Setting description

TC5 more effective in the PI3K+ biomarker signature

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.087, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 11.2, median = 8.1
all effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.28, hr = 0.77
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.095, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.3, median = 7.4
AR- & TP53- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.17, hr = 0.85
HRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.097, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.1, median = 7.3
HRD+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.15, hr = 0.86
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.073, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.5, median = 9.7
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.53, hr = 0.64
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.074, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.3, median = 9.5
TEfus+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.51, hr = 0.65
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
PI3K+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
—-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
—+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
—++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
–+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
–++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
–+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
-+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
-+–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
-+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
-+-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
-++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
-++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
-+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
-+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
-++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
+—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
+–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
+–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
+-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
+-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
+-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
+-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
++— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
++–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
++-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
++-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
+++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
+++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33
++++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
++++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 25, median = 18
+++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 2.85, hr = 0.33

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 6 4 5 2 62
AR- & TP53- 18 27 10 14 60
HRD+ 7 10 5 13 17
TP53+ 1 1 3 1 61
TEfus+ 3 0 3 1 34
PI3K+ 0 1 1 2 312
TC1 TC2 TC3 TC4 TC5
all 0.012 0.008 0.010 0.004 0.124
AR- & TP53- 0.036 0.054 0.020 0.028 0.120
HRD+ 0.014 0.020 0.010 0.026 0.034
TP53+ 0.002 0.002 0.006 0.002 0.122
TEfus+ 0.006 0.000 0.006 0.002 0.068
PI3K+ 0.000 0.002 0.002 0.004 0.624
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 10 4 2 0 0
AR- & TP53- 104 79 68 78 2
HRD+ 13 16 38 34 2
TP53+ 55 52 44 41 0
TEfus+ 29 26 18 22 0
PI3K+ 59 56 42 50 0
TC1 TC2 TC3 TC4 TC5
all 0.020 0.008 0.004 0.000 0.000
AR- & TP53- 0.208 0.158 0.136 0.156 0.004
HRD+ 0.026 0.032 0.076 0.068 0.004
TP53+ 0.110 0.104 0.088 0.082 0.000
TEfus+ 0.058 0.052 0.036 0.044 0.000
PI3K+ 0.118 0.112 0.084 0.100 0.000
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 64 41 43 49 36
HRD+ 0 0 0 0 0
TP53+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
PI3K+ 0 0 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.000 0.000
AR- & TP53- 0.128 0.082 0.086 0.098 0.072
HRD+ 0.000 0.000 0.000 0.000 0.000
TP53+ 0.000 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.000 0.000
PI3K+ 0.000 0.000 0.000 0.000 0.000


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.368 0.066 0.086 0.05 0.064 0.156
err_type 0.562 0.066 0.086 0.05 0.064 0.396
pow_sign 0.624 0.000 0.000 0.00 0.000 0.624
pow_type 0.780 0.000 0.000 0.00 0.000 0.780

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 6 4 5 2 62
all futility 0 10 4 2 0 0
all max_n 0 0 0 0 0 0
all n 377 (337, 414) 168 (98, 227) 161 (109, 228) 164 (106, 222) 160 (103, 222) 149 (42, 222)
all n_unique 345 (310, 378) 156 (89, 211) 148 (98, 212) 150 (96, 206) 146 (95, 204) 135 (39, 205)
all time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (9, 36)
all time_stop NA (NA, NA) 5 (4, 14) 6 (5, 15) 7 (6, 21) 8 (6, 9) 7 (6, 10)
all post_p NA (NA, NA) 0.46 (0.07, 0.89) 0.47 (0.08, 0.9) 0.41 (0.08, 0.89) 0.44 (0.08, 0.85) 1 (1, 1)
all rate 0.112 (0.104, 0.121) 0.113 (0.101, 0.129) 0.112 (0.101, 0.127) 0.114 (0.102, 0.128) 0.113 (0.101, 0.128) 0.068 (0.054, 0.081)
AR- & TP53- graduation 0 18 27 10 14 60
AR- & TP53- futility 0 104 79 68 78 2
AR- & TP53- max_n 0 64 41 43 49 36
AR- & TP53- n 222 (188, 258) 97 (30, 151) 82 (32, 145) 93 (39, 146) 82 (36, 148) 78 (23, 140)
AR- & TP53- n_unique 205 (173, 237) 90 (29, 142) 75 (29, 135) 86 (36, 136) 75 (33, 137) 70 (21, 130)
AR- & TP53- time_trial 36 (36, 36) 36 (10, 36) 36 (16, 36) 36 (23, 36) 36 (16, 36) 36 (21, 36)
AR- & TP53- time_stop NA (NA, NA) 12 (5, 25) 16 (9, 32) 18 (10, 31) 16 (10, 28) 12 (9, 26)
AR- & TP53- post_p NA (NA, NA) 0.46 (0.08, 0.88) 0.45 (0.08, 0.88) 0.42 (0.09, 0.85) 0.44 (0.07, 0.87) 0.99 (0.85, 1)
AR- & TP53- rate 0.112 (0.102, 0.124) 0.113 (0.098, 0.141) 0.115 (0.097, 0.139) 0.115 (0.098, 0.137) 0.114 (0.096, 0.143) 0.076 (0.053, 0.096)
HRD+ graduation 0 7 10 5 13 17
HRD+ futility 0 13 16 38 34 2
HRD+ max_n 0 0 0 0 0 0
HRD+ n 59 (48, 72) 26 (11, 42) 27 (14, 40) 33 (20, 48) 31 (19, 49) 22 (4, 37)
HRD+ n_unique 53 (42, 65) 24 (10, 38) 24 (12, 37) 30 (18, 44) 29 (17, 45) 20 (4, 34)
HRD+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
HRD+ time_stop NA (NA, NA) 29 (26, 35) 30 (23, 34) 30 (21, 35) 27 (19, 33) 25 (22, 34)
HRD+ post_p NA (NA, NA) 0.48 (0.13, 0.85) 0.46 (0.13, 0.84) 0.44 (0.11, 0.84) 0.49 (0.1, 0.87) 0.73 (0.31, 0.97)
HRD+ rate 0.112 (0.092, 0.135) 0.112 (0.085, 0.159) 0.115 (0.089, 0.158) 0.115 (0.091, 0.153) 0.114 (0.087, 0.155) 0.092 (0.061, 0.133)
TP53+ graduation 0 1 1 3 1 61
TP53+ futility 0 55 52 44 41 0
TP53+ max_n 0 0 0 0 0 0
TP53+ n 127 (109, 144) 56 (32, 80) 62 (36, 86) 56 (36, 80) 57 (37, 79) 48 (18, 90)
TP53+ n_unique 115 (99, 132) 51 (30, 73) 56 (33, 79) 51 (32, 72) 52 (33, 72) 44 (17, 82)
TP53+ time_trial 36 (36, 36) 36 (31, 36) 36 (34, 36) 36 (36, 36) 36 (36, 36) 36 (22, 36)
TP53+ time_stop NA (NA, NA) 22 (15, 31) 20 (13, 32) 23 (17, 33) 26 (17, 33) 16 (12, 25)
TP53+ post_p NA (NA, NA) 0.41 (0.07, 0.84) 0.49 (0.09, 0.86) 0.42 (0.1, 0.84) 0.44 (0.1, 0.83) 1 (0.98, 1)
TP53+ rate 0.112 (0.098, 0.127) 0.115 (0.096, 0.143) 0.111 (0.094, 0.137) 0.114 (0.095, 0.14) 0.114 (0.095, 0.137) 0.057 (0.042, 0.072)
TEfus+ graduation 0 3 0 3 1 34
TEfus+ futility 0 29 26 18 22 0
TEfus+ max_n 0 0 0 0 0 0
TEfus+ n 118 (103, 135) 54 (32, 76) 61 (40, 82) 57 (37, 76) 57 (37, 77) 47 (18, 81)
TEfus+ n_unique 107 (93, 123) 49 (29, 68) 55 (36, 74) 51 (33, 70) 51 (33, 70) 43 (17, 76)
TEfus+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TEfus+ time_stop NA (NA, NA) 21 (15, 29) 24 (14, 30) 28 (18, 35) 25 (17, 34) 16 (12, 27)
TEfus+ post_p NA (NA, NA) 0.47 (0.1, 0.85) 0.46 (0.11, 0.84) 0.44 (0.09, 0.84) 0.47 (0.1, 0.84) 1 (0.97, 1)
TEfus+ rate 0.113 (0.099, 0.128) 0.113 (0.095, 0.14) 0.112 (0.095, 0.141) 0.114 (0.096, 0.142) 0.113 (0.095, 0.138) 0.059 (0.044, 0.076)
PI3K+ graduation 0 0 1 1 2 312
PI3K+ futility 0 59 56 42 50 0
PI3K+ max_n 0 0 0 0 0 0
PI3K+ n 127 (109, 145) 51 (27, 76) 53 (29, 80) 55 (33, 81) 54 (30, 78) 49 (25, 110)
PI3K+ n_unique 116 (100, 133) 46 (25, 70) 48 (27, 73) 49 (29, 73) 49 (28, 72) 44 (22, 100)
PI3K+ time_trial 36 (36, 36) 36 (31, 36) 36 (33, 36) 36 (36, 36) 36 (35, 36) 25 (11, 36)
PI3K+ time_stop NA (NA, NA) 22 (15, 32) 23 (15, 33) 25 (18, 33) 23 (16, 33) 17 (11, 28)
PI3K+ post_p NA (NA, NA) 0.4 (0.07, 0.84) 0.43 (0.09, 0.84) 0.4 (0.08, 0.83) 0.41 (0.07, 0.84) 1 (1, 1)
PI3K+ rate 0.112 (0.098, 0.127) 0.114 (0.093, 0.146) 0.113 (0.093, 0.143) 0.114 (0.095, 0.138) 0.114 (0.092, 0.142) 0.039 (0.03, 0.048)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 23 31 15 16 118
—– futility 0 111 82 69 78 2
—– max_n 0 64 41 43 49 36
—– n 126 (102, 152) 50 (18, 102) 39 (12, 94) 47 (11, 93) 37 (10, 93) 28 (6, 86)
