)		0.56 (0.56, 0.56)		0.76 (0.76, 0.76)		0.65 (0.65, 0.65)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.52 (0.52, 0.52)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.73 (0.73, 0.73)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.048 (0.048, 0.048)		0.078 (0.078, 0.078)		0.037 (0.037, 0.037)		0 (0, 0)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.162 (0.162, 0.162)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.09 (0.09, 0.09)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC4	time		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)		17 (14, 20)
PI3K+	TC4	n		10 (6, 13)		2 (1, 3)		6 (4, 8)		1 (0, 2)		0 (0, 0)		4 (4, 4)		2 (1, 3)		2 (1, 2)		1 (0, 2)		2 (1, 2)		0 (0, 0)		1 (0, 2)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.68 (0.55, 0.81)		0.62 (0.57, 0.67)		0.75 (0.58, 0.92)		0.53 (0.53, 0.53)		NA (NA, NA)		0.57 (0.52, 0.62)		NA (NA, NA)		0.52 (0.52, 0.52)		NA (NA, NA)		0.65 (0.55, 0.76)		NA (NA, NA)		0.55 (0.55, 0.55)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.069 (0.063, 0.075)		0 (0, 0)		0.099 (0.065, 0.134)		0.073 (0.073, 0.073)		NA (NA, NA)		0.085 (0.074, 0.095)		0.226 (0.17, 0.282)		0.047 (0.009, 0.085)		0.039 (0.039, 0.039)		0.019 (0.004, 0.035)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	count		312		312		312		312		312		312		312		312		312		312		312		312		312		312		312		312
PI3K+	TC5	time		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)		17 (11, 28)
PI3K+	TC5	n		11 (5, 23)		4 (2, 10)		9 (4, 18)		7 (3, 13)		0 (0, 0)		1 (0, 3)		0 (0, 2)		0 (0, 2)		1 (0, 2)		1 (0, 4)		0 (0, 0)		5 (2, 12)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.86 (0.68, 1)		0.72 (0.54, 0.94)		0.82 (0.6, 0.99)		0.75 (0.54, 0.98)		NA (NA, NA)		0.59 (0.52, 0.8)		0.56 (0.52, 0.72)		0.57 (0.51, 0.69)		0.56 (0.51, 0.67)		0.58 (0.52, 0.75)		NA (NA, NA)		0.74 (0.55, 0.96)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.036 (0, 0.065)		0.036 (0, 0.082)		0.036 (0, 0.069)		0.033 (0, 0.077)		0 (0, 0)		0 (0, 0.11)		0 (0, 0.121)		0 (0, 0.098)		0 (0, 0.119)		0 (0, 0.123)		0 (0, 0.262)		0.036 (0, 0.077)		0.166 (0.166, 0.166)		0 (0, 0)		0 (0, 0.092)		0 (0, 0)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
all	TC1	time	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)	4 (4, 22)
all	TC1	n	18 (15, 22)	2 (1, 4)	0 (0, 3)	0 (0, 3)	4 (1, 8)	2 (0, 6)	0 (0, 2)	0 (0, 3)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	1 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	1 (0, 3)	2 (0, 3)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.39 (0.2, 0.47)	0.43 (0.32, 0.49)	0.34 (0.27, 0.42)	0.38 (0.2, 0.4)	0.41 (0.29, 0.48)	0.46 (0.4, 0.49)	0.39 (0.37, 0.45)	0.42 (0.37, 0.46)	0.38 (0.24, 0.47)	NA (NA, NA)	0.42 (0.42, 0.42)	0.45 (0.45, 0.46)	NA (NA, NA)	0.4 (0.4, 0.4)	NA (NA, NA)	NA (NA, NA)	0.41 (0.36, 0.42)	NA (NA, NA)	0.44 (0.39, 0.48)	0.34 (0.34, 0.34)	NA (NA, NA)	NA (NA, NA)	0.43 (0.32, 0.48)	0.42 (0.3, 0.46)	0.44 (0.43, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.132 (0.098, 0.229)	0.261 (0.074, 0.676)	0.147 (0, 0.22)	0.41 (0.186, 0.462)	0.152 (0, 0.335)	0.086 (0, 1.759)	0.22 (0.215, 0.229)	0.255 (0.124, 0.579)	0.782 (0.067, 28.623)	NA (NA, NA)	0.122 (0.122, 0.122)	0.151 (0.145, 0.158)	NA (NA, NA)	0.281 (0.056, 0.505)	NA (NA, NA)	0 (0, 0)	0.203 (0, 1.673)	0.474 (0.203, 7.183)	0 (0, 1.785)	0.103 (0.021, 0.186)	NA (NA, NA)	NA (NA, NA)	0.287 (0.064, 0.435)	0.121 (0, 0.19)	0.038 (0.008, 0.416)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.118 (0.118, 0.118)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC2	time	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)	12 (7, 17)