—– n_unique 117 (94, 142) 48 (18, 98) 36 (11, 89) 44 (10, 88) 36 (9, 89) 26 (6, 82)
—– post_p NA (NA, NA) 0.46 (0.1, 0.9) 0.41 (0.09, 0.88) 0.42 (0.08, 0.87) 0.4 (0.08, 0.85) 0.5 (0.09, 0.88)
—– rate 0.113 (0.1, 0.128) 0.116 (0.097, 0.153) 0.119 (0.095, 0.178) 0.117 (0.094, 0.186) 0.121 (0.096, 0.186) 0.115 (0.088, 0.201)
—-+ graduation 0 23 30 16 16 363
—-+ futility 0 139 121 97 110 2
—-+ max_n 0 63 40 42 48 34
—-+ n 32 (23, 41) 9 (3, 23) 9 (3, 23) 10 (3, 26) 9 (3, 22) 12 (5, 31)
—-+ n_unique 30 (21, 38) 8 (3, 21) 8 (2, 21) 9 (3, 23) 8 (2, 20) 11 (4, 28)
—-+ post_p NA (NA, NA) 0.41 (0.14, 0.8) 0.41 (0.16, 0.76) 0.39 (0.14, 0.75) 0.39 (0.16, 0.78) 0.99 (0.83, 1)
—-+ rate 0.114 (0.087, 0.151) 0.121 (0.081, 0.279) 0.123 (0.078, 0.301) 0.122 (0.084, 0.258) 0.123 (0.081, 0.274) 0.04 (0.024, 0.065)
—+- graduation 0 24 31 17 15 141
—+- futility 0 122 93 78 89 2
—+- max_n 0 64 41 42 49 36
—+- n 5 (2, 8) 3 (1, 6) 3 (1, 6) 2 (0, 6) 2 (0, 6) 2 (0, 5)
—+- n_unique 4 (1, 8) 2 (1, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5)
—+- post_p NA (NA, NA) 0.48 (0.28, 0.76) 0.47 (0.27, 0.72) 0.48 (0.31, 0.76) 0.45 (0.27, 0.72) 0.48 (0.28, 0.74)
—+- rate 0.114 (0.059, 0.232) 0.128 (0.052, 0.381) 0.135 (0.054, 0.466) 0.122 (0.05, 0.404) 0.138 (0.055, 0.53) 0.123 (0.038, 0.428)
—++ graduation 0 24 30 18 16 363
—++ futility 0 143 129 104 118 2
—++ max_n 0 63 40 41 48 34
—++ n 14 (9, 20) 5 (1, 12) 5 (1, 12) 5 (2, 12) 5 (2, 12) 5 (2, 14)
—++ n_unique 13 (8, 19) 4 (1, 11) 4 (1, 10) 5 (1, 11) 5 (1, 11) 5 (2, 13)
—++ post_p NA (NA, NA) 0.41 (0.19, 0.75) 0.41 (0.2, 0.74) 0.42 (0.2, 0.75) 0.42 (0.2, 0.75) 0.9 (0.56, 0.99)
—++ rate 0.115 (0.075, 0.173) 0.128 (0.068, 0.311) 0.129 (0.071, 0.317) 0.122 (0.064, 0.325) 0.128 (0.067, 0.357) 0.043 (0.02, 0.093)
–+– graduation 0 7 5 8 3 119
–+– futility 0 64 55 46 41 0
–+– max_n 0 0 0 0 0 0
–+– n 26 (19, 34) 11 (4, 24) 11 (4, 24) 10 (4, 22) 11 (4, 23) 8 (2, 19)
–+– n_unique 24 (16, 32) 10 (3, 22) 10 (4, 23) 9 (3, 21) 10 (3, 21) 7 (2, 18)
–+– post_p NA (NA, NA) 0.43 (0.16, 0.84) 0.48 (0.18, 0.86) 0.4 (0.16, 0.85) 0.45 (0.17, 0.82) 0.47 (0.19, 0.83)
–+– rate 0.111 (0.084, 0.151) 0.124 (0.085, 0.29) 0.116 (0.081, 0.24) 0.129 (0.082, 0.259) 0.123 (0.083, 0.257) 0.125 (0.077, 0.282)
–+-+ graduation 0 7 6 9 4 373
–+-+ futility 0 102 98 74 75 0
–+-+ max_n 0 0 0 0 0 0
–+-+ n 26 (20, 35) 7 (3, 21) 8 (3, 21) 9 (3, 22) 9 (3, 22) 10 (4, 27)
–+-+ n_unique 24 (18, 33) 7 (3, 19) 7 (3, 19) 8 (3, 20) 8 (3, 19) 9 (3, 25)
–+-+ post_p NA (NA, NA) 0.37 (0.15, 0.72) 0.39 (0.14, 0.77) 0.4 (0.14, 0.78) 0.37 (0.16, 0.77) 0.98 (0.8, 1)
–+-+ rate 0.112 (0.086, 0.153) 0.131 (0.081, 0.261) 0.123 (0.077, 0.269) 0.122 (0.081, 0.286) 0.123 (0.077, 0.25) 0.038 (0.021, 0.069)
–++- graduation 0 10 5 10 4 135
–++- futility 0 79 71 55 55 0
–++- max_n 0 0 0 0 0 0
–++- n 7 (3, 11) 3 (1, 7) 4 (1, 9) 3 (1, 7) 3 (1, 7) 2 (0, 6)
–++- n_unique 7 (3, 10) 3 (1, 7) 4 (1, 8) 3 (1, 6) 3 (1, 7) 2 (0, 6)
–++- post_p NA (NA, NA) 0.45 (0.25, 0.8) 0.48 (0.25, 0.81) 0.49 (0.27, 0.76) 0.47 (0.25, 0.78) 0.47 (0.28, 0.75)
–++- rate 0.119 (0.068, 0.221) 0.136 (0.057, 0.514) 0.133 (0.062, 0.353) 0.13 (0.054, 0.359) 0.132 (0.059, 0.446) 0.134 (0.06, 0.467)
–+++ graduation 0 10 6 11 5 373
–+++ futility 0 110 108 82 88 0
–+++ max_n 0 0 0 0 0 0
–+++ n 20 (14, 27) 7 (3, 17) 8 (3, 18) 7 (3, 16) 7 (2, 16) 8 (3, 20)
–+++ n_unique 18 (13, 25) 6 (2, 15) 7 (2, 17) 7 (2, 15) 6 (2, 15) 7 (2, 18)
–+++ post_p NA (NA, NA) 0.37 (0.15, 0.75) 0.41 (0.17, 0.74) 0.43 (0.18, 0.77) 0.4 (0.17, 0.8) 0.96 (0.64, 1)
–+++ rate 0.114 (0.081, 0.159) 0.128 (0.077, 0.317) 0.125 (0.077, 0.264) 0.124 (0.07, 0.278) 0.125 (0.069, 0.334) 0.04 (0.019, 0.082)
-+— graduation 0 29 38 20 28 132
-+— futility 0 121 95 95 106 4
-+— max_n 0 64 39 41 49 36
-+— n 26 (18, 35) 9 (1, 23) 9 (2, 20) 12 (4, 25) 10 (4, 25) 7 (1, 20)
-+— n_unique 24 (16, 31) 8 (1, 21) 8 (2, 18) 11 (4, 23) 10 (4, 23) 6 (1, 18)
-+— post_p NA (NA, NA) 0.45 (0.17, 0.85) 0.44 (0.19, 0.8) 0.46 (0.15, 0.84) 0.46 (0.15, 0.84) 0.45 (0.16, 0.84)
-+— rate 0.112 (0.083, 0.146) 0.12 (0.075, 0.268) 0.125 (0.081, 0.272) 0.118 (0.081, 0.257) 0.119 (0.081, 0.246) 0.123 (0.076, 0.309)
-+–+ graduation 0 29 37 21 28 363
-+–+ futility 0 149 132 121 135 4
-+–+ max_n 0 63 38 40 48 34
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) 0.51 (0.47, 0.55) 0.55 (0.53, 0.58) 0.5 (0.5, 0.5) 0.59 (0.59, 0.59) 0.48 (0.48, 0.48)
-+–+ rate 0.121 (0, 0.636) 0.16 (0, 0.573) 0.104 (0, 3.802) 0.149 (0.082, 0.598) 0.084 (0, 0.292) 0.041 (0, 0.453)
-+-+- graduation 0 30 38 22 26 155
-+-+- futility 0 132 105 103 115 4
-+-+- max_n 0 64 39 40 49 36
-+-+- n 12 (7, 18) 4 (0, 10) 5 (1, 11) 6 (2, 13) 6 (2, 12) 4 (0, 10)
-+-+- n_unique 11 (6, 17) 4 (0, 9) 4 (1, 10) 5 (2, 12) 5 (2, 11) 4 (0, 10)
-+-+- post_p NA (NA, NA) 0.45 (0.22, 0.79) 0.46 (0.21, 0.79) 0.45 (0.21, 0.8) 0.48 (0.22, 0.83) 0.49 (0.24, 0.8)
-+-+- rate 0.114 (0.073, 0.176) 0.129 (0.068, 0.382) 0.131 (0.07, 0.377) 0.13 (0.073, 0.289) 0.12 (0.07, 0.275) 0.123 (0.06, 0.286)
-+-++ graduation 0 30 37 23 27 363
-+-++ futility 0 153 139 127 141 4
-+-++ max_n 0 63 38 39 48 34
-+-++ n 5 (2, 9) 2 (0, 5) 2 (0, 5) 3 (1, 6) 3 (1, 6) 1 (0, 4)
-+-++ n_unique 4 (2, 8) 2 (0, 5) 2 (0, 5) 3 (0, 5) 3 (1, 6) 1 (0, 4)
-+-++ post_p NA (NA, NA) 0.46 (0.28, 0.72) 0.47 (0.29, 0.72) 0.42 (0.24, 0.68) 0.44 (0.26, 0.71) 0.7 (0.43, 0.91)
-+-++ rate 0.115 (0.059, 0.244) 0.135 (0.042, 0.431) 0.121 (0.042, 0.41) 0.147 (0.059, 0.484) 0.135 (0.059, 0.453) 0.04 (0, 0.16)
-++– graduation 0 14 14 12 16 133
-++– futility 0 76 70 77 72 2
-++– max_n 0 0 0 0 0 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.54 (0.54, 0.54) 0.54 (0.54, 0.54) 0.53 (0.48, 0.57) 0.49 (0.48, 0.5) NA (NA, NA)
-++– rate 0.161 (0.006, 1.028) 0.146 (0, 1.258) 0.104 (0, 0.68) 0.091 (0, 0.996) 0.193 (0, 0.596) 0.128 (0, 2.062)
-++-+ graduation 0 14 15 13 17 374
-++-+ futility 0 113 111 103 101 2
-++-+ max_n 0 0 0 0 0 0
-++-+ n 2 (0, 5) 1 (0, 4) 1 (0, 3) 2 (0, 4) 2 (0, 4) 1 (0, 2)
-++-+ n_unique 2 (0, 5) 1 (0, 3) 1 (0, 3) 2 (0, 4) 1 (0, 4) 1 (0, 2)
-++-+ post_p NA (NA, NA) 0.47 (0.33, 0.68) 0.48 (0.32, 0.68) 0.46 (0.32, 0.67) 0.45 (0.31, 0.65) 0.6 (0.41, 0.79)
-++-+ rate 0.118 (0.038, 0.359) 0.132 (0, 0.658) 0.133 (0, 0.589) 0.136 (0.047, 0.415) 0.146 (0.043, 0.604) 0.05 (0, 0.232)
-+++- graduation 0 17 14 14 16 149
-+++- futility 0 91 84 85 83 2
-+++- max_n 0 0 0 0 0 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.46 (0.45, 0.52) 0.59 (0.59, 0.59) 0.48 (0.46, 0.5) 0.5 (0.47, 0.53) 0.5 (0.48, 0.52)
-+++- rate 0.114 (0, 0.536) 0.179 (0, 1.396) 0.133 (0, 1.547) 0.373 (0.119, 2.476) 0.152 (0.057, 1.567) 0.488 (0.117, 1.902)
-++++ graduation 0 17 15 15 17 374
-++++ futility 0 121 120 110 111 2
-++++ max_n 0 0 0 0 0 0
-++++ n 3 (1, 6) 1 (0, 4) 1 (0, 4) 2 (0, 4) 2 (0, 4) 1 (0, 3)
-++++ n_unique 3 (0, 5) 1 (0, 3) 1 (0, 3) 2 (0, 4) 2 (0, 4) 0 (0, 3)
-++++ post_p NA (NA, NA) 0.46 (0.3, 0.67) 0.47 (0.33, 0.68) 0.45 (0.31, 0.66) 0.46 (0.31, 0.66) 0.63 (0.39, 0.83)
-++++ rate 0.124 (0.047, 0.361) 0.138 (0.037, 0.48) 0.134 (0.027, 0.718) 0.136 (0.045, 0.454) 0.131 (0.038, 0.463) 0.043 (0, 0.225)
+—- graduation 0 6 4 5 2 62
+—- futility 0 10 4 2 0 0
+—- max_n 0 0 0 0 0 0
+—- n 5 (2, 8) 2 (1, 5) 3 (1, 6) 2 (1, 5) 2 (1, 5) 2 (0, 5)
+—- n_unique 4 (1, 7) 2 (0, 5) 3 (1, 6) 2 (1, 5) 2 (0, 5) 2 (0, 4)
+—- post_p NA (NA, NA) 0.48 (0.28, 0.74) 0.46 (0.26, 0.74) 0.48 (0.31, 0.74) 0.48 (0.28, 0.74) 0.48 (0.29, 0.76)
+—- rate 0.124 (0.058, 0.292) 0.131 (0.048, 0.467) 0.138 (0.06, 0.371) 0.138 (0.05, 0.463) 0.138 (0.04, 0.501) 0.135 (0.049, 0.397)
+—+ graduation 0 6 5 6 4 362
+—+ futility 0 67 60 43 50 0
+—+ max_n 0 0 0 0 0 0
+—+ n 2 (0, 4) 1 (0, 3) 1 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 2)
+—+ n_unique 2 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 2)
+—+ post_p NA (NA, NA) 0.47 (0.35, 0.64) 0.47 (0.36, 0.67) 0.48 (0.35, 0.64) 0.48 (0.35, 0.64) 0.58 (0.43, 0.75)
+—+ rate 0.121 (0.021, 0.41) 0.147 (0, 0.737) 0.137 (0.029, 0.569) 0.124 (0, 0.492) 0.128 (0, 0.697) 0.051 (0, 0.189)
+–+- graduation 0 9 4 8 3 92
+–+- futility 0 37 28 19 22 0
+–+- max_n 0 0 0 0 0 0
+–+- n 8 (4, 11) 4 (1, 8) 4 (2, 9) 3 (1, 7) 3 (1, 7) 3 (0, 7)
+–+- n_unique 7 (4, 11) 3 (1, 7) 4 (1, 8) 3 (1, 7) 3 (1, 6) 3 (0, 6)
+–+- post_p NA (NA, NA) 0.47 (0.24, 0.79) 0.47 (0.22, 0.79) 0.47 (0.25, 0.78) 0.44 (0.25, 0.76) 0.45 (0.26, 0.78)
+–+- rate 0.113 (0.068, 0.212) 0.135 (0.057, 0.378) 0.129 (0.065, 0.365) 0.133 (0.05, 0.432) 0.14 (0.057, 0.437) 0.135 (0.057, 0.424)
+–++ graduation 0 9 5 9 5 362
+–++ futility 0 78 76 55 67 0
+–++ max_n 0 0 0 0 0 0
+–++ n 3 (1, 7) 2 (0, 4) 2 (1, 5) 2 (0, 4) 2 (0, 5) 1 (0, 4)
+–++ n_unique 3 (1, 6) 2 (0, 4) 2 (0, 5) 2 (0, 4) 2 (0, 4) 1 (0, 4)
+–++ post_p NA (NA, NA) 0.46 (0.29, 0.67) 0.45 (0.29, 0.67) 0.46 (0.28, 0.68) 0.46 (0.32, 0.71) 0.66 (0.45, 0.87)
+–++ rate 0.125 (0.044, 0.34) 0.14 (0.038, 0.469) 0.126 (0.049, 0.457) 0.13 (0.029, 0.551) 0.126 (0.036, 0.437) 0.04 (0, 0.153)
+-+– graduation 0 7 5 8 3 119
+-+– futility 0 64 55 46 41 0
+-+– max_n 0 0 0 0 0 0
+-+– n 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 2)
+-+– post_p NA (NA, NA) 0.47 (0.36, 0.63) 0.49 (0.36, 0.64) 0.48 (0.38, 0.66) 0.48 (0.37, 0.63) 0.48 (0.38, 0.66)
+-+– rate 0.123 (0, 0.485) 0.139 (0, 0.634) 0.132 (0, 0.61) 0.129 (0, 0.701) 0.142 (0, 0.916) 0.135 (0, 0.608)
+-+-+ graduation 0 7 6 9 4 373
+-+-+ futility 0 102 98 74 75 0
+-+-+ max_n 0 0 0 0 0 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) NA (NA, NA) 0.47 (0.44, 0.51) 0.51 (0.46, 0.56) NA (NA, NA) NA (NA, NA)
+-+-+ rate 0.087 (0, 0.932) 0.225 (0.139, 1.565) 0.145 (0.008, 1.631) 0.162 (0, 0.586) 0.027 (0, 0.405) 0.057 (0, 0.336)
+-++- graduation 0 10 5 10 4 135
+-++- futility 0 79 71 55 55 0
+-++- max_n 0 0 0 0 0 0
+-++- n 21 (15, 28) 8 (3, 18) 11 (4, 22) 8 (3, 17) 9 (3, 19) 5 (1, 16)
+-++- n_unique 19 (13, 26) 8 (3, 16) 10 (4, 20) 7 (2, 16) 8 (3, 18) 5 (1, 15)
+-++- post_p NA (NA, NA) 0.48 (0.2, 0.83) 0.47 (0.17, 0.87) 0.44 (0.18, 0.82) 0.45 (0.18, 0.82) 0.49 (0.2, 0.84)
+-++- rate 0.115 (0.082, 0.158) 0.122 (0.077, 0.274) 0.118 (0.079, 0.227) 0.126 (0.077, 0.307) 0.123 (0.079, 0.306) 0.121 (0.069, 0.3)
+-+++ graduation 0 10 6 11 5 373
+-+++ futility 0 110 108 82 88 0
+-+++ max_n 0 0 0 0 0 0
+-+++ n 17 (11, 23) 6 (2, 15) 7 (3, 15) 7 (3, 14) 6 (2, 15) 6 (2, 16)
+-+++ n_unique 15 (10, 21) 5 (2, 13) 6 (2, 13) 6 (2, 13) 5 (2, 13) 5 (2, 14)
+-+++ post_p NA (NA, NA) 0.43 (0.19, 0.76) 0.4 (0.19, 0.76) 0.4 (0.18, 0.77) 0.39 (0.18, 0.75) 0.94 (0.61, 1)
+-+++ rate 0.113 (0.078, 0.168) 0.12 (0.073, 0.334) 0.122 (0.074, 0.27) 0.126 (0.074, 0.29) 0.125 (0.077, 0.313) 0.04 (0.019, 0.085)
++— graduation 0 13 14 10 15 79
++— futility 0 23 20 40 34 2
++— max_n 0 0 0 0 0 0
++— n 8 (4, 13) 4 (1, 8) 4 (1, 8) 4 (2, 9) 4 (2, 8) 3 (0, 7)
++— n_unique 7 (3, 12) 3 (1, 7) 4 (1, 7) 4 (2, 8) 4 (2, 8) 3 (0, 7)
++— post_p NA (NA, NA) 0.49 (0.27, 0.78) 0.47 (0.24, 0.78) 0.47 (0.23, 0.74) 0.48 (0.25, 0.8) 0.5 (0.29, 0.78)
++— rate 0.118 (0.065, 0.221) 0.124 (0.054, 0.328) 0.128 (0.058, 0.374) 0.123 (0.066, 0.332) 0.124 (0.063, 0.332) 0.122 (0.056, 0.31)
++–+ graduation 0 13 15 11 17 364
++–+ futility 0 79 73 78 79 2
++–+ max_n 0 0 0 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) 0.53 (0.53, 0.53) 0.45 (0.45, 0.45) NA (NA, NA) 0.51 (0.48, 0.56) NA (NA, NA)
++–+ rate 0.179 (0.042, 0.598) 0.187 (0, 0.691) 0.205 (0, 1.124) 0.091 (0, 0.613) 0.056 (0, 0.333) 0.104 (0.072, 0.148)
++-+- graduation 0 16 14 13 15 109
++-+- futility 0 50 42 54 52 2
++-+- max_n 0 0 0 0 0 0
++-+- n 1 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 2)
++-+- n_unique 1 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- post_p NA (NA, NA) 0.48 (0.36, 0.61) 0.51 (0.41, 0.65) 0.49 (0.39, 0.61) 0.48 (0.37, 0.61) 0.5 (0.4, 0.6)
++-+- rate 0.128 (0, 0.567) 0.129 (0, 0.535) 0.119 (0, 0.62) 0.145 (0, 0.65) 0.154 (0, 0.732) 0.131 (0, 0.683)
++-++ graduation 0 16 15 14 17 364
++-++ futility 0 90 88 87 92 2
++-++ max_n 0 0 0 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) 0.53 (0.48, 0.59) 0.47 (0.46, 0.5) NA (NA, NA) 0.44 (0.44, 0.44) 0.47 (0.47, 0.47)
++-++ rate 0.11 (0, 0.834) 0.295 (0.134, 0.924) 0.22 (0.017, 1.26) 0.156 (0, 2.448) 0.129 (0, 0.745) 0.079 (0, 0.318)
+++– graduation 0 14 14 12 16 133
+++– futility 0 76 70 77 72 2
+++– max_n 0 0 0 0 0 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.47 (0.42, 0.6) 0.52 (0.45, 0.61) 0.49 (0.42, 0.53) 0.5 (0.44, 0.58) 0.53 (0.45, 0.62)
+++– rate 0.139 (0, 0.875) 0.123 (0, 0.633) 0.154 (0, 0.702) 0.115 (0, 1.088) 0.152 (0, 0.99) 0.156 (0, 0.669)
+++-+ graduation 0 14 15 13 17 374
+++-+ futility 0 113 111 103 101 2
+++-+ max_n 0 0 0 0 0 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) NA (NA, NA) 0.56 (0.54, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+++-+ rate 0.246 (0, 1.846) 0.37 (0, 1.335) 0.126 (0, 0.547) 0.106 (0, 0.514) 0.228 (0, 1.559) 0.075 (0, 0.172)
++++- graduation 0 17 14 14 16 149
++++- futility 0 91 84 85 83 2
++++- max_n 0 0 0 0 0 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) 0.52 (0.49, 0.52) 0.49 (0.44, 0.54) 0.49 (0.49, 0.49)
++++- rate 0.133 (0, 0.562) 0.126 (0.044, 1.145) 0.129 (0, 1.16) 0.131 (0, 0.332) 0.154 (0, 0.73) 0.061 (0, 0.772)
+++++ graduation 0 17 15 15 17 374
+++++ futility 0 121 120 110 111 2
+++++ max_n 0 0 0 0 0 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) 0.52 (0.51, 0.54) 0.51 (0.51, 0.51) 0.5 (0.44, 0.52) 0.62 (0.56, 0.64) NA (NA, NA)
+++++ rate 0.147 (0.067, 1.59) 0.133 (0, 0.354) 0.159 (0, 1.542) 0.096 (0.036, 0.405) 0.165 (0, 0.456) 0.039 (0, 0.082)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 6 4 5 2 62
all time_stop 6 (4, 6) 6 (5, 7) 7 (6, 7) 8 (6, 9) 7 (6, 10)
all n_trt 34 (28, 46) 32 (28, 40) 26 (25, 29) 38 (31, 46) 31 (26, 44)
all n_control 60 (50, 68) 59 (54, 62) 62 (52, 80) 69 (64, 74) 64 (49, 98)
all post_p 0.94 (0.89, 0.96) 0.94 (0.9, 0.96) 0.91 (0.86, 0.95) 0.91 (0.89, 0.93) 0.98 (0.95, 1)
all order 1 (1, 1) 1 (1, 1) 1 (1, 2) 1.5 (1.1, 1.9) 1 (1, 1)
AR- & TP53- count 18 27 10 14 60
AR- & TP53- time_stop 7 (5, 12) 10 (8, 13) 10 (9, 13) 11 (9, 15) 12 (9, 25)
AR- & TP53- n_trt 35 (27, 47) 28 (25, 45) 28 (25, 49) 30 (25, 42) 30 (26, 65)
AR- & TP53- n_control 43 (33, 61) 51 (38, 70) 51 (45, 82) 58 (49, 80) 64 (46, 139)
AR- & TP53- post_p 0.9 (0.87, 0.97) 0.93 (0.86, 0.97) 0.92 (0.9, 0.98) 0.95 (0.89, 0.99) 0.99 (0.93, 1)
AR- & TP53- order 1 (1, 2) 1 (1, 2) 1 (1, 1.1) 1 (1, 1.7) 1 (1, 2.1)
HRD+ count 7 10 5 13 17
HRD+ time_stop 29 (25, 29) 28 (22, 33) 22 (19, 29) 23 (17, 29) 25 (22, 32)
HRD+ n_trt 27 (26, 43) 26 (25, 34) 29 (26, 43) 28 (25, 38) 26 (25, 30)
HRD+ n_control 41 (33, 49) 48 (33, 57) 25 (22, 38) 30 (20, 46) 41 (28, 63)
HRD+ post_p 0.91 (0.89, 0.96) 0.91 (0.86, 0.96) 0.9 (0.85, 0.96) 0.94 (0.87, 0.99) 0.94 (0.91, 0.99)
HRD+ order 3 (2, 3) 3 (1, 4) 1 (1, 2) 2 (1.2, 2) 2 (1, 3)
TP53+ count 1 1 3 1 61
TP53+ time_stop 19 (19, 19) 9 (9, 9) 18 (16, 20) 10 (10, 10) 16 (12, 25)
TP53+ n_trt 42 (42, 42) 31 (31, 31) 26 (25, 27) 25 (25, 25) 31 (25, 45)
TP53+ n_control 65 (65, 65) 23 (23, 23) 55 (53, 56) 27 (27, 27) 48 (33, 82)
TP53+ post_p 0.97 (0.97, 0.97) 0.97 (0.97, 0.97) 0.94 (0.88, 0.95) 0.94 (0.94, 0.94) 1 (0.97, 1)
TP53+ order 2 (2, 2) 1 (1, 1) 3 (2.2, 3) 1 (1, 1) 1 (1, 2)
TEfus+ count 3 3 1 34
TEfus+ time_stop 15 (12, 17) 19 (17, 21) 15 (15, 15) 16 (12, 27)
TEfus+ n_trt 26 (25, 27) 26 (25, 28) 25 (25, 25) 27 (25, 39)
TEfus+ n_control 39 (29, 48) 42 (40, 60) 33 (33, 33) 46 (32, 87)
TEfus+ post_p 0.9 (0.89, 0.92) 0.98 (0.94, 0.99) 0.93 (0.93, 0.93) 0.99 (0.97, 1)
TEfus+ order 2 (2, 2) 1 (1, 1.8) 1 (1, 1) 2 (1, 3)
PI3K+ count 1 1 2 312
PI3K+ time_stop 17 (17, 17) 16 (16, 16) 17 (14, 20) 17 (11, 28)
PI3K+ n_trt 26 (26, 26) 31 (31, 31) 30 (27, 33) 40 (26, 77)
PI3K+ n_control 53 (53, 53) 50 (50, 50) 52 (46, 58) 51 (27, 90)
PI3K+ post_p 0.89 (0.89, 0.89) 0.97 (0.97, 0.97) 0.93 (0.9, 0.96) 1 (0.99, 1)
PI3K+ order 2 (2, 2) 2 (2, 2) 2.5 (2.1, 2.9) 1 (1, 2)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 10 4 2
all time_stop 4 (4, 22) 12 (7, 17) 23 (13, 33)
all n_trt 32 (25, 81) 46 (34, 75) 57 (35, 79)
all n_control 48 (38, 203) 110 (67, 153) 230 (125, 334)
all post_p 0.13 (0.01, 0.23) 0.04 (0.02, 0.21) 0.03 (0.01, 0.06)
all order 1 (1, 4) 1 (1, 2.4) 3 (2.2, 3.8)
AR- & TP53- count 104 79 68 78 2
AR- & TP53- time_stop 13 (5, 25) 20 (12, 33) 22 (12, 31) 16 (11, 29) 26 (18, 33)
AR- & TP53- n_trt 38 (25, 79) 39 (25, 97) 40 (25, 88) 38 (26, 76) 44 (30, 58)
AR- & TP53- n_control 72 (30, 154) 122 (64, 202) 117 (54, 203) 85 (55, 168) 135 (97, 173)
AR- & TP53- post_p 0.12 (0.02, 0.27) 0.11 (0.02, 0.22) 0.08 (0.02, 0.21) 0.1 (0.03, 0.2) 0.16 (0.14, 0.18)
AR- & TP53- order 1 (1, 2) 2 (1, 4) 1 (1, 3) 1 (1, 3) 3 (3, 3)
HRD+ count 13 16 38 34 2
HRD+ time_stop 29 (27, 36) 32 (26, 34) 30 (22, 35) 28 (21, 34) 32 (28, 35)
HRD+ n_trt 28 (25, 31) 27 (25, 36) 28 (25, 37) 28 (25, 34) 26 (25, 26)
HRD+ n_control 49 (41, 71) 52 (33, 66) 44 (30, 59) 44 (30, 59) 42 (32, 52)
HRD+ post_p 0.1 (0.01, 0.23) 0.16 (0.07, 0.26) 0.13 (0.07, 0.23) 0.09 (0.01, 0.24) 0.12 (0.08, 0.15)
HRD+ order 2 (1, 2.8) 2.5 (1, 5) 2 (1, 4) 2 (1, 4) 3 (2.2, 3.8)
TP53+ count 55 52 44 41
TP53+ time_stop 22 (15, 31) 20 (13, 32) 24 (17, 34) 27 (18, 33)
TP53+ n_trt 32 (26, 48) 32 (25, 51) 35 (25, 48) 35 (26, 51)
TP53+ n_control 68 (41, 104) 64 (37, 105) 76 (50, 110) 97 (53, 115)
TP53+ post_p 0.07 (0.02, 0.22) 0.08 (0.02, 0.19) 0.07 (0.02, 0.2) 0.11 (0.02, 0.2)
TP53+ order 2 (1, 4) 1 (1, 4) 2 (1, 4.7) 2 (1, 4)
TEfus+ count 29 26 18 22
TEfus+ time_stop 22 (16, 29) 24 (14, 30) 30 (18, 35) 26 (18, 34)