all	TC2	n	12 (9, 36)	1 (0, 2)	1 (0, 2)	0 (0, 1)	4 (2, 4)	3 (1, 4)	2 (1, 2)	3 (2, 4)	4 (1, 5)	0 (0, 0)	2 (0, 3)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 3)	1 (0, 2)	0 (0, 2)	3 (1, 4)	0 (0, 1)	0 (0, 1)	0 (0, 0)	6 (5, 6)	2 (1, 4)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)
all	TC2	post_p	0.31 (0.15, 0.49)	0.39 (0.28, 0.41)	0.46 (0.41, 0.47)	0.4 (0.4, 0.4)	0.46 (0.29, 0.49)	0.43 (0.41, 0.46)	0.42 (0.42, 0.43)	0.44 (0.38, 0.47)	0.41 (0.33, 0.44)	NA (NA, NA)	0.34 (0.32, 0.37)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.43 (0.39, 0.46)	0.46 (0.42, 0.49)	0.5 (0.5, 0.5)	0.39 (0.36, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.37 (0.21, 0.42)	0.41 (0.34, 0.45)	0.44 (0.44, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.15 (0.112, 0.186)	0.289 (0.247, 0.958)	0.591 (0.273, 1.343)	0.302 (0.302, 0.302)	0.102 (0.028, 0.235)	0.106 (0.095, 0.195)	0.142 (0.038, 0.171)	0.144 (0.122, 0.267)	0.12 (0.118, 0.336)	NA (NA, NA)	0.155 (0.031, 0.242)	0.313 (0.063, 0.564)	NA (NA, NA)	0.441 (0.441, 0.441)	NA (NA, NA)	0.522 (0.202, 0.842)	0.138 (0.091, 0.184)	0.272 (0.054, 0.49)	0.157 (0.111, 0.164)	0 (0, 0)	0.082 (0.082, 0.082)	NA (NA, NA)	0.175 (0.138, 0.201)	0.212 (0.168, 1.386)	7.544 (7.544, 7.544)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
all	TC3	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC3	time	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)
all	TC3	n	9 (7, 11)	6 (1, 10)	0 (0, 0)	3 (2, 4)	7 (3, 11)	2 (1, 2)	1 (0, 2)	6 (3, 8)	4 (3, 6)	0 (0, 0)	4 (4, 5)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	1 (1, 1)	0 (0, 0)	2 (1, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	6 (3, 10)	2 (1, 4)	1 (1, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.33 (0.22, 0.44)	0.31 (0.31, 0.31)	NA (NA, NA)	0.42 (0.41, 0.43)	0.45 (0.42, 0.49)	0.3 (0.25, 0.34)	0.23 (0.23, 0.23)	0.41 (0.35, 0.46)	0.26 (0.15, 0.37)	NA (NA, NA)	0.31 (0.3, 0.32)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.43 (0.43, 0.43)	0.39 (0.38, 0.4)	NA (NA, NA)	0.36 (0.34, 0.38)	0.36 (0.36, 0.36)	NA (NA, NA)	NA (NA, NA)	0.47 (0.46, 0.47)	0.4 (0.39, 0.41)	0.38 (0.33, 0.43)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.19 (0.155, 0.224)	0.156 (0.156, 0.156)	NA (NA, NA)	0.147 (0.143, 0.151)	0.116 (0.106, 0.125)	0.518 (0.456, 0.579)	1.236 (1.236, 1.236)	0.354 (0.14, 0.568)	0.202 (0.199, 0.205)	NA (NA, NA)	0.238 (0.191, 0.285)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.07 (0.07, 0.07)	0.188 (0.188, 0.188)	0.551 (0.33, 0.773)	NA (NA, NA)	0.607 (0.335, 0.88)	0.348 (0.348, 0.348)	0.152 (0.152, 0.152)	NA (NA, NA)	0.5 (0.19, 0.811)	3.945 (0.894, 6.997)	5.065 (1.759, 8.371)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	1.014 (1.014, 1.014)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	104	104	104	104					104	104	104	104
AR- & TP53-	TC1	time	13 (5, 25)	13 (5, 25)	13 (5, 25)	13 (5, 25)					13 (5, 25)	13 (5, 25)	13 (5, 25)	13 (5, 25)
AR- & TP53-	TC1	n	22 (15, 45)	5 (2, 10)	1 (0, 4)	2 (0, 6)					3 (0, 8)	0 (0, 0)	1 (0, 5)	0 (0, 2)