TEfus+ n_trt 31 (25, 42) 33 (26, 46) 34 (26, 49) 34 (27, 48)
TEfus+ n_control 66 (42, 98) 68 (31, 96) 94 (42, 130) 75 (43, 113)
TEfus+ post_p 0.04 (0.01, 0.1) 0.06 (0.02, 0.21) 0.05 (0.01, 0.22) 0.1 (0.01, 0.18)
TEfus+ order 3 (2, 4.2) 2 (1, 3) 3 (1, 5.3) 2 (1, 3)
PI3K+ count 59 56 42 50
PI3K+ time_stop 22 (15, 32) 23 (15, 33) 25 (18, 33) 24 (16, 33)
PI3K+ n_trt 28 (25, 50) 32 (26, 49) 32 (26, 53) 30 (25, 47)
PI3K+ n_control 68 (41, 109) 72 (42, 118) 79 (51, 112) 72 (48, 119)
PI3K+ post_p 0.07 (0.01, 0.24) 0.1 (0.03, 0.2) 0.06 (0.01, 0.22) 0.11 (0.01, 0.25)
PI3K+ order 2 (1, 4.2) 2 (1, 4) 2 (1, 4) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
all TC1 time 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6) 6 (4, 6)
all TC1 n 16 (14, 28) 4 (2, 6) 0 (0, 1) 1 (0, 3) 2 (0, 4) 2 (0, 4) 0 (0, 2) 1 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 3) 1 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.62 (0.55, 0.86) 0.51 (0.5, 0.65) 0.51 (0.51, 0.51) 0.54 (0.51, 0.56) 0.56 (0.55, 0.58) 0.52 (0.51, 0.75) 0.55 (0.52, 0.58) 0.54 (0.52, 0.57) 0.55 (0.52, 0.58) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.53, 0.57) 0.52 (0.51, 0.53) NA (NA, NA) 0.57 (0.51, 0.62) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) 0.56 (0.51, 0.64) 0.56 (0.51, 0.58) 0.55 (0.55, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.074 (0.028, 0.09) 0.033 (0, 0.104) 0 (0, 0) 0 (0, 0.104) 0 (0, 0.04) 0 (0, 0) 0 (0, 0) 0 (0, 0.073) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0.098) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0.107) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC2 time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
all TC2 n 12 (9, 16) 0 (0, 2) 0 (0, 1) 0 (0, 1) 2 (2, 4) 1 (1, 2) 1 (1, 2) 3 (1, 4) 0 (0, 3) 0 (0, 0) 1 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 2 (0, 2) 0 (0, 1) 1 (0, 3) 0 (0, 1) 0 (0, 1) 0 (0, 0) 4 (2, 5) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.76 (0.6, 0.85) 0.53 (0.52, 0.53) 0.55 (0.53, 0.57) 0.51 (0.51, 0.51) 0.56 (0.52, 0.58) 0.55 (0.54, 0.56) 0.53 (0.51, 0.59) 0.54 (0.53, 0.57) 0.51 (0.51, 0.52) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.51, 0.53) NA (NA, NA) 0.62 (0.62, 0.63) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.51, 0.53) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.072 (0.04, 0.079) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.067 (0.013, 0.121) 0.048 (0.01, 0.087) NA (NA, NA) 0 (0, 1.416) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0.075) 0 (0, 0) 0.067 (0.013, 0.121) 0.142 (0.028, 0.255) 0 (0, 0) NA (NA, NA) 0 (0, 0.036) 0.205 (0.205, 0.205) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC3 time 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7) 7 (6, 7)
all TC3 n 6 (2, 14) 1 (0, 2) 0 (0, 1) 1 (0, 2) 2 (1, 4) 1 (1, 2) 0 (0, 0) 1 (0, 1) 2 (2, 6) 0 (0, 0) 2 (0, 3) 0 (0, 1) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 2) 1 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 2 (0, 4) 1 (0, 3) 1 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.57 (0.52, 0.78) 0.53 (0.53, 0.53) NA (NA, NA) 0.53 (0.51, 0.54) 0.54 (0.52, 0.58) 0.52 (0.52, 0.6) NA (NA, NA) 0.53 (0.52, 0.54) 0.58 (0.53, 0.65) NA (NA, NA) 0.54 (0.51, 0.56) 0.53 (0.53, 0.53) NA (NA, NA) 0.54 (0.51, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.52, 0.65) 0.53 (0.52, 0.68) 0.53 (0.53, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0 (0, 0.102) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.083) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.103) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.295 (0.059, 0.532) 0.394 (0.079, 0.829) 0 (0, 0) NA (NA, NA) 1.097 (1.097, 1.097) 0 (0, 0) NA (NA, NA) 0 (0, 0.055) 0 (0, 0) 0 (0, 0.046) NA (NA, NA) NA (NA, NA) 0.24 (0.24, 0.24) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC4 time 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9) 8 (6, 9)
all TC4 n 12 (6, 19) 2 (1, 3) 0 (0, 0) 0 (0, 0) 4 (3, 5) 2 (2, 2) 0 (0, 1) 0 (0, 0) 6 (5, 7) 0 (0, 0) 3 (2, 4) 1 (0, 2) 0 (0, 0) 2 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 3) 1 (1, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.68 (0.59, 0.76) 0.58 (0.54, 0.63) NA (NA, NA) NA (NA, NA) 0.53 (0.52, 0.54) 0.55 (0.55, 0.55) 0.56 (0.56, 0.56) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) 0.58 (0.58, 0.58) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.58 (0.57, 0.58) 0.55 (0.54, 0.55) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.119 (0.075, 0.163) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.062 (0.012, 0.112) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.078 (0.016, 0.14) NA (NA, NA) 0.045 (0.009, 0.08) 0.387 (0.387, 0.387) NA (NA, NA) 0.131 (0.131, 0.131) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62 62
all TC5 time 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10) 7 (6, 10)
all TC5 n 6 (2, 13) 6 (3, 8) 0 (0, 1) 3 (1, 6) 1 (0, 5) 4 (1, 7) 0 (0, 1) 3 (1, 6) 1 (0, 3) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 2) 0 (0, 1) 1 (0, 2) 0 (0, 1) 0 (0, 0) 1 (0, 2) 3 (1, 5) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.6 (0.53, 0.76) 0.62 (0.53, 0.73) 0.54 (0.54, 0.63) 0.57 (0.51, 0.72) 0.55 (0.52, 0.68) 0.6 (0.53, 0.78) 0.55 (0.52, 0.58) 0.56 (0.51, 0.69) 0.55 (0.52, 0.65) NA (NA, NA) 0.54 (0.51, 0.63) 0.52 (0.51, 0.62) NA (NA, NA) 0.52 (0.51, 0.58) NA (NA, NA) 0.55 (0.51, 0.63) 0.57 (0.53, 0.76) 0.53 (0.51, 0.55) 0.57 (0.52, 0.65) 0.54 (0.51, 0.59) 0.54 (0.52, 0.56) NA (NA, NA) 0.55 (0.52, 0.61) 0.56 (0.52, 0.69) 0.56 (0.51, 0.6) NA (NA, NA) 0.55 (0.51, 0.58) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.055 (0, 0.102) 0 (0, 0.079) 0 (0, 1.059) 0 (0, 0.096) 0 (0, 0.096) 0 (0, 0.089) 0 (0, 0.096) 0 (0, 0.075) 0 (0, 0.083) NA (NA, NA) 0 (0, 0.099) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.052) 0 (0, 0.019) 0 (0, 0.206) 0 (0, 0) 0 (0, 0.811) 0 (0, 0) 0 (0, 0) 0 (0, 0.074) 0 (0, 0.12) NA (NA, NA) 0 (0, 0.213) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 18 18 18 18 18 18 18 18
AR- & TP53- TC1 time 7 (5, 12) 7 (5, 12) 7 (5, 12) 7 (5, 12) 7 (5, 12) 7 (5, 12) 7 (5, 12) 7 (5, 12)
AR- & TP53- TC1 n 26 (21, 31) 4 (1, 6) 1 (0, 3) 1 (0, 3) 0 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 2)
AR- & TP53- TC1 post_p 0.86 (0.74, 0.94) 0.57 (0.52, 0.73) 0.55 (0.53, 0.57) 0.53 (0.5, 0.61) 0.56 (0.53, 0.63) NA (NA, NA) 0.56 (0.52, 0.71) 0.58 (0.53, 0.65)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.075 (0.032, 0.089) 0.011 (0, 0.091) 0 (0, 0.178) 0 (0, 0.194) 0 (0, 0.104) NA (NA, NA) 0 (0, 0.171) 0.055 (0, 0.291)
AR- & TP53- TC2 count 27 27 27 27 27 27 27 27
AR- & TP53- TC2 time 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13)
AR- & TP53- TC2 n 21 (17, 33) 3 (1, 6) 1 (0, 2) 1 (0, 3) 3 (1, 5) 0 (0, 0) 0 (0, 2) 1 (0, 2)
AR- & TP53- TC2 post_p 0.84 (0.73, 0.94) 0.58 (0.52, 0.75) 0.53 (0.51, 0.57) 0.55 (0.51, 0.63) 0.58 (0.53, 0.71) 0.55 (0.55, 0.55) 0.58 (0.53, 0.67) 0.57 (0.53, 0.65)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.066 (0.046, 0.099) 0 (0, 0.068) 0.056 (0, 0.232) 0 (0, 0.06) 0 (0, 0.088) 0 (0, 0) 0 (0, 0.067) 0 (0, 0.061)
AR- & TP53- TC3 count 10 10 10 10 10 10 10 10
AR- & TP53- TC3 time 10 (9, 13) 10 (9, 13) 10 (9, 13) 10 (9, 13) 10 (9, 13) 10 (9, 13) 10 (9, 13) 10 (9, 13)
AR- & TP53- TC3 n 14 (11, 31) 4 (2, 5) 0 (0, 1) 1 (0, 3) 5 (4, 9) 0 (0, 0) 2 (1, 4) 1 (0, 3)
AR- & TP53- TC3 post_p 0.81 (0.79, 0.87) 0.56 (0.51, 0.62) 0.55 (0.55, 0.55) 0.55 (0.52, 0.6) 0.76 (0.52, 0.91) NA (NA, NA) 0.56 (0.52, 0.67) NA (NA, NA)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.036 (0.019, 0.074) 0.026 (0, 0.128) 0 (0, 0.243) 0 (0, 0) 0.046 (0, 0.078) NA (NA, NA) 0.029 (0, 0.1) 0.149 (0.016, 0.431)
AR- & TP53- TC4 count 14 14 14 14 14 14 14 14
AR- & TP53- TC4 time 11 (9, 15) 11 (9, 15) 11 (9, 15) 11 (9, 15) 11 (9, 15) 11 (9, 15) 11 (9, 15) 11 (9, 15)
AR- & TP53- TC4 n 18 (13, 25) 3 (0, 6) 0 (0, 1) 1 (0, 3) 5 (3, 8) 0 (0, 0) 4 (0, 6) 1 (0, 3)
AR- & TP53- TC4 post_p 0.84 (0.75, 0.94) 0.56 (0.52, 0.81) 0.56 (0.55, 0.59) 0.55 (0.52, 0.78) 0.62 (0.52, 0.81) NA (NA, NA) 0.64 (0.52, 0.83) 0.61 (0.55, 0.74)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.055 (0.03, 0.098) 0 (0, 0.126) 0 (0, 0) 0 (0, 0.016) 0.043 (0, 0.096) 0.664 (0.664, 0.664) 0.044 (0, 0.18) 0.017 (0, 0.191)
AR- & TP53- TC5 count 60 60 60 60 60 60 60 60
AR- & TP53- TC5 time 12 (9, 25) 12 (9, 25) 12 (9, 25) 12 (9, 25) 12 (9, 25) 12 (9, 25) 12 (9, 25) 12 (9, 25)
AR- & TP53- TC5 n 16 (9, 38) 8 (4, 12) 0 (0, 2) 4 (2, 8) 3 (1, 8) 0 (0, 0) 2 (0, 4) 0 (0, 2)
AR- & TP53- TC5 post_p 0.78 (0.71, 0.88) 0.79 (0.64, 0.95) 0.59 (0.53, 0.68) 0.65 (0.52, 0.92) 0.59 (0.52, 0.76) NA (NA, NA) 0.59 (0.52, 0.76) 0.55 (0.52, 0.73)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.073 (0.021, 0.101) 0.028 (0, 0.057) 0 (0, 0.175) 0.035 (0, 0.064) 0.062 (0, 0.103) NA (NA, NA) 0 (0, 0.148) 0 (0, 0.082)