AR- & TP53-	TC1	post_p	0.31 (0.12, 0.46)	0.37 (0.18, 0.48)	0.42 (0.31, 0.48)	0.41 (0.25, 0.49)					0.41 (0.21, 0.48)	NA (NA, NA)	0.4 (0.24, 0.48)	0.45 (0.35, 0.49)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.129 (0.105, 0.176)	0.152 (0.086, 0.361)	0.188 (0.062, 0.73)	0.16 (0.059, 0.457)					0.172 (0.102, 0.429)	0.147 (0.029, 0.643)	0.205 (0.087, 0.719)	0.156 (0, 0.656)
AR- & TP53-	TC2	count	79	79	79	79					79	79	79	79
AR- & TP53-	TC2	time	20 (12, 33)	20 (12, 33)	20 (12, 33)	20 (12, 33)					20 (12, 33)	20 (12, 33)	20 (12, 33)	20 (12, 33)
AR- & TP53-	TC2	n	20 (10, 72)	5 (2, 13)	1 (0, 3)	3 (1, 6)					5 (1, 10)	0 (0, 0)	3 (1, 6)	1 (0, 3)
AR- & TP53-	TC2	post_p	0.3 (0.07, 0.48)	0.36 (0.17, 0.47)	0.42 (0.3, 0.48)	0.39 (0.23, 0.48)					0.37 (0.21, 0.48)	NA (NA, NA)	0.37 (0.19, 0.47)	0.43 (0.34, 0.49)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.128 (0.105, 0.219)	0.153 (0.094, 0.363)	0.206 (0.074, 1.361)	0.163 (0.095, 0.367)					0.158 (0.101, 0.544)	0.241 (0.048, 0.434)	0.198 (0.112, 0.733)	0.166 (0, 0.542)
AR- & TP53-	TC3	count	68	68	68	68					68	68	68	68
AR- & TP53-	TC3	time	22 (12, 31)	22 (12, 31)	22 (12, 31)	22 (12, 31)					22 (12, 31)	22 (12, 31)	22 (12, 31)	22 (12, 31)
AR- & TP53-	TC3	n	18 (8, 55)	4 (2, 13)	1 (0, 3)	3 (1, 6)					6 (4, 15)	0 (0, 0)	4 (1, 7)	2 (0, 4)
AR- & TP53-	TC3	post_p	0.31 (0.11, 0.46)	0.36 (0.17, 0.47)	0.45 (0.36, 0.49)	0.4 (0.2, 0.48)					0.34 (0.15, 0.47)	NA (NA, NA)	0.38 (0.21, 0.47)	0.41 (0.29, 0.48)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.132 (0.109, 0.197)	0.162 (0.109, 0.338)	0.175 (0.074, 0.62)	0.162 (0.091, 0.729)					0.166 (0.1, 0.289)	0.3 (0.266, 0.53)	0.183 (0.087, 0.419)	0.199 (0.064, 1.427)
AR- & TP53-	TC4	count	78	78	78	78					78	78	78	78
AR- & TP53-	TC4	time	16 (11, 29)	16 (11, 29)	16 (11, 29)	16 (11, 29)					16 (11, 29)	16 (11, 29)	16 (11, 29)	16 (11, 29)
AR- & TP53-	TC4	n	19 (8, 45)	4 (1, 11)	1 (0, 2)	2 (1, 6)					6 (3, 14)	0 (0, 0)	4 (1, 7)	1 (0, 4)
AR- & TP53-	TC4	post_p	0.32 (0.14, 0.45)	0.38 (0.18, 0.48)	0.41 (0.32, 0.47)	0.39 (0.23, 0.47)					0.32 (0.17, 0.46)	NA (NA, NA)	0.41 (0.2, 0.49)	0.4 (0.28, 0.46)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.139 (0.107, 0.214)	0.154 (0.087, 0.399)	0.195 (0, 0.89)	0.202 (0.103, 0.575)					0.161 (0.105, 0.293)	0.155 (0.042, 0.25)	0.16 (0.095, 0.346)	0.2 (0.057, 0.786)
AR- & TP53-	TC5	count	2	2	2	2					2	2	2	2
AR- & TP53-	TC5	time	26 (18, 33)	26 (18, 33)	26 (18, 33)	26 (18, 33)					26 (18, 33)	26 (18, 33)	26 (18, 33)	26 (18, 33)
AR- & TP53-	TC5	n	8 (7, 8)	18 (8, 27)	1 (0, 2)	4 (2, 6)					8 (4, 12)	0 (0, 0)	4 (4, 4)	2 (1, 3)
AR- & TP53-	TC5	post_p	0.12 (0.08, 0.15)	0.44 (0.42, 0.46)	0.5 (0.5, 0.5)	0.35 (0.26, 0.45)					0.28 (0.12, 0.45)	NA (NA, NA)	0.35 (0.32, 0.38)	0.32 (0.32, 0.32)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.24 (0.232, 0.249)	0.078 (0.055, 0.101)	0.09 (0.09, 0.09)	0.209 (0.112, 0.306)					0.219 (0.126, 0.311)	NA (NA, NA)	0.188 (0.171, 0.206)	0.074 (0.015, 0.133)
HRD+	TC1	count									13	13	13	13	13	13	13	13									13	13	13	13	13	13	13	13
HRD+	TC1	time									29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)									29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)	29 (27, 36)
HRD+	TC1	n									10 (7, 17)	0 (0, 1)	5 (3, 10)	2 (0, 5)	0 (0, 0)	2 (1, 5)	0 (0, 0)	2 (0, 4)									4 (2, 7)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.37 (0.16, 0.48)	NA (NA, NA)	0.29 (0.12, 0.45)	0.37 (0.28, 0.47)	NA (NA, NA)	0.42 (0.33, 0.49)	NA (NA, NA)	0.37 (0.22, 0.46)									0.37 (0.19, 0.44)	NA (NA, NA)	0.5 (0.49, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.131 (0.106, 0.188)	0.213 (0.13, 0.296)	0.167 (0.122, 0.395)	0.252 (0.075, 0.566)	NA (NA, NA)	0.161 (0.111, 0.411)	NA (NA, NA)	0.223 (0.087, 1.134)									0.158 (0.12, 0.25)	NA (NA, NA)	0.105 (0.074, 0.137)	0.82 (0.82, 0.82)	0.074 (0.015, 0.133)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									16	16	16	16	16	16	16	16									16	16	16	16	16	16	16	16
HRD+	TC2	time									32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)									32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)	32 (26, 34)
HRD+	TC2	n									13 (7, 22)	0 (0, 0)	5 (2, 11)	3 (1, 5)	0 (0, 0)	2 (0, 3)	0 (0, 0)	1 (0, 2)									4 (1, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.36 (0.16, 0.49)	NA (NA, NA)	0.33 (0.19, 0.48)	0.38 (0.24, 0.48)	NA (NA, NA)	0.41 (0.32, 0.46)	NA (NA, NA)	0.44 (0.39, 0.48)									0.4 (0.35, 0.49)	NA (NA, NA)	0.47 (0.44, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.126 (0.103, 0.219)	NA (NA, NA)	0.165 (0.101, 0.245)	0.186 (0.098, 0.506)	NA (NA, NA)	0.164 (0.046, 0.246)	NA (NA, NA)	0.211 (0.068, 0.827)									0.141 (0.114, 0.714)	0.207 (0.041, 0.373)	0.13 (0.093, 0.522)	0.527 (0.527, 0.527)	0.26 (0.26, 0.26)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									38	38	38	38	38	38	38	38									38	38	38	38	38	38	38	38
HRD+	TC3	time									30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)									30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)	30 (22, 35)
HRD+	TC3	n									12 (6, 20)	0 (0, 0)	6 (3, 10)	2 (1, 4)	0 (0, 0)	1 (0, 3)	0 (0, 0)	2 (0, 3)									4 (1, 7)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.38 (0.2, 0.48)	0.48 (0.48, 0.48)	0.38 (0.21, 0.48)	0.36 (0.22, 0.44)	NA (NA, NA)	0.41 (0.3, 0.47)	NA (NA, NA)	0.42 (0.32, 0.49)									0.39 (0.27, 0.48)	NA (NA, NA)	0.43 (0.37, 0.49)	NA (NA, NA)	0.46 (0.45, 0.48)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.122 (0.097, 0.177)	0.104 (0.021, 0.158)	0.141 (0.109, 0.281)	0.219 (0.099, 0.427)	0.095 (0.095, 0.095)	0.217 (0.112, 0.86)	0.187 (0.172, 0.202)	0.17 (0.105, 0.811)									0.185 (0.1, 0.597)	NA (NA, NA)	0.287 (0.012, 1.38)	0.091 (0.091, 0.091)	0.079 (0, 0.206)	0 (0, 0)	0.048 (0, 1.401)	NA (NA, NA)
HRD+	TC4	count									34	34	34	34	34	34	34	34									34	34	34	34	34	34	34	34
HRD+	TC4	time									28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)									28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)	28 (21, 34)
HRD+	TC4	n									10 (6, 17)	0 (0, 0)	6 (3, 10)	3 (1, 4)	0 (0, 0)	1 (0, 4)	0 (0, 0)	2 (0, 3)									4 (2, 9)	0 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.35 (0.21, 0.45)	NA (NA, NA)	0.35 (0.21, 0.47)	0.37 (0.26, 0.47)	NA (NA, NA)	0.41 (0.26, 0.48)	NA (NA, NA)	0.39 (0.26, 0.48)									0.35 (0.27, 0.47)	0.46 (0.46, 0.46)	0.46 (0.34, 0.5)	NA (NA, NA)	0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.139 (0.105, 0.189)	NA (NA, NA)	0.151 (0.12, 0.289)	0.163 (0.09, 0.475)	0.193 (0.193, 0.193)	0.228 (0.1, 1.042)	0.111 (0.022, 0.178)	0.134 (0.084, 0.703)									0.148 (0.1, 0.624)	0.097 (0.019, 0.176)	0.192 (0.014, 2.116)	0.138 (0.138, 0.138)	0.039 (0, 0.719)	NA (NA, NA)	0.163 (0.163, 0.163)	0.246 (0.177, 1.188)