HRD+ TC1 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
HRD+ TC1 time 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29) 29 (25, 29)
HRD+ TC1 n 15 (5, 18) 0 (0, 0) 7 (5, 12) 2 (1, 4) 0 (0, 0) 2 (1, 3) 0 (0, 1) 2 (1, 4) 5 (3, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.76 (0.64, 0.79) NA (NA, NA) 0.74 (0.68, 0.84) 0.58 (0.53, 0.72) NA (NA, NA) 0.61 (0.57, 0.66) NA (NA, NA) 0.58 (0.54, 0.71) 0.71 (0.59, 0.82) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.075 (0.064, 0.097) NA (NA, NA) 0.066 (0.048, 0.08) 0.07 (0.017, 0.12) NA (NA, NA) 0.065 (0.026, 0.244) 0 (0, 0) 0.054 (0, 0.076) 0.078 (0.043, 0.099) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
HRD+ TC2 time 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33)
HRD+ TC2 n 14 (9, 20) 0 (0, 0) 5 (2, 10) 1 (0, 4) 0 (0, 0) 1 (0, 2) 0 (0, 0) 2 (0, 3) 4 (2, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.82 (0.75, 0.88) NA (NA, NA) 0.82 (0.53, 0.87) 0.61 (0.55, 0.65) NA (NA, NA) 0.58 (0.54, 0.73) NA (NA, NA) 0.58 (0.53, 0.66) 0.62 (0.5, 0.82) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.079 (0.063, 0.098) NA (NA, NA) 0.069 (0.044, 0.116) 0.036 (0, 0.103) NA (NA, NA) 0.035 (0, 0.087) NA (NA, NA) 0.109 (0, 0.149) 0.081 (0.036, 0.117) NA (NA, NA) 0.075 (0.015, 0.135) NA (NA, NA) 0.225 (0.225, 0.225) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
HRD+ TC3 time 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29) 22 (19, 29)
HRD+ TC3 n 19 (13, 20) 0 (0, 0) 4 (2, 6) 3 (0, 5) 0 (0, 0) 0 (0, 4) 0 (0, 0) 1 (1, 2) 4 (3, 9) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
HRD+ TC3 post_p 0.86 (0.82, 0.88) NA (NA, NA) 0.64 (0.53, 0.8) 0.62 (0.53, 0.71) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.56 (0.52, 0.57) 0.56 (0.51, 0.75) NA (NA, NA) 0.54 (0.51, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.062 (0.058, 0.098) NA (NA, NA) 0.08 (0.064, 0.101) 0.164 (0.091, 0.428) NA (NA, NA) 0.122 (0.076, 0.168) NA (NA, NA) 0 (0, 0.233) 0.077 (0.059, 0.109) NA (NA, NA) 0 (0, 0.418) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.234 (0.234, 0.234)
HRD+ TC4 count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
HRD+ TC4 time 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29) 23 (17, 29)
HRD+ TC4 n 13 (8, 19) 0 (0, 0) 5 (3, 12) 3 (2, 4) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (1, 3) 3 (1, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.84 (0.72, 0.92) NA (NA, NA) 0.74 (0.63, 0.86) 0.57 (0.51, 0.77) NA (NA, NA) 0.56 (0.52, 0.68) NA (NA, NA) 0.53 (0.51, 0.69) 0.63 (0.55, 0.79) NA (NA, NA) 0.57 (0.54, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.077 (0.057, 0.098) NA (NA, NA) 0.073 (0.023, 0.121) 0.073 (0, 0.122) NA (NA, NA) 0.023 (0, 0.128) NA (NA, NA) 0.09 (0, 0.578) 0.083 (0.023, 0.153) NA (NA, NA) 0.112 (0, 0.422) NA (NA, NA) 0.745 (0.745, 0.745) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 count 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17
HRD+ TC5 time 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32) 25 (22, 32)
HRD+ TC5 n 14 (11, 18) 0 (0, 0) 6 (3, 10) 1 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 3 (2, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.8 (0.74, 0.92) NA (NA, NA) 0.73 (0.6, 0.86) 0.66 (0.54, 0.77) NA (NA, NA) 0.58 (0.53, 0.68) NA (NA, NA) 0.61 (0.54, 0.74) 0.55 (0.51, 0.74) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.083 (0.057, 0.102) NA (NA, NA) 0.074 (0.017, 0.112) 0 (0, 0.147) NA (NA, NA) 0.02 (0, 0.093) 3.623 (3.623, 3.623) 0 (0, 0) 0.099 (0, 0.164) NA (NA, NA) 0.173 (0.088, 0.209) NA (NA, NA) 0.054 (0.015, 0.086) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TP53+ TC1 time 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19)
TP53+ TC1 n 11 (11, 11) 14 (14, 14) 5 (5, 5) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 7 (7, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.7 (0.7, 0.7) 0.76 (0.76, 0.76) 0.69 (0.69, 0.69) 0.8 (0.8, 0.8) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.72 (0.72, 0.72) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.086 (0.086, 0.086) 0.089 (0.089, 0.089) 0.114 (0.114, 0.114) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.088 (0.088, 0.088) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TP53+ TC2 time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
TP53+ TC2 n 2 (2, 2) 4 (4, 4) 2 (2, 2) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 1 (1, 1) 17 (17, 17) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.52 (0.52, 0.52) 0.63 (0.63, 0.63) 0.66 (0.66, 0.66) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.93 (0.93, 0.93) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.132 (0.132, 0.132) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.116 (0.116, 0.116) 0.021 (0.021, 0.021) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TP53+ TC3 time 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20) 18 (16, 20)
TP53+ TC3 n 5 (4, 6) 5 (4, 7) 1 (1, 4) 6 (4, 8) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 4) 3 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0)
TP53+ TC3 post_p 0.68 (0.55, 0.88) 0.59 (0.54, 0.74) 0.56 (0.54, 0.73) 0.76 (0.63, 0.77) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.62 (0.62, 0.62) NA (NA, NA) NA (NA, NA) 0.57 (0.53, 0.61) 0.61 (0.56, 0.65) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.104 (0.06, 0.108) 0.053 (0.045, 0.071) 0 (0, 0.035) 0.07 (0.04, 0.114) NA (NA, NA) 0.79 (0.208, 1.373) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.071 (0.014, 0.127) 0.074 (0.015, 0.075) NA (NA, NA) NA (NA, NA) 0.185 (0.185, 0.185) NA (NA, NA)
TP53+ TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TP53+ TC4 time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
TP53+ TC4 n 4 (4, 4) 6 (6, 6) 2 (2, 2) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 3 (3, 3) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.58 (0.58, 0.58) 0.71 (0.71, 0.71) 0.54 (0.54, 0.54) 0.58 (0.58, 0.58) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.75 (0.75, 0.75) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.056 (0.056, 0.056) 0 (0, 0) 0.239 (0.239, 0.239) 0.089 (0.089, 0.089) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.251 (0.251, 0.251) NA (NA, NA) NA (NA, NA) 0.058 (0.058, 0.058) 0.043 (0.043, 0.043) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 count 61 61 61 61 61 61 61 61 61 61 61 61 61 61 61 61
TP53+ TC5 time 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25) 16 (12, 25)
TP53+ TC5 n 5 (2, 13) 8 (4, 13) 1 (0, 3) 6 (3, 9) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 4 (1, 8) 5 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.7 (0.52, 0.85) 0.82 (0.65, 0.96) 0.56 (0.51, 0.69) 0.76 (0.55, 0.95) NA (NA, NA) 0.55 (0.52, 0.62) NA (NA, NA) 0.57 (0.51, 0.65) 0.56 (0.54, 0.59) NA (NA, NA) 0.66 (0.52, 0.82) 0.72 (0.56, 0.93) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.073 (0.022, 0.111) 0.038 (0, 0.067) 0.063 (0, 0.169) 0.033 (0, 0.072) 0 (0, 0) 0 (0, 0.167) NA (NA, NA) 0 (0, 0.18) 0 (0, 0.251) 0.233 (0.047, 0.42) 0.065 (0, 0.125) 0.03 (0, 0.07) 0.055 (0.011, 0.529) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC1 time 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17) 15 (12, 17)
TEfus+ TC1 n 1 (0, 3) 4 (3, 5) 1 (0, 2) 4 (1, 4) 3 (2, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (1, 4) 2 (2, 2) 5 (4, 7) 3 (3, 4) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.56 (0.56, 0.56) 0.81 (0.73, 0.83) 0.52 (0.52, 0.52) 0.67 (0.57, 0.77) 0.61 (0.54, 0.78) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.58 (0.56, 0.72) 0.53 (0.51, 0.55) 0.53 (0.51, 0.7) 0.53 (0.53, 0.57) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.037 (0.007, 0.067) 0.091 (0.018, 0.095) 0 (0, 0) 0.058 (0.04, 0.075) 0 (0, 0.067) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.113 (0.023, 0.151) 0.07 (0.063, 0.09) 0.074 (0.054, 0.122) 0.085 (0.076, 0.097) NA (NA, NA) 0.542 (0.215, 0.869) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC3 time 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21) 19 (17, 21)
TEfus+ TC3 n 0 (0, 0) 1 (0, 2) 1 (1, 2) 5 (3, 8) 4 (2, 7) 1 (0, 1) 0 (0, 0) 1 (0, 1) 2 (2, 3) 0 (0, 2) 3 (1, 9) 5 (3, 5) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1)
TEfus+ TC3 post_p NA (NA, NA) 0.52 (0.52, 0.54) 0.56 (0.53, 0.6) 0.56 (0.52, 0.67) 0.77 (0.62, 0.79) 0.59 (0.58, 0.61) NA (NA, NA) 0.52 (0.52, 0.52) 0.67 (0.66, 0.87) 0.57 (0.57, 0.57) 0.72 (0.58, 0.73) 0.65 (0.59, 0.67) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate NA (NA, NA) 0.028 (0.006, 0.05) 0.078 (0.016, 0.127) 0.039 (0.039, 0.082) 0.061 (0.049, 0.074) 0 (0, 0) NA (NA, NA) 0.134 (0.112, 0.156) 0 (0, 0.038) 0 (0, 0) 0.051 (0.01, 0.066) 0.079 (0.041, 0.087) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TEfus+ TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC4 time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
TEfus+ TC4 n 0 (0, 0) 3 (3, 3) 2 (2, 2) 1 (1, 1) 5 (5, 5) 2 (2, 2) 0 (0, 0) 2 (2, 2) 1 (1, 1) 1 (1, 1) 4 (4, 4) 3 (3, 3) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p NA (NA, NA) 0.57 (0.57, 0.57) 0.57 (0.57, 0.57) 0.51 (0.51, 0.51) 0.8 (0.8, 0.8) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.54, 0.54) 0.84 (0.84, 0.84) 0.61 (0.61, 0.61) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.117 (0.117, 0.117) 0.037 (0.037, 0.037) 0.057 (0.057, 0.057) NA (NA, NA) 0.666 (0.666, 0.666) 0.951 (0.951, 0.951) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34
TEfus+ TC5 time 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27) 16 (12, 27)
TEfus+ TC5 n 1 (0, 4) 4 (2, 8) 1 (0, 4) 6 (3, 9) 2 (0, 4) 1 (0, 3) 0 (0, 0) 0 (0, 1) 1 (0, 3) 1 (0, 3) 4 (1, 8) 5 (3, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.57 (0.52, 0.64) 0.72 (0.54, 0.86) 0.55 (0.51, 0.62) 0.77 (0.6, 0.95) 0.57 (0.52, 0.78) 0.58 (0.53, 0.7) NA (NA, NA) 0.61 (0.51, 0.73) 0.56 (0.5, 0.67) 0.59 (0.55, 0.63) 0.66 (0.54, 0.82) 0.72 (0.55, 0.9) 0.59 (0.59, 0.59) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.057 (0, 0.184) 0.034 (0, 0.062) 0.055 (0, 0.132) 0.036 (0, 0.086) 0.061 (0, 0.109) 0 (0, 0.043) NA (NA, NA) 0 (0, 0.206) 0.062 (0, 0.162) 0 (0, 0.058) 0.061 (0, 0.12) 0.036 (0, 0.062) 0 (0, 3.963) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
PI3K+ TC2 time 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17)
PI3K+ TC2 n 5 (5, 5) 3 (3, 3) 4 (4, 4) 4 (4, 4) 0 (0, 0) 1 (1, 1) 1 (1, 1) 3 (3, 3) 1 (1, 1) 2 (2, 2) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.52 (0.52, 0.52) 0.72 (0.72, 0.72) 0.52 (0.52, 0.52) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) 0.67 (0.67, 0.67) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.108 (0.108, 0.108) 0 (0, 0) 0.056 (0.056, 0.056) 0.071 (0.071, 0.071) NA (NA, NA) 0.202 (0.202, 0.202) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.214 (0.214, 0.214) NA (NA, NA) 0.093 (0.093, 0.093) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
PI3K+ TC3 time 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16)
PI3K+ TC3 n 8 (8, 8) 2 (2, 2) 8 (8, 8) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 6 (6, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.83 (0.83, 0.83) 0.56 (0.56, 0.56) 0.76 (0.76, 0.76) 0.65 (0.65, 0.65) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.73 (0.73, 0.73) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.048 (0.048, 0.048) 0.078 (0.078, 0.078) 0.037 (0.037, 0.037) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.162 (0.162, 0.162) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.09 (0.09, 0.09) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC4 time 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20) 17 (14, 20)
PI3K+ TC4 n 10 (6, 13) 2 (1, 3) 6 (4, 8) 1 (0, 2) 0 (0, 0) 4 (4, 4) 2 (1, 3) 2 (1, 2) 1 (0, 2) 2 (1, 2) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.68 (0.55, 0.81) 0.62 (0.57, 0.67) 0.75 (0.58, 0.92) 0.53 (0.53, 0.53) NA (NA, NA) 0.57 (0.52, 0.62) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) 0.65 (0.55, 0.76) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.069 (0.063, 0.075) 0 (0, 0) 0.099 (0.065, 0.134) 0.073 (0.073, 0.073) NA (NA, NA) 0.085 (0.074, 0.095) 0.226 (0.17, 0.282) 0.047 (0.009, 0.085) 0.039 (0.039, 0.039) 0.019 (0.004, 0.035) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 count 312 312 312 312 312 312 312 312 312 312 312 312 312 312 312 312
PI3K+ TC5 time 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28) 17 (11, 28)
PI3K+ TC5 n 11 (5, 23) 4 (2, 10) 9 (4, 18) 7 (3, 13) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 4) 0 (0, 0) 5 (2, 12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.86 (0.68, 1) 0.72 (0.54, 0.94) 0.82 (0.6, 0.99) 0.75 (0.54, 0.98) NA (NA, NA) 0.59 (0.52, 0.8) 0.56 (0.52, 0.72) 0.57 (0.51, 0.69) 0.56 (0.51, 0.67) 0.58 (0.52, 0.75) NA (NA, NA) 0.74 (0.55, 0.96) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.036 (0, 0.065) 0.036 (0, 0.082) 0.036 (0, 0.069) 0.033 (0, 0.077) 0 (0, 0) 0 (0, 0.11) 0 (0, 0.121) 0 (0, 0.098) 0 (0, 0.119) 0 (0, 0.123) 0 (0, 0.262) 0.036 (0, 0.077) 0.166 (0.166, 0.166) 0 (0, 0) 0 (0, 0.092) 0 (0, 0)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
all TC1 time 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22) 4 (4, 22)
all TC1 n 18 (15, 22) 2 (1, 4) 0 (0, 3) 0 (0, 3) 4 (1, 8) 2 (0, 6) 0 (0, 2) 0 (0, 3) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 1 (0, 3) 2 (0, 3) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.39 (0.2, 0.47) 0.43 (0.32, 0.49) 0.34 (0.27, 0.42) 0.38 (0.2, 0.4) 0.41 (0.29, 0.48) 0.46 (0.4, 0.49) 0.39 (0.37, 0.45) 0.42 (0.37, 0.46) 0.38 (0.24, 0.47) NA (NA, NA) 0.42 (0.42, 0.42) 0.45 (0.45, 0.46) NA (NA, NA) 0.4 (0.4, 0.4) NA (NA, NA) NA (NA, NA) 0.41 (0.36, 0.42) NA (NA, NA) 0.44 (0.39, 0.48) 0.34 (0.34, 0.34) NA (NA, NA) NA (NA, NA) 0.43 (0.32, 0.48) 0.42 (0.3, 0.46) 0.44 (0.43, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.132 (0.098, 0.229) 0.261 (0.074, 0.676) 0.147 (0, 0.22) 0.41 (0.186, 0.462) 0.152 (0, 0.335) 0.086 (0, 1.759) 0.22 (0.215, 0.229) 0.255 (0.124, 0.579) 0.782 (0.067, 28.623) NA (NA, NA) 0.122 (0.122, 0.122) 0.151 (0.145, 0.158) NA (NA, NA) 0.281 (0.056, 0.505) NA (NA, NA) 0 (0, 0) 0.203 (0, 1.673) 0.474 (0.203, 7.183) 0 (0, 1.785) 0.103 (0.021, 0.186) NA (NA, NA) NA (NA, NA) 0.287 (0.064, 0.435) 0.121 (0, 0.19) 0.038 (0.008, 0.416) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.118 (0.118, 0.118) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC2 time 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17) 12 (7, 17)
all TC2 n 12 (9, 36) 1 (0, 2) 1 (0, 2) 0 (0, 1) 4 (2, 4) 3 (1, 4) 2 (1, 2) 3 (2, 4) 4 (1, 5) 0 (0, 0) 2 (0, 3) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 3) 1 (0, 2) 0 (0, 2) 3 (1, 4) 0 (0, 1) 0 (0, 1) 0 (0, 0) 6 (5, 6) 2 (1, 4) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0)
all TC2 post_p 0.31 (0.15, 0.49) 0.39 (0.28, 0.41) 0.46 (0.41, 0.47) 0.4 (0.4, 0.4) 0.46 (0.29, 0.49) 0.43 (0.41, 0.46) 0.42 (0.42, 0.43) 0.44 (0.38, 0.47) 0.41 (0.33, 0.44) NA (NA, NA) 0.34 (0.32, 0.37) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.43 (0.39, 0.46) 0.46 (0.42, 0.49) 0.5 (0.5, 0.5) 0.39 (0.36, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.37 (0.21, 0.42) 0.41 (0.34, 0.45) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.15 (0.112, 0.186) 0.289 (0.247, 0.958) 0.591 (0.273, 1.343) 0.302 (0.302, 0.302) 0.102 (0.028, 0.235) 0.106 (0.095, 0.195) 0.142 (0.038, 0.171) 0.144 (0.122, 0.267) 0.12 (0.118, 0.336) NA (NA, NA) 0.155 (0.031, 0.242) 0.313 (0.063, 0.564) NA (NA, NA) 0.441 (0.441, 0.441) NA (NA, NA) 0.522 (0.202, 0.842) 0.138 (0.091, 0.184) 0.272 (0.054, 0.49) 0.157 (0.111, 0.164) 0 (0, 0) 0.082 (0.082, 0.082) NA (NA, NA) 0.175 (0.138, 0.201) 0.212 (0.168, 1.386) 7.544 (7.544, 7.544) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
all TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC3 time 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33)
all TC3 n 9 (7, 11) 6 (1, 10) 0 (0, 0) 3 (2, 4) 7 (3, 11) 2 (1, 2) 1 (0, 2) 6 (3, 8) 4 (3, 6) 0 (0, 0) 4 (4, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 1 (1, 1) 0 (0, 0) 2 (1, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 6 (3, 10) 2 (1, 4) 1 (1, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.33 (0.22, 0.44) 0.31 (0.31, 0.31) NA (NA, NA) 0.42 (0.41, 0.43) 0.45 (0.42, 0.49) 0.3 (0.25, 0.34) 0.23 (0.23, 0.23) 0.41 (0.35, 0.46) 0.26 (0.15, 0.37) NA (NA, NA) 0.31 (0.3, 0.32) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.43 (0.43, 0.43) 0.39 (0.38, 0.4) NA (NA, NA) 0.36 (0.34, 0.38) 0.36 (0.36, 0.36) NA (NA, NA) NA (NA, NA) 0.47 (0.46, 0.47) 0.4 (0.39, 0.41) 0.38 (0.33, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.19 (0.155, 0.224) 0.156 (0.156, 0.156) NA (NA, NA) 0.147 (0.143, 0.151) 0.116 (0.106, 0.125) 0.518 (0.456, 0.579) 1.236 (1.236, 1.236) 0.354 (0.14, 0.568) 0.202 (0.199, 0.205) NA (NA, NA) 0.238 (0.191, 0.285) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.07 (0.07, 0.07) 0.188 (0.188, 0.188) 0.551 (0.33, 0.773) NA (NA, NA) 0.607 (0.335, 0.88) 0.348 (0.348, 0.348) 0.152 (0.152, 0.152) NA (NA, NA) 0.5 (0.19, 0.811) 3.945 (0.894, 6.997) 5.065 (1.759, 8.371) NA (NA, NA) 0 (0, 0) NA (NA, NA) 1.014 (1.014, 1.014) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 104 104 104 104 104 104 104 104
AR- & TP53- TC1 time 13 (5, 25) 13 (5, 25) 13 (5, 25) 13 (5, 25) 13 (5, 25) 13 (5, 25) 13 (5, 25) 13 (5, 25)