HRD+	TC5	count									2	2	2	2	2	2	2	2									2	2	2	2	2	2	2	2
HRD+	TC5	time									32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)									32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)
HRD+	TC5	n									10 (5, 14)	0 (0, 0)	10 (4, 15)	1 (0, 2)	0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (1, 1)									4 (2, 6)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.19 (0.17, 0.22)	NA (NA, NA)	0.47 (0.46, 0.49)	0.49 (0.49, 0.49)	NA (NA, NA)	0.37 (0.37, 0.37)	NA (NA, NA)	NA (NA, NA)									0.34 (0.34, 0.34)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.206 (0.144, 0.269)	NA (NA, NA)	0.094 (0.082, 0.106)	0.13 (0.13, 0.13)	NA (NA, NA)	0.232 (0.232, 0.232)	NA (NA, NA)	0.601 (0.12, 1.082)									0.51 (0.406, 0.614)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					55	55	55	55					55	55	55	55					55	55	55	55					55	55	55	55
TP53+	TC1	time					22 (15, 31)	22 (15, 31)	22 (15, 31)	22 (15, 31)					22 (15, 31)	22 (15, 31)	22 (15, 31)	22 (15, 31)					22 (15, 31)	22 (15, 31)	22 (15, 31)	22 (15, 31)					22 (15, 31)	22 (15, 31)	22 (15, 31)	22 (15, 31)
TP53+	TC1	n					8 (4, 15)	6 (3, 10)	2 (0, 5)	5 (2, 9)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	5 (2, 9)	4 (1, 8)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.36 (0.12, 0.49)	0.32 (0.14, 0.47)	0.42 (0.25, 0.48)	0.36 (0.21, 0.48)					NA (NA, NA)	0.45 (0.41, 0.48)	NA (NA, NA)	0.42 (0.25, 0.48)					0.44 (0.36, 0.46)	NA (NA, NA)	0.36 (0.14, 0.48)	0.38 (0.3, 0.48)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.139 (0.102, 0.342)	0.145 (0.089, 0.313)	0.214 (0.102, 1.2)	0.151 (0.099, 0.301)					0.204 (0.041, 0.367)	0.167 (0, 3.224)	15.128 (15.128, 15.128)	0.124 (0, 0.44)					0.17 (0, 1.172)	NA (NA, NA)	0.168 (0.11, 0.378)	0.143 (0.1, 0.54)					0.303 (0.137, 2.222)	0 (0, 0)	1.176 (1.176, 1.176)	0.24 (0.048, 0.279)
TP53+	TC2	count					52	52	52	52					52	52	52	52					52	52	52	52					52	52	52	52
TP53+	TC2	time					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)
TP53+	TC2	n					6 (3, 13)	5 (2, 11)	2 (0, 6)	4 (2, 10)					0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)					1 (0, 2)	0 (0, 0)	6 (3, 12)	4 (2, 8)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.3 (0.16, 0.45)	0.36 (0.21, 0.5)	0.42 (0.23, 0.48)	0.36 (0.16, 0.48)					NA (NA, NA)	0.46 (0.35, 0.49)	NA (NA, NA)	0.42 (0.37, 0.47)					0.48 (0.44, 0.5)	NA (NA, NA)	0.34 (0.18, 0.48)	0.32 (0.21, 0.44)					0.43 (0.41, 0.45)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.156 (0.113, 0.342)	0.142 (0.079, 0.27)	0.183 (0.089, 0.724)	0.145 (0.074, 0.492)					0.235 (0.154, 0.316)	0.12 (0.013, 1.211)	0 (0, 0)	0.146 (0, 0.874)					0.125 (0, 1.117)	0.124 (0.025, 0.223)	0.15 (0.099, 0.274)	0.166 (0.104, 0.348)					0.827 (0.472, 1.364)	3.356 (3.356, 3.356)	4.558 (4.558, 4.558)	NA (NA, NA)
TP53+	TC3	count					44	44	44	44					44	44	44	44					44	44	44	44					44	44	44	44
TP53+	TC3	time					24 (17, 34)	24 (17, 34)	24 (17, 34)	24 (17, 34)					24 (17, 34)	24 (17, 34)	24 (17, 34)	24 (17, 34)					24 (17, 34)	24 (17, 34)	24 (17, 34)	24 (17, 34)					24 (17, 34)	24 (17, 34)	24 (17, 34)	24 (17, 34)