AR- & TP53- TC1 n 22 (15, 45) 5 (2, 10) 1 (0, 4) 2 (0, 6) 3 (0, 8) 0 (0, 0) 1 (0, 5) 0 (0, 2)
AR- & TP53- TC1 post_p 0.31 (0.12, 0.46) 0.37 (0.18, 0.48) 0.42 (0.31, 0.48) 0.41 (0.25, 0.49) 0.41 (0.21, 0.48) NA (NA, NA) 0.4 (0.24, 0.48) 0.45 (0.35, 0.49)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.129 (0.105, 0.176) 0.152 (0.086, 0.361) 0.188 (0.062, 0.73) 0.16 (0.059, 0.457) 0.172 (0.102, 0.429) 0.147 (0.029, 0.643) 0.205 (0.087, 0.719) 0.156 (0, 0.656)
AR- & TP53- TC2 count 79 79 79 79 79 79 79 79
AR- & TP53- TC2 time 20 (12, 33) 20 (12, 33) 20 (12, 33) 20 (12, 33) 20 (12, 33) 20 (12, 33) 20 (12, 33) 20 (12, 33)
AR- & TP53- TC2 n 20 (10, 72) 5 (2, 13) 1 (0, 3) 3 (1, 6) 5 (1, 10) 0 (0, 0) 3 (1, 6) 1 (0, 3)
AR- & TP53- TC2 post_p 0.3 (0.07, 0.48) 0.36 (0.17, 0.47) 0.42 (0.3, 0.48) 0.39 (0.23, 0.48) 0.37 (0.21, 0.48) NA (NA, NA) 0.37 (0.19, 0.47) 0.43 (0.34, 0.49)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.128 (0.105, 0.219) 0.153 (0.094, 0.363) 0.206 (0.074, 1.361) 0.163 (0.095, 0.367) 0.158 (0.101, 0.544) 0.241 (0.048, 0.434) 0.198 (0.112, 0.733) 0.166 (0, 0.542)
AR- & TP53- TC3 count 68 68 68 68 68 68 68 68
AR- & TP53- TC3 time 22 (12, 31) 22 (12, 31) 22 (12, 31) 22 (12, 31) 22 (12, 31) 22 (12, 31) 22 (12, 31) 22 (12, 31)
AR- & TP53- TC3 n 18 (8, 55) 4 (2, 13) 1 (0, 3) 3 (1, 6) 6 (4, 15) 0 (0, 0) 4 (1, 7) 2 (0, 4)
AR- & TP53- TC3 post_p 0.31 (0.11, 0.46) 0.36 (0.17, 0.47) 0.45 (0.36, 0.49) 0.4 (0.2, 0.48) 0.34 (0.15, 0.47) NA (NA, NA) 0.38 (0.21, 0.47) 0.41 (0.29, 0.48)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.132 (0.109, 0.197) 0.162 (0.109, 0.338) 0.175 (0.074, 0.62) 0.162 (0.091, 0.729) 0.166 (0.1, 0.289) 0.3 (0.266, 0.53) 0.183 (0.087, 0.419) 0.199 (0.064, 1.427)
AR- & TP53- TC4 count 78 78 78 78 78 78 78 78
AR- & TP53- TC4 time 16 (11, 29) 16 (11, 29) 16 (11, 29) 16 (11, 29) 16 (11, 29) 16 (11, 29) 16 (11, 29) 16 (11, 29)
AR- & TP53- TC4 n 19 (8, 45) 4 (1, 11) 1 (0, 2) 2 (1, 6) 6 (3, 14) 0 (0, 0) 4 (1, 7) 1 (0, 4)
AR- & TP53- TC4 post_p 0.32 (0.14, 0.45) 0.38 (0.18, 0.48) 0.41 (0.32, 0.47) 0.39 (0.23, 0.47) 0.32 (0.17, 0.46) NA (NA, NA) 0.41 (0.2, 0.49) 0.4 (0.28, 0.46)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.139 (0.107, 0.214) 0.154 (0.087, 0.399) 0.195 (0, 0.89) 0.202 (0.103, 0.575) 0.161 (0.105, 0.293) 0.155 (0.042, 0.25) 0.16 (0.095, 0.346) 0.2 (0.057, 0.786)
AR- & TP53- TC5 count 2 2 2 2 2 2 2 2
AR- & TP53- TC5 time 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33)
AR- & TP53- TC5 n 8 (7, 8) 18 (8, 27) 1 (0, 2) 4 (2, 6) 8 (4, 12) 0 (0, 0) 4 (4, 4) 2 (1, 3)
AR- & TP53- TC5 post_p 0.12 (0.08, 0.15) 0.44 (0.42, 0.46) 0.5 (0.5, 0.5) 0.35 (0.26, 0.45) 0.28 (0.12, 0.45) NA (NA, NA) 0.35 (0.32, 0.38) 0.32 (0.32, 0.32)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.24 (0.232, 0.249) 0.078 (0.055, 0.101) 0.09 (0.09, 0.09) 0.209 (0.112, 0.306) 0.219 (0.126, 0.311) NA (NA, NA) 0.188 (0.171, 0.206) 0.074 (0.015, 0.133)
HRD+ TC1 count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
HRD+ TC1 time 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36) 29 (27, 36)
HRD+ TC1 n 10 (7, 17) 0 (0, 1) 5 (3, 10) 2 (0, 5) 0 (0, 0) 2 (1, 5) 0 (0, 0) 2 (0, 4) 4 (2, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.37 (0.16, 0.48) NA (NA, NA) 0.29 (0.12, 0.45) 0.37 (0.28, 0.47) NA (NA, NA) 0.42 (0.33, 0.49) NA (NA, NA) 0.37 (0.22, 0.46) 0.37 (0.19, 0.44) NA (NA, NA) 0.5 (0.49, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.131 (0.106, 0.188) 0.213 (0.13, 0.296) 0.167 (0.122, 0.395) 0.252 (0.075, 0.566) NA (NA, NA) 0.161 (0.111, 0.411) NA (NA, NA) 0.223 (0.087, 1.134) 0.158 (0.12, 0.25) NA (NA, NA) 0.105 (0.074, 0.137) 0.82 (0.82, 0.82) 0.074 (0.015, 0.133) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16
HRD+ TC2 time 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34) 32 (26, 34)
HRD+ TC2 n 13 (7, 22) 0 (0, 0) 5 (2, 11) 3 (1, 5) 0 (0, 0) 2 (0, 3) 0 (0, 0) 1 (0, 2) 4 (1, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.36 (0.16, 0.49) NA (NA, NA) 0.33 (0.19, 0.48) 0.38 (0.24, 0.48) NA (NA, NA) 0.41 (0.32, 0.46) NA (NA, NA) 0.44 (0.39, 0.48) 0.4 (0.35, 0.49) NA (NA, NA) 0.47 (0.44, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.126 (0.103, 0.219) NA (NA, NA) 0.165 (0.101, 0.245) 0.186 (0.098, 0.506) NA (NA, NA) 0.164 (0.046, 0.246) NA (NA, NA) 0.211 (0.068, 0.827) 0.141 (0.114, 0.714) 0.207 (0.041, 0.373) 0.13 (0.093, 0.522) 0.527 (0.527, 0.527) 0.26 (0.26, 0.26) 0 (0, 0) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 38 38 38 38 38 38 38 38 38 38 38 38 38 38 38 38
HRD+ TC3 time 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35) 30 (22, 35)
HRD+ TC3 n 12 (6, 20) 0 (0, 0) 6 (3, 10) 2 (1, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 2 (0, 3) 4 (1, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.38 (0.2, 0.48) 0.48 (0.48, 0.48) 0.38 (0.21, 0.48) 0.36 (0.22, 0.44) NA (NA, NA) 0.41 (0.3, 0.47) NA (NA, NA) 0.42 (0.32, 0.49) 0.39 (0.27, 0.48) NA (NA, NA) 0.43 (0.37, 0.49) NA (NA, NA) 0.46 (0.45, 0.48) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.122 (0.097, 0.177) 0.104 (0.021, 0.158) 0.141 (0.109, 0.281) 0.219 (0.099, 0.427) 0.095 (0.095, 0.095) 0.217 (0.112, 0.86) 0.187 (0.172, 0.202) 0.17 (0.105, 0.811) 0.185 (0.1, 0.597) NA (NA, NA) 0.287 (0.012, 1.38) 0.091 (0.091, 0.091) 0.079 (0, 0.206) 0 (0, 0) 0.048 (0, 1.401) NA (NA, NA)
HRD+ TC4 count 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34
HRD+ TC4 time 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34) 28 (21, 34)
HRD+ TC4 n 10 (6, 17) 0 (0, 0) 6 (3, 10) 3 (1, 4) 0 (0, 0) 1 (0, 4) 0 (0, 0) 2 (0, 3) 4 (2, 9) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.35 (0.21, 0.45) NA (NA, NA) 0.35 (0.21, 0.47) 0.37 (0.26, 0.47) NA (NA, NA) 0.41 (0.26, 0.48) NA (NA, NA) 0.39 (0.26, 0.48) 0.35 (0.27, 0.47) 0.46 (0.46, 0.46) 0.46 (0.34, 0.5) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.139 (0.105, 0.189) NA (NA, NA) 0.151 (0.12, 0.289) 0.163 (0.09, 0.475) 0.193 (0.193, 0.193) 0.228 (0.1, 1.042) 0.111 (0.022, 0.178) 0.134 (0.084, 0.703) 0.148 (0.1, 0.624) 0.097 (0.019, 0.176) 0.192 (0.014, 2.116) 0.138 (0.138, 0.138) 0.039 (0, 0.719) NA (NA, NA) 0.163 (0.163, 0.163) 0.246 (0.177, 1.188)
HRD+ TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
HRD+ TC5 time 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35)
HRD+ TC5 n 10 (5, 14) 0 (0, 0) 10 (4, 15) 1 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (1, 1) 4 (2, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.19 (0.17, 0.22) NA (NA, NA) 0.47 (0.46, 0.49) 0.49 (0.49, 0.49) NA (NA, NA) 0.37 (0.37, 0.37) NA (NA, NA) NA (NA, NA) 0.34 (0.34, 0.34) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.206 (0.144, 0.269) NA (NA, NA) 0.094 (0.082, 0.106) 0.13 (0.13, 0.13) NA (NA, NA) 0.232 (0.232, 0.232) NA (NA, NA) 0.601 (0.12, 1.082) 0.51 (0.406, 0.614) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 55 55 55 55 55 55 55 55 55 55 55 55 55 55 55 55
TP53+ TC1 time 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31) 22 (15, 31)
TP53+ TC1 n 8 (4, 15) 6 (3, 10) 2 (0, 5) 5 (2, 9) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 5 (2, 9) 4 (1, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.36 (0.12, 0.49) 0.32 (0.14, 0.47) 0.42 (0.25, 0.48) 0.36 (0.21, 0.48) NA (NA, NA) 0.45 (0.41, 0.48) NA (NA, NA) 0.42 (0.25, 0.48) 0.44 (0.36, 0.46) NA (NA, NA) 0.36 (0.14, 0.48) 0.38 (0.3, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.139 (0.102, 0.342) 0.145 (0.089, 0.313) 0.214 (0.102, 1.2) 0.151 (0.099, 0.301) 0.204 (0.041, 0.367) 0.167 (0, 3.224) 15.128 (15.128, 15.128) 0.124 (0, 0.44) 0.17 (0, 1.172) NA (NA, NA) 0.168 (0.11, 0.378) 0.143 (0.1, 0.54) 0.303 (0.137, 2.222) 0 (0, 0) 1.176 (1.176, 1.176) 0.24 (0.048, 0.279)
TP53+ TC2 count 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52 52
TP53+ TC2 time 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32)
TP53+ TC2 n 6 (3, 13) 5 (2, 11) 2 (0, 6) 4 (2, 10) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 1 (0, 2) 0 (0, 0) 6 (3, 12) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.3 (0.16, 0.45) 0.36 (0.21, 0.5) 0.42 (0.23, 0.48) 0.36 (0.16, 0.48) NA (NA, NA) 0.46 (0.35, 0.49) NA (NA, NA) 0.42 (0.37, 0.47) 0.48 (0.44, 0.5) NA (NA, NA) 0.34 (0.18, 0.48) 0.32 (0.21, 0.44) 0.43 (0.41, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.156 (0.113, 0.342) 0.142 (0.079, 0.27) 0.183 (0.089, 0.724) 0.145 (0.074, 0.492) 0.235 (0.154, 0.316) 0.12 (0.013, 1.211) 0 (0, 0) 0.146 (0, 0.874) 0.125 (0, 1.117) 0.124 (0.025, 0.223) 0.15 (0.099, 0.274) 0.166 (0.104, 0.348) 0.827 (0.472, 1.364) 3.356 (3.356, 3.356) 4.558 (4.558, 4.558) NA (NA, NA)
TP53+ TC3 count 44 44 44 44 44 44 44 44 44 44 44 44 44 44 44 44
TP53+ TC3 time 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34) 24 (17, 34)