TP53+	TC3	n					6 (3, 14)	5 (2, 11)	2 (0, 3)	4 (2, 10)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 1)	0 (0, 0)	6 (2, 11)	5 (2, 11)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.28 (0.14, 0.48)	0.3 (0.15, 0.46)	0.41 (0.24, 0.47)	0.38 (0.23, 0.47)					NA (NA, NA)	0.43 (0.32, 0.48)	NA (NA, NA)	0.43 (0.37, 0.49)					0.45 (0.31, 0.47)	NA (NA, NA)	0.3 (0.17, 0.46)	0.39 (0.24, 0.46)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.46 (0.46, 0.46)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.144 (0.104, 0.334)	0.155 (0.1, 0.444)	0.233 (0.143, 0.416)	0.147 (0.092, 0.345)					NA (NA, NA)	0.174 (0.076, 0.655)	1.919 (0.73, 3.107)	0.155 (0.08, 0.336)					0.309 (0, 0.927)	0.129 (0.127, 0.131)	0.172 (0.109, 0.569)	0.135 (0.105, 0.254)					1.134 (0, 17.925)	0.333 (0.067, 0.6)	0.094 (0.094, 0.094)	0.203 (0.041, 0.365)
TP53+	TC4	count					41	41	41	41					41	41	41	41					41	41	41	41					41	41	41	41
TP53+	TC4	time					27 (18, 33)	27 (18, 33)	27 (18, 33)	27 (18, 33)					27 (18, 33)	27 (18, 33)	27 (18, 33)	27 (18, 33)					27 (18, 33)	27 (18, 33)	27 (18, 33)	27 (18, 33)					27 (18, 33)	27 (18, 33)	27 (18, 33)	27 (18, 33)
TP53+	TC4	n					8 (3, 14)	5 (2, 10)	2 (0, 4)	4 (2, 10)					0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)					0 (0, 2)	0 (0, 0)	5 (3, 11)	4 (1, 8)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.41 (0.17, 0.48)	0.3 (0.16, 0.44)	0.41 (0.31, 0.48)	0.35 (0.16, 0.47)					NA (NA, NA)	0.46 (0.3, 0.48)	NA (NA, NA)	0.44 (0.37, 0.47)					0.45 (0.39, 0.48)	NA (NA, NA)	0.37 (0.21, 0.49)	0.36 (0.2, 0.48)					0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.149 (0.103, 0.305)	0.162 (0.097, 0.356)	0.208 (0.104, 0.498)	0.157 (0.103, 0.412)					0.133 (0.133, 0.133)	0.175 (0.089, 0.44)	0.112 (0.067, 0.156)	0.178 (0.048, 0.408)					0.218 (0.108, 0.686)	0.098 (0.098, 0.098)	0.155 (0.103, 0.342)	0.182 (0.097, 0.52)					0.132 (0, 0.986)	0 (0, 0)	0.259 (0.259, 0.259)	0 (0, 0)
TEfus+	TC1	count			29	29			29	29			29	29			29	29			29	29			29	29			29	29			29	29
TEfus+	TC1	time			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)			22 (16, 29)	22 (16, 29)
TEfus+	TC1	n			2 (1, 4)	3 (1, 5)			2 (1, 5)	5 (2, 9)			2 (0, 6)	1 (0, 2)			0 (0, 0)	1 (0, 2)			2 (1, 4)	1 (0, 3)			6 (3, 9)	4 (3, 8)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.4 (0.24, 0.45)	0.32 (0.2, 0.46)			0.4 (0.24, 0.46)	0.26 (0.21, 0.38)			0.39 (0.22, 0.47)	0.43 (0.31, 0.46)			NA (NA, NA)	0.4 (0.3, 0.48)			0.41 (0.27, 0.47)	0.41 (0.3, 0.46)			0.36 (0.21, 0.48)	0.34 (0.23, 0.48)			0.41 (0.4, 0.41)	NA (NA, NA)			NA (NA, NA)	0.49 (0.49, 0.49)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.174 (0.096, 0.513)	0.162 (0.098, 0.419)			0.216 (0.121, 0.813)	0.169 (0.111, 0.427)			0.243 (0.122, 0.612)	0.19 (0.091, 0.557)			0 (0, 0)	0.151 (0, 0.338)			0.219 (0.102, 2.019)	0.167 (0.047, 0.713)			0.161 (0.095, 0.299)	0.163 (0.108, 0.278)			0.341 (0.066, 0.641)	4.278 (4.278, 4.278)			NA (NA, NA)	0 (0, 0)
TEfus+	TC2	count			26	26			26	26			26	26			26	26			26	26			26	26			26	26			26	26
TEfus+	TC2	time			24 (14, 30)	24 (14, 30)			24 (14, 30)	24 (14, 30)			24 (14, 30)	24 (14, 30)			24 (14, 30)	24 (14, 30)			24 (14, 30)	24 (14, 30)			24 (14, 30)	24 (14, 30)			24 (14, 30)	24 (14, 30)			24 (14, 30)	24 (14, 30)
TEfus+	TC2	n			1 (0, 4)	2 (0, 6)			3 (0, 5)	4 (2, 10)			3 (0, 6)	1 (0, 3)			0 (0, 0)	1 (0, 2)			3 (0, 5)	1 (0, 4)			6 (4, 11)	5 (3, 8)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.43 (0.3, 0.48)	0.36 (0.27, 0.49)			0.41 (0.29, 0.48)	0.33 (0.18, 0.48)			0.36 (0.24, 0.47)	0.44 (0.32, 0.49)			NA (NA, NA)	0.43 (0.39, 0.47)			0.39 (0.22, 0.48)	0.42 (0.27, 0.48)			0.33 (0.19, 0.47)	0.38 (0.2, 0.48)			0.47 (0.46, 0.49)	0.48 (0.48, 0.48)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.227 (0.085, 1.873)	0.163 (0.081, 0.333)			0.169 (0.104, 0.349)	0.138 (0.084, 0.281)			0.192 (0.134, 1.007)	0.182 (0, 1.077)			NA (NA, NA)	0.24 (0.087, 0.577)			0.172 (0.109, 0.349)	0.277 (0.057, 0.457)			0.141 (0.1, 0.288)	0.158 (0.094, 0.308)			0.157 (0.078, 0.524)	0.431 (0.431, 0.431)			2.279 (0.456, 4.102)	NA (NA, NA)
TEfus+	TC3	count			18	18			18	18			18	18			18	18			18	18			18	18			18	18			18	18
TEfus+	TC3	time			30 (18, 35)	30 (18, 35)			30 (18, 35)	30 (18, 35)			30 (18, 35)	30 (18, 35)			30 (18, 35)	30 (18, 35)			30 (18, 35)	30 (18, 35)			30 (18, 35)	30 (18, 35)			30 (18, 35)	30 (18, 35)			30 (18, 35)	30 (18, 35)
TEfus+	TC3	n			1 (0, 4)	4 (1, 9)			2 (1, 4)	4 (3, 11)			4 (1, 8)	2 (0, 3)			0 (0, 0)	1 (0, 3)			1 (1, 3)	1 (0, 3)			6 (3, 11)	4 (3, 9)			1 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.43 (0.34, 0.46)	0.37 (0.2, 0.49)			0.4 (0.27, 0.48)	0.4 (0.27, 0.48)			0.33 (0.22, 0.44)	0.38 (0.3, 0.46)			NA (NA, NA)	0.38 (0.27, 0.43)			0.4 (0.31, 0.46)	0.43 (0.35, 0.45)			0.35 (0.2, 0.48)	0.32 (0.18, 0.45)			0.46 (0.45, 0.5)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.177 (0.118, 0.6)	0.149 (0.098, 0.548)			0.176 (0.111, 0.672)	0.142 (0.096, 0.249)			0.2 (0.113, 0.305)	0.201 (0.119, 1.225)			0.251 (0.106, 0.397)	0.166 (0.101, 0.286)			0.307 (0.149, 0.855)	0.175 (0.119, 0.406)			0.145 (0.104, 0.385)	0.127 (0.103, 0.242)			0.066 (0, 0.21)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			22	22			22	22			22	22			22	22			22	22			22	22			22	22			22	22
TEfus+	TC4	time			26 (18, 34)	26 (18, 34)			26 (18, 34)	26 (18, 34)			26 (18, 34)	26 (18, 34)			26 (18, 34)	26 (18, 34)			26 (18, 34)	26 (18, 34)			26 (18, 34)	26 (18, 34)			26 (18, 34)	26 (18, 34)			26 (18, 34)	26 (18, 34)
TEfus+	TC4	n			1 (0, 4)	2 (1, 7)			2 (0, 5)	4 (2, 8)			4 (2, 8)	2 (0, 3)			0 (0, 0)	2 (0, 3)			2 (0, 4)	1 (0, 2)			4 (3, 8)	6 (3, 9)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.4 (0.28, 0.49)	0.33 (0.25, 0.44)			0.38 (0.27, 0.47)	0.37 (0.21, 0.48)			0.37 (0.13, 0.46)	0.37 (0.3, 0.45)			NA (NA, NA)	0.45 (0.29, 0.5)			0.42 (0.26, 0.46)	0.43 (0.38, 0.49)			0.36 (0.24, 0.48)	0.37 (0.26, 0.47)			0.38 (0.33, 0.5)	NA (NA, NA)			NA (NA, NA)	0.48 (0.48, 0.48)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.139 (0.099, 0.485)	0.194 (0.142, 0.411)			0.229 (0.12, 0.738)	0.15 (0.097, 0.426)			0.169 (0.107, 0.319)	0.192 (0.111, 0.479)			0.297 (0.297, 0.297)	0.13 (0.064, 0.421)			0.263 (0.116, 0.593)	0.2 (0.086, 0.977)			0.162 (0.117, 0.207)	0.145 (0.111, 0.232)			0.175 (0, 0.387)	NA (NA, NA)			0.102 (0.102, 0.102)	0 (0, 0)
PI3K+	TC1	count		59		59		59		59		59		59		59		59		59		59		59		59		59		59		59		59
PI3K+	TC1	time		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)		22 (15, 32)