TP53+ TC3 n 6 (3, 14) 5 (2, 11) 2 (0, 3) 4 (2, 10) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 1) 0 (0, 0) 6 (2, 11) 5 (2, 11) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.28 (0.14, 0.48) 0.3 (0.15, 0.46) 0.41 (0.24, 0.47) 0.38 (0.23, 0.47) NA (NA, NA) 0.43 (0.32, 0.48) NA (NA, NA) 0.43 (0.37, 0.49) 0.45 (0.31, 0.47) NA (NA, NA) 0.3 (0.17, 0.46) 0.39 (0.24, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.46 (0.46, 0.46)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.144 (0.104, 0.334) 0.155 (0.1, 0.444) 0.233 (0.143, 0.416) 0.147 (0.092, 0.345) NA (NA, NA) 0.174 (0.076, 0.655) 1.919 (0.73, 3.107) 0.155 (0.08, 0.336) 0.309 (0, 0.927) 0.129 (0.127, 0.131) 0.172 (0.109, 0.569) 0.135 (0.105, 0.254) 1.134 (0, 17.925) 0.333 (0.067, 0.6) 0.094 (0.094, 0.094) 0.203 (0.041, 0.365)
TP53+ TC4 count 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41
TP53+ TC4 time 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33) 27 (18, 33)
TP53+ TC4 n 8 (3, 14) 5 (2, 10) 2 (0, 4) 4 (2, 10) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 2) 0 (0, 0) 5 (3, 11) 4 (1, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.41 (0.17, 0.48) 0.3 (0.16, 0.44) 0.41 (0.31, 0.48) 0.35 (0.16, 0.47) NA (NA, NA) 0.46 (0.3, 0.48) NA (NA, NA) 0.44 (0.37, 0.47) 0.45 (0.39, 0.48) NA (NA, NA) 0.37 (0.21, 0.49) 0.36 (0.2, 0.48) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.149 (0.103, 0.305) 0.162 (0.097, 0.356) 0.208 (0.104, 0.498) 0.157 (0.103, 0.412) 0.133 (0.133, 0.133) 0.175 (0.089, 0.44) 0.112 (0.067, 0.156) 0.178 (0.048, 0.408) 0.218 (0.108, 0.686) 0.098 (0.098, 0.098) 0.155 (0.103, 0.342) 0.182 (0.097, 0.52) 0.132 (0, 0.986) 0 (0, 0) 0.259 (0.259, 0.259) 0 (0, 0)
TEfus+ TC1 count 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29
TEfus+ TC1 time 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29) 22 (16, 29)
TEfus+ TC1 n 2 (1, 4) 3 (1, 5) 2 (1, 5) 5 (2, 9) 2 (0, 6) 1 (0, 2) 0 (0, 0) 1 (0, 2) 2 (1, 4) 1 (0, 3) 6 (3, 9) 4 (3, 8) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.4 (0.24, 0.45) 0.32 (0.2, 0.46) 0.4 (0.24, 0.46) 0.26 (0.21, 0.38) 0.39 (0.22, 0.47) 0.43 (0.31, 0.46) NA (NA, NA) 0.4 (0.3, 0.48) 0.41 (0.27, 0.47) 0.41 (0.3, 0.46) 0.36 (0.21, 0.48) 0.34 (0.23, 0.48) 0.41 (0.4, 0.41) NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.174 (0.096, 0.513) 0.162 (0.098, 0.419) 0.216 (0.121, 0.813) 0.169 (0.111, 0.427) 0.243 (0.122, 0.612) 0.19 (0.091, 0.557) 0 (0, 0) 0.151 (0, 0.338) 0.219 (0.102, 2.019) 0.167 (0.047, 0.713) 0.161 (0.095, 0.299) 0.163 (0.108, 0.278) 0.341 (0.066, 0.641) 4.278 (4.278, 4.278) NA (NA, NA) 0 (0, 0)
TEfus+ TC2 count 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26
TEfus+ TC2 time 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30)
TEfus+ TC2 n 1 (0, 4) 2 (0, 6) 3 (0, 5) 4 (2, 10) 3 (0, 6) 1 (0, 3) 0 (0, 0) 1 (0, 2) 3 (0, 5) 1 (0, 4) 6 (4, 11) 5 (3, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.43 (0.3, 0.48) 0.36 (0.27, 0.49) 0.41 (0.29, 0.48) 0.33 (0.18, 0.48) 0.36 (0.24, 0.47) 0.44 (0.32, 0.49) NA (NA, NA) 0.43 (0.39, 0.47) 0.39 (0.22, 0.48) 0.42 (0.27, 0.48) 0.33 (0.19, 0.47) 0.38 (0.2, 0.48) 0.47 (0.46, 0.49) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.227 (0.085, 1.873) 0.163 (0.081, 0.333) 0.169 (0.104, 0.349) 0.138 (0.084, 0.281) 0.192 (0.134, 1.007) 0.182 (0, 1.077) NA (NA, NA) 0.24 (0.087, 0.577) 0.172 (0.109, 0.349) 0.277 (0.057, 0.457) 0.141 (0.1, 0.288) 0.158 (0.094, 0.308) 0.157 (0.078, 0.524) 0.431 (0.431, 0.431) 2.279 (0.456, 4.102) NA (NA, NA)
TEfus+ TC3 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
TEfus+ TC3 time 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35) 30 (18, 35)
TEfus+ TC3 n 1 (0, 4) 4 (1, 9) 2 (1, 4) 4 (3, 11) 4 (1, 8) 2 (0, 3) 0 (0, 0) 1 (0, 3) 1 (1, 3) 1 (0, 3) 6 (3, 11) 4 (3, 9) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.43 (0.34, 0.46) 0.37 (0.2, 0.49) 0.4 (0.27, 0.48) 0.4 (0.27, 0.48) 0.33 (0.22, 0.44) 0.38 (0.3, 0.46) NA (NA, NA) 0.38 (0.27, 0.43) 0.4 (0.31, 0.46) 0.43 (0.35, 0.45) 0.35 (0.2, 0.48) 0.32 (0.18, 0.45) 0.46 (0.45, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.177 (0.118, 0.6) 0.149 (0.098, 0.548) 0.176 (0.111, 0.672) 0.142 (0.096, 0.249) 0.2 (0.113, 0.305) 0.201 (0.119, 1.225) 0.251 (0.106, 0.397) 0.166 (0.101, 0.286) 0.307 (0.149, 0.855) 0.175 (0.119, 0.406) 0.145 (0.104, 0.385) 0.127 (0.103, 0.242) 0.066 (0, 0.21) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22
TEfus+ TC4 time 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34) 26 (18, 34)
TEfus+ TC4 n 1 (0, 4) 2 (1, 7) 2 (0, 5) 4 (2, 8) 4 (2, 8) 2 (0, 3) 0 (0, 0) 2 (0, 3) 2 (0, 4) 1 (0, 2) 4 (3, 8) 6 (3, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.4 (0.28, 0.49) 0.33 (0.25, 0.44) 0.38 (0.27, 0.47) 0.37 (0.21, 0.48) 0.37 (0.13, 0.46) 0.37 (0.3, 0.45) NA (NA, NA) 0.45 (0.29, 0.5) 0.42 (0.26, 0.46) 0.43 (0.38, 0.49) 0.36 (0.24, 0.48) 0.37 (0.26, 0.47) 0.38 (0.33, 0.5) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.139 (0.099, 0.485) 0.194 (0.142, 0.411) 0.229 (0.12, 0.738) 0.15 (0.097, 0.426) 0.169 (0.107, 0.319) 0.192 (0.111, 0.479) 0.297 (0.297, 0.297) 0.13 (0.064, 0.421) 0.263 (0.116, 0.593) 0.2 (0.086, 0.977) 0.162 (0.117, 0.207) 0.145 (0.111, 0.232) 0.175 (0, 0.387) NA (NA, NA) 0.102 (0.102, 0.102) 0 (0, 0)
PI3K+ TC1 count 59 59 59 59 59 59 59 59 59 59 59 59 59 59 59 59
PI3K+ TC1 time 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32)
PI3K+ TC1 n 6 (3, 14) 3 (1, 6) 5 (3, 9) 6 (2, 12) 0 (0, 0) 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 3) 0 (0, 0) 4 (1, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.32 (0.11, 0.46) 0.37 (0.19, 0.48) 0.31 (0.18, 0.44) 0.3 (0.18, 0.47) NA (NA, NA) 0.42 (0.27, 0.48) 0.44 (0.36, 0.48) 0.41 (0.31, 0.46) 0.46 (0.36, 0.48) 0.43 (0.21, 0.49) NA (NA, NA) 0.36 (0.21, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.151 (0.099, 0.337) 0.151 (0.083, 0.421) 0.159 (0.097, 0.344) 0.158 (0.093, 0.282) 0.111 (0.033, 0.153) 0.2 (0.081, 0.703) 0.206 (0, 2.434) 0.199 (0, 1) 0.259 (0.094, 0.797) 0.262 (0.075, 0.812) 0.092 (0.092, 0.092) 0.159 (0.097, 0.375) 0 (0, 0) 2.207 (0.55, 3.864) NA (NA, NA) 0.174 (0, 0.307)
PI3K+ TC2 count 56 56 56 56 56 56 56 56 56 56 56 56 56 56 56 56
PI3K+ TC2 time 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33)
PI3K+ TC2 n 6 (2, 12) 3 (1, 6) 6 (3, 12) 5 (2, 10) 0 (0, 0) 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 2 (0, 3) 0 (0, 0) 5 (3, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.37 (0.19, 0.48) 0.38 (0.18, 0.49) 0.35 (0.14, 0.48) 0.36 (0.16, 0.47) NA (NA, NA) 0.44 (0.33, 0.5) 0.43 (0.34, 0.49) 0.44 (0.37, 0.49) 0.44 (0.37, 0.47) 0.42 (0.33, 0.48) NA (NA, NA) 0.34 (0.18, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.148 (0.099, 0.362) 0.173 (0.093, 0.397) 0.145 (0.093, 0.246) 0.14 (0.095, 0.372) NA (NA, NA) 0.18 (0.049, 0.936) 0.194 (0.019, 2.971) 0.172 (0, 5.649) 0.2 (0.069, 0.744) 0.192 (0.079, 0.549) 2.233 (2.233, 2.233) 0.144 (0.091, 0.275) 0.962 (0.267, 1.656) 0.234 (0.163, 0.304) 1.811 (0.575, 3.047) 0.139 (0.028, 0.251)
PI3K+ TC3 count 42 42 42 42 42 42 42 42 42 42 42 42 42 42 42 42
PI3K+ TC3 time 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33) 25 (18, 33)
PI3K+ TC3 n 5 (2, 14) 4 (1, 8) 6 (3, 17) 5 (2, 10) 0 (0, 0) 2 (0, 4) 1 (0, 3) 1 (0, 3) 0 (0, 2) 2 (0, 4) 0 (0, 0) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.35 (0.19, 0.49) 0.36 (0.17, 0.47) 0.36 (0.13, 0.45) 0.38 (0.24, 0.49) NA (NA, NA) 0.41 (0.3, 0.46) 0.45 (0.31, 0.48) 0.44 (0.34, 0.49) 0.45 (0.37, 0.48) 0.38 (0.3, 0.46) NA (NA, NA) 0.32 (0.19, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.148 (0.098, 0.283) 0.164 (0.098, 0.573) 0.153 (0.099, 0.301) 0.14 (0.098, 0.305) NA (NA, NA) 0.244 (0.112, 0.588) 0.175 (0.033, 0.694) 0.155 (0.07, 0.322) 0.323 (0.057, 0.701) 0.164 (0.079, 0.525) 0.127 (0.113, 0.321) 0.15 (0.105, 0.446) 0 (0, 0.071) NA (NA, NA) NA (NA, NA) 0.058 (0.058, 0.058)
PI3K+ TC4 count 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50
PI3K+ TC4 time 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33)
PI3K+ TC4 n 5 (3, 14) 3 (1, 7) 6 (3, 10) 4 (2, 8) 0 (0, 0) 2 (0, 5) 1 (0, 3) 1 (0, 3) 0 (0, 3) 1 (0, 4) 0 (0, 0) 3 (1, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.32 (0.19, 0.48) 0.39 (0.23, 0.48) 0.35 (0.18, 0.48) 0.35 (0.17, 0.47) NA (NA, NA) 0.41 (0.24, 0.49) 0.42 (0.31, 0.49) 0.42 (0.35, 0.48) 0.43 (0.27, 0.49) 0.44 (0.28, 0.48) NA (NA, NA) 0.36 (0.16, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.152 (0.095, 0.291) 0.169 (0.105, 0.344) 0.134 (0.095, 0.222) 0.149 (0.098, 0.381) 0.058 (0.012, 0.149) 0.141 (0.067, 0.611) 0.262 (0.099, 0.984) 0.214 (0.062, 0.978) 0.16 (0, 0.767) 0.161 (0.086, 0.494) 1.048 (1.048, 1.048) 0.193 (0.101, 0.589) NA (NA, NA) 0.188 (0.148, 0.228) 0.168 (0.034, 0.303) 0.246 (0.212, 1.188)