PI3K+	TC1	n		6 (3, 14)		3 (1, 6)		5 (3, 9)		6 (2, 12)		0 (0, 0)		1 (0, 3)		1 (0, 2)		1 (0, 2)		1 (0, 2)		1 (0, 3)		0 (0, 0)		4 (1, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.32 (0.11, 0.46)		0.37 (0.19, 0.48)		0.31 (0.18, 0.44)		0.3 (0.18, 0.47)		NA (NA, NA)		0.42 (0.27, 0.48)		0.44 (0.36, 0.48)		0.41 (0.31, 0.46)		0.46 (0.36, 0.48)		0.43 (0.21, 0.49)		NA (NA, NA)		0.36 (0.21, 0.48)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.49 (0.49, 0.49)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.151 (0.099, 0.337)		0.151 (0.083, 0.421)		0.159 (0.097, 0.344)		0.158 (0.093, 0.282)		0.111 (0.033, 0.153)		0.2 (0.081, 0.703)		0.206 (0, 2.434)		0.199 (0, 1)		0.259 (0.094, 0.797)		0.262 (0.075, 0.812)		0.092 (0.092, 0.092)		0.159 (0.097, 0.375)		0 (0, 0)		2.207 (0.55, 3.864)		NA (NA, NA)		0.174 (0, 0.307)
PI3K+	TC2	count		56		56		56		56		56		56		56		56		56		56		56		56		56		56		56		56
PI3K+	TC2	time		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)
PI3K+	TC2	n		6 (2, 12)		3 (1, 6)		6 (3, 12)		5 (2, 10)		0 (0, 0)		1 (0, 3)		1 (0, 2)		1 (0, 2)		1 (0, 2)		2 (0, 3)		0 (0, 0)		5 (3, 10)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.37 (0.19, 0.48)		0.38 (0.18, 0.49)		0.35 (0.14, 0.48)		0.36 (0.16, 0.47)		NA (NA, NA)		0.44 (0.33, 0.5)		0.43 (0.34, 0.49)		0.44 (0.37, 0.49)		0.44 (0.37, 0.47)		0.42 (0.33, 0.48)		NA (NA, NA)		0.34 (0.18, 0.48)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.148 (0.099, 0.362)		0.173 (0.093, 0.397)		0.145 (0.093, 0.246)		0.14 (0.095, 0.372)		NA (NA, NA)		0.18 (0.049, 0.936)		0.194 (0.019, 2.971)		0.172 (0, 5.649)		0.2 (0.069, 0.744)		0.192 (0.079, 0.549)		2.233 (2.233, 2.233)		0.144 (0.091, 0.275)		0.962 (0.267, 1.656)		0.234 (0.163, 0.304)		1.811 (0.575, 3.047)		0.139 (0.028, 0.251)
PI3K+	TC3	count		42		42		42		42		42		42		42		42		42		42		42		42		42		42		42		42
PI3K+	TC3	time		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)		25 (18, 33)
PI3K+	TC3	n		5 (2, 14)		4 (1, 8)		6 (3, 17)		5 (2, 10)		0 (0, 0)		2 (0, 4)		1 (0, 3)		1 (0, 3)		0 (0, 2)		2 (0, 4)		0 (0, 0)		4 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.35 (0.19, 0.49)		0.36 (0.17, 0.47)		0.36 (0.13, 0.45)		0.38 (0.24, 0.49)		NA (NA, NA)		0.41 (0.3, 0.46)		0.45 (0.31, 0.48)		0.44 (0.34, 0.49)		0.45 (0.37, 0.48)		0.38 (0.3, 0.46)		NA (NA, NA)		0.32 (0.19, 0.44)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.148 (0.098, 0.283)		0.164 (0.098, 0.573)		0.153 (0.099, 0.301)		0.14 (0.098, 0.305)		NA (NA, NA)		0.244 (0.112, 0.588)		0.175 (0.033, 0.694)		0.155 (0.07, 0.322)		0.323 (0.057, 0.701)		0.164 (0.079, 0.525)		0.127 (0.113, 0.321)		0.15 (0.105, 0.446)		0 (0, 0.071)		NA (NA, NA)		NA (NA, NA)		0.058 (0.058, 0.058)
PI3K+	TC4	count		50		50		50		50		50		50		50		50		50		50		50		50		50		50		50		50
PI3K+	TC4	time		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)
PI3K+	TC4	n		5 (3, 14)		3 (1, 7)		6 (3, 10)		4 (2, 8)		0 (0, 0)		2 (0, 5)		1 (0, 3)		1 (0, 3)		0 (0, 3)		1 (0, 4)		0 (0, 0)		3 (1, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.32 (0.19, 0.48)		0.39 (0.23, 0.48)		0.35 (0.18, 0.48)		0.35 (0.17, 0.47)		NA (NA, NA)		0.41 (0.24, 0.49)		0.42 (0.31, 0.49)		0.42 (0.35, 0.48)		0.43 (0.27, 0.49)		0.44 (0.28, 0.48)		NA (NA, NA)		0.36 (0.16, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.5 (0.5, 0.5)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.152 (0.095, 0.291)		0.169 (0.105, 0.344)		0.134 (0.095, 0.222)		0.149 (0.098, 0.381)		0.058 (0.012, 0.149)		0.141 (0.067, 0.611)		0.262 (0.099, 0.984)		0.214 (0.062, 0.978)		0.16 (0, 0.767)		0.161 (0.086, 0.494)		1.048 (1.048, 1.048)		0.193 (0.101, 0.589)		NA (NA, NA)		0.188 (0.148, 0.228)		0.168 (0.034, 0.303)		0.246 (0.212, 1.188